Multicellular regulation of insulin secretion from pancreatic islets

Publikacje

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

Autorzy: Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen
Opublikowane w: Organic & Biomolecular Chemistry, Numer 13, 2022, ISSN 1477-0520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1ob02216d

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Autorzy: Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J Hodson, Erin E Mulvihill, Sophie Petropoulos, Gareth E Lim
Opublikowane w: JCI Insight, Numer 7(8), 2022, Strona(/y) e156378, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.156378

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

Autorzy: Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP
Opublikowane w: PLoS Biology, Numer 20(9), 2022, Strona(/y) e3001761, ISSN 1544-9173
Wydawca: Public Library of Science
DOI: 10.1371/journal.pbio.3001761

GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress

Autorzy: Katrina Viloria; Daniela Nasteska; Julia Ast; Annie Hasib; Federica Cuozzo; Silke Heising; Linford J.B. Briant; Martin Hewison; David J. Hodson
Opublikowane w: Diabetes, Numer db220326, 2022, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/db22-0326

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Autorzy: Julia Ast; Alissa N. Novak; Tom Podewin; Nicholas H. F. Fine; Ben Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia K. Linnemann; David J. Hodson; Johannes Broichhagen
Opublikowane w: JACS Au, Numer 6, 2022, ISSN 2691-3704
Wydawca: ACS
DOI: 10.1021/jacsau.2c00130

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.

Autorzy: Katrina Viloria; Katrina Viloria; Daniela Nasteska; Daniela Nasteska; Linford J.B. Briant; Silke Heising; Silke Heising; Dean Larner; Dean Larner; Nicholas H. F. Fine; Nicholas H. F. Fine; Fiona B. Ashford; Fiona B. Ashford; Gabriela da Silva Xavier; Gabriela da Silva Xavier; Maria Jiménez Ramos; Maria Jiménez Ramos; Annie Hasib; Annie Hasib; Federica Cuozzo; Federica Cuozzo; Jocelyn E. Manning
Opublikowane w: Cell Reports, Numer 11, 2020, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107761

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Autorzy: Daniela Nasteska; Daniela Nasteska; Federica Cuozzo; Federica Cuozzo; Alpesh Thakker; Alpesh Thakker; Rula Bany Bakar; Rebecca L. Westbrook; Rebecca L. Westbrook; Ildem Akerman; Ildem Akerman; James Cantley; James Cantley; Daniel A. Tennant; Daniel A. Tennant; David J. Hodson; David J. Hodson
Opublikowane w: JCI Insight, Numer 17, 2021, ISSN 2379-3708
Wydawca: ASCI
DOI: 10.1101/2020.04.30.068106

Glucagon-like peptide-1 receptor regulates thromboxane-induced human platelet activation

Autorzy: Katherine N. Cahill; Taneem Amin; Olivier Boutaud; Richard Printz; Dawn C. Newcomb; Dinah Foer; David J. Hodson; Johannes Broichhagen; Joshua A. Beckman; Chang Yu; Hui Nian; Mona Mashayekhi; Heidi J. Silver; James M. Luther; Nancy J. Brown; R. Stokes Peebles; Kevin Niswender
Opublikowane w: JACC Basic to translational science, Numer 3, 2022, ISSN 2452-302X
Wydawca: JACC
DOI: 10.1016/j.jacbts.2022.04.004

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

Autorzy: Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder
Opublikowane w: Chemical Science, Numer 8/6, 2017, Strona(/y) 4644-4653, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c6sc05044a

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Autorzy: Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen
Opublikowane w: ChemistryOpen, Numer 6/4, 2017, Strona(/y) 501-505, ISSN 2191-1363
Wydawca: Wiley
DOI: 10.1002/open.201700062

The role of beta cell heterogeneity in islet function and insulin release

Autorzy: Daniela Nasteska, David J Hodson
Opublikowane w: Journal of Molecular Endocrinology, Numer 61/1, 2018, Strona(/y) R43-R60, ISSN 0952-5041
Wydawca: Society for Endocrinology
DOI: 10.1530/JME-18-0011

Remote control of glucose homeostasis in vivo using photopharmacology

Autorzy: Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-00397-0

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling

Autorzy: Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom
Opublikowane w: Endocrinology, Numer 158/8, 2017, Strona(/y) 2680-2693, ISSN 0013-7227
Wydawca: The Endocrine Society
DOI: 10.1210/en.2016-1755

Autorzy: Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/eLife.32965

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice

Autorzy: Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter
Opublikowane w: Journal of Biological Chemistry, Numer 292/21, 2017, Strona(/y) 8892-8906, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M117.784629

Optical control of GPR40 signalling in pancreatic β-cells

Autorzy: James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner
Opublikowane w: Chem. Sci., Numer 8/11, 2017, Strona(/y) 7604-7610, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c7sc01475a

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Autorzy: Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Opublikowane w: Cell Reports, Numer 22/12, 2018, Strona(/y) 3107-3114, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2018.02.084

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Autorzy: Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Opublikowane w: ACS Central Science, Numer 4/2, 2018, Strona(/y) 166-179, ISSN 2374-7943
Wydawca: American Chemical Society
DOI: 10.1021/acscentsci.7b00237

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Autorzy: Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Opublikowane w: JCI Insight, Numer 3/12, 2018, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.98607

Optical tools for understanding the complexity of β-cell signalling and insulin release

Autorzy: James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson
Opublikowane w: Nature Reviews Endocrinology, Numer 14/12, 2018, Strona(/y) 721-737, ISSN 1759-5029
Wydawca: Nature Publishing Group
DOI: 10.1038/s41574-018-0105-2

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

Autorzy: Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter
Opublikowane w: Current Diabetes Reports, Numer 18/11, 2018, ISSN 1534-4827
Wydawca: Current Science Inc.
DOI: 10.1007/s11892-018-1085-2

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Autorzy: Richard K.P. Benninger, David J. Hodson
Opublikowane w: Diabetes, Numer 67/4, 2018, Strona(/y) 537-547, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/dbi17-0040

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

Autorzy: Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton
Opublikowane w: Diabetologia, 2019, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-019-05029-y

Informing β-cell regeneration strategies using studies of heterogeneity

Autorzy: Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson
Opublikowane w: Molecular Metabolism, Numer 27, 2019, Strona(/y) S49-S59, ISSN 2212-8778
Wydawca: Elsevier GmbH
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Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Autorzy: Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn
Opublikowane w: Cell Reports, Numer 26/7, 2019, Strona(/y) 1787-1799.e5, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.01.067

Dimerization of the Sodium/Iodide Symporter

Autorzy: Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe
Opublikowane w: Thyroid, Numer 29/10, 2019, Strona(/y) 1485-1498, ISSN 1050-7256
Wydawca: Mary Ann Liebert Inc.
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A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Autorzy: Michael W. O'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair
Opublikowane w: JCI Insight, 2019, ISSN 2379-3708
Wydawca: JCI
DOI: 10.1172/jci.insight.125348

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Autorzy: Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Po
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-14309-w

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

Autorzy: Yasmine Kemkem, Daniela Nasteska, Anne de Bray, Paula Bargi-Souza, Rodrigo A. Peliciari-Garcia, Anne Guillou, Patrice Mollard, David J. Hodson, Marie Schaeffer
Opublikowane w: Diabetologia, 2020, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-020-05172-x

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Autorzy: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alp
Opublikowane w: Molecular Metabolism, 2020, Strona(/y) 101015, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101015

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

Autorzy: Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Opublikowane w: British Journal of Pharmacology, 2020, ISSN 0007-1188
Wydawca: Wiley-Blackwell
DOI: 10.1111/bph.15134

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Autorzy: Zijian Fang, Shiqian Chen, Philip Pickford, Johannes Broichhagen, David J. Hodson, Ivan R. Corrêa, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M. W. French, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Opublikowane w: ACS Pharmacology & Translational Science, Numer 3/2, 2020, Strona(/y) 345-360, ISSN 2575-9108
Wydawca: ACS
DOI: 10.1021/acsptsci.0c00022

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

Autorzy: David J. Hodson, Patrik Rorsman
Opublikowane w: Diabetes, Numer 69/5, 2020, Strona(/y) 864-866, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/dbi19-0035

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

Autorzy: Alex P. Seabright, Nicholas H. F. Fine, Jonathan P. Barlow, Samuel O. Lord, Ibrahim Musa, Alexander Gray, Jack A. Bryant, Manuel Banzhaf, Gareth G. Lavery, D. Grahame Hardie, David J. Hodson, Andrew Philp, Yu‐Chiang Lai
Opublikowane w: The FASEB Journal, Numer 34/5, 2020, Strona(/y) 6284-6301, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
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Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

Autorzy: Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen
Opublikowane w: Chemical Science, Numer 22, 2021, ISSN 2041-6539
Wydawca: RSC
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PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autorzy: Daniela Nasteska , Nicholas H F Fine, Fiona B Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W J Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J Hodson
Opublikowane w: Nature Communications, Numer 12(1), 2021, Strona(/y) 674, ISSN 2041-1723
Wydawca: Nature Publishing Group
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GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

Autorzy: Audrys G Pauza, Pratik Thakkar, Tatjana Tasic, Igor Felippe, Paul Bishop, Michael P Greenwood, Kristina Rysevaite-Kyguoliene, Julia Ast, Johannes Broichhagen, David J Hodson, Helio C Salgado, Dainius H Pauza, Nina Japundzic-Zigon, Julian F R Paton, David Murphy
Opublikowane w: Circulation Research, Numer 130(5), 2022, Strona(/y) 694-707, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319874

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