Publications Peer reviewed articles (37) Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins Auteurs: Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen Publié dans: Organic & Biomolecular Chemistry, Numéro 13, 2022, ISSN 1477-0520 Éditeur: Royal Society of Chemistry DOI: 10.1039/d1ob02216d 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells Auteurs: Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J Hodson, Erin E Mulvihill, Sophie Petropoulos, Gareth E Lim Publié dans: JCI Insight, Numéro 7(8), 2022, Page(s) e156378, ISSN 0021-9738 Éditeur: American Society for Clinical Investigation DOI: 10.1172/jci.insight.156378 Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response Auteurs: Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP Publié dans: PLoS Biology, Numéro 20(9), 2022, Page(s) e3001761, ISSN 1544-9173 Éditeur: Public Library of Science DOI: 10.1371/journal.pbio.3001761 GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress Auteurs: Katrina Viloria; Daniela Nasteska; Julia Ast; Annie Hasib; Federica Cuozzo; Silke Heising; Linford J.B. Briant; Martin Hewison; David J. Hodson Publié dans: Diabetes, Numéro db220326, 2022, ISSN 0012-1797 Éditeur: American Diabetes Association DOI: 10.2337/db22-0326 An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo Auteurs: Julia Ast; Alissa N. Novak; Tom Podewin; Nicholas H. F. Fine; Ben Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia K. Linnemann; David J. Hodson; Johannes Broichhagen Publié dans: JACS Au, Numéro 6, 2022, ISSN 2691-3704 Éditeur: ACS DOI: 10.1021/jacsau.2c00130 Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Auteurs: Katrina Viloria; Katrina Viloria; Daniela Nasteska; Daniela Nasteska; Linford J.B. Briant; Silke Heising; Silke Heising; Dean Larner; Dean Larner; Nicholas H. F. Fine; Nicholas H. F. Fine; Fiona B. Ashford; Fiona B. Ashford; Gabriela da Silva Xavier; Gabriela da Silva Xavier; Maria Jiménez Ramos; Maria Jiménez Ramos; Annie Hasib; Annie Hasib; Federica Cuozzo; Federica Cuozzo; Jocelyn E. Manning Publié dans: Cell Reports, Numéro 11, 2020, ISSN 2211-1247 Éditeur: Cell Press DOI: 10.1016/j.celrep.2020.107761 The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess Auteurs: Daniela Nasteska; Daniela Nasteska; Federica Cuozzo; Federica Cuozzo; Alpesh Thakker; Alpesh Thakker; Rula Bany Bakar; Rebecca L. Westbrook; Rebecca L. Westbrook; Ildem Akerman; Ildem Akerman; James Cantley; James Cantley; Daniel A. Tennant; Daniel A. Tennant; David J. Hodson; David J. Hodson Publié dans: JCI Insight, Numéro 17, 2021, ISSN 2379-3708 Éditeur: ASCI DOI: 10.1101/2020.04.30.068106 Glucagon-like peptide-1 receptor regulates thromboxane-induced human platelet activation Auteurs: Katherine N. Cahill; Taneem Amin; Olivier Boutaud; Richard Printz; Dawn C. Newcomb; Dinah Foer; David J. Hodson; Johannes Broichhagen; Joshua A. Beckman; Chang Yu; Hui Nian; Mona Mashayekhi; Heidi J. Silver; James M. Luther; Nancy J. Brown; R. Stokes Peebles; Kevin Niswender Publié dans: JACC Basic to translational science, Numéro 3, 2022, ISSN 2452-302X Éditeur: JACC DOI: 10.1016/j.jacbts.2022.04.004 Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone Auteurs: Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder Publié dans: Chemical Science, Numéro 8/6, 2017, Page(s) 4644-4653, ISSN 2041-6520 Éditeur: Royal Society of Chemistry DOI: 10.1039/c6sc05044a Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor Auteurs: Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen Publié dans: ChemistryOpen, Numéro 6/4, 2017, Page(s) 501-505, ISSN 2191-1363 Éditeur: Wiley DOI: 10.1002/open.201700062 The role of beta cell heterogeneity in islet function and insulin release Auteurs: Daniela Nasteska, David J Hodson Publié dans: Journal of Molecular Endocrinology, Numéro 61/1, 2018, Page(s) R43-R60, ISSN 0952-5041 Éditeur: Society for Endocrinology DOI: 10.1530/JME-18-0011 Remote control of glucose homeostasis in vivo using photopharmacology Auteurs: Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-017-00397-0 RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling Auteurs: Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom Publié dans: Endocrinology, Numéro 158/8, 2017, Page(s) 2680-2693, ISSN 0013-7227 Éditeur: The Endocrine Society DOI: 10.1210/en.2016-1755 Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Auteurs: Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov Publié dans: eLife, Numéro 7, 2018, ISSN 2050-084X Éditeur: eLife Sciences Publications DOI: 10.7554/eLife.32965 The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice Auteurs: Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter Publié dans: Journal of Biological Chemistry, Numéro 292/21, 2017, Page(s) 8892-8906, ISSN 0021-9258 Éditeur: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M117.784629 Optical control of GPR40 signalling in pancreatic β-cells Auteurs: James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner Publié dans: Chem. Sci., Numéro 8/11, 2017, Page(s) 7604-7610, ISSN 2041-6520 Éditeur: Royal Society of Chemistry DOI: 10.1039/c7sc01475a Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis Auteurs: Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant Publié dans: Cell Reports, Numéro 22/12, 2018, Page(s) 3107-3114, ISSN 2211-1247 Éditeur: Cell Press DOI: 10.1016/j.celrep.2018.02.084 Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology Auteurs: Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson Publié dans: ACS Central Science, Numéro 4/2, 2018, Page(s) 166-179, ISSN 2374-7943 Éditeur: American Chemical Society DOI: 10.1021/acscentsci.7b00237 Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes Auteurs: Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis Publié dans: JCI Insight, Numéro 3/12, 2018, ISSN 2379-3708 Éditeur: American Society for Clinical Investigation DOI: 10.1172/jci.insight.98607 Optical tools for understanding the complexity of β-cell signalling and insulin release Auteurs: James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson Publié dans: Nature Reviews Endocrinology, Numéro 14/12, 2018, Page(s) 721-737, ISSN 1759-5029 Éditeur: Nature Publishing Group DOI: 10.1038/s41574-018-0105-2 The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis Auteurs: Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter Publié dans: Current Diabetes Reports, Numéro 18/11, 2018, ISSN 1534-4827 Éditeur: Current Science Inc. DOI: 10.1007/s11892-018-1085-2 New Understanding of β-Cell Heterogeneity and In Situ Islet Function Auteurs: Richard K.P. Benninger, David J. Hodson Publié dans: Diabetes, Numéro 67/4, 2018, Page(s) 537-547, ISSN 0012-1797 Éditeur: American Diabetes Association DOI: 10.2337/dbi17-0040 Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes Auteurs: Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton Publié dans: Diabetologia, 2019, ISSN 0012-186X Éditeur: Springer Verlag DOI: 10.1007/s00125-019-05029-y Informing β-cell regeneration strategies using studies of heterogeneity Auteurs: Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson Publié dans: Molecular Metabolism, Numéro 27, 2019, Page(s) S49-S59, ISSN 2212-8778 Éditeur: Elsevier GmbH DOI: 10.1016/j.molmet.2019.06.004 Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons Auteurs: Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn Publié dans: Cell Reports, Numéro 26/7, 2019, Page(s) 1787-1799.e5, ISSN 2211-1247 Éditeur: Cell Press DOI: 10.1016/j.celrep.2019.01.067 Dimerization of the Sodium/Iodide Symporter Auteurs: Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe Publié dans: Thyroid, Numéro 29/10, 2019, Page(s) 1485-1498, ISSN 1050-7256 Éditeur: Mary Ann Liebert Inc. DOI: 10.1089/thy.2019.0034 A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics Auteurs: Michael W. O'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair Publié dans: JCI Insight, 2019, ISSN 2379-3708 Éditeur: JCI DOI: 10.1172/jci.insight.125348 Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics Auteurs: Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Po Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-020-14309-w Maternal hypothyroidism in mice influences glucose metabolism in adult offspring Auteurs: Yasmine Kemkem, Daniela Nasteska, Anne de Bray, Paula Bargi-Souza, Rodrigo A. Peliciari-Garcia, Anne Guillou, Patrice Mollard, David J. Hodson, Marie Schaeffer Publié dans: Diabetologia, 2020, ISSN 0012-186X Éditeur: Springer Verlag DOI: 10.1007/s00125-020-05172-x The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis Auteurs: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alp Publié dans: Molecular Metabolism, 2020, Page(s) 101015, ISSN 2212-8778 Éditeur: Elsevier GmbH DOI: 10.1016/j.molmet.2020.101015 Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide Auteurs: Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones Publié dans: British Journal of Pharmacology, 2020, ISSN 0007-1188 Éditeur: Wiley-Blackwell DOI: 10.1111/bph.15134 The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists Auteurs: Zijian Fang, Shiqian Chen, Philip Pickford, Johannes Broichhagen, David J. Hodson, Ivan R. Corrêa, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M. W. French, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones Publié dans: ACS Pharmacology & Translational Science, Numéro 3/2, 2020, Page(s) 345-360, ISSN 2575-9108 Éditeur: ACS DOI: 10.1021/acsptsci.0c00022 A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets Auteurs: David J. Hodson, Patrik Rorsman Publié dans: Diabetes, Numéro 69/5, 2020, Page(s) 864-866, ISSN 0012-1797 Éditeur: American Diabetes Association DOI: 10.2337/dbi19-0035 AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner Auteurs: Alex P. Seabright, Nicholas H. F. Fine, Jonathan P. Barlow, Samuel O. Lord, Ibrahim Musa, Alexander Gray, Jack A. Bryant, Manuel Banzhaf, Gareth G. Lavery, D. Grahame Hardie, David J. Hodson, Andrew Philp, Yu‐Chiang Lai Publié dans: The FASEB Journal, Numéro 34/5, 2020, Page(s) 6284-6301, ISSN 0892-6638 Éditeur: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.201903051r Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates Auteurs: Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen Publié dans: Chemical Science, Numéro 22, 2021, ISSN 2041-6539 Éditeur: RSC DOI: 10.1101/2020.01.29.924829 PDX1LOW MAFALOW β-cells contribute to islet function and insulin release Auteurs: Daniela Nasteska , Nicholas H F Fine, Fiona B Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W J Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J Hodson Publié dans: Nature Communications, Numéro 12(1), 2021, Page(s) 674, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-020-20632-z GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition Auteurs: Audrys G Pauza, Pratik Thakkar, Tatjana Tasic, Igor Felippe, Paul Bishop, Michael P Greenwood, Kristina Rysevaite-Kyguoliene, Julia Ast, Johannes Broichhagen, David J Hodson, Helio C Salgado, Dainius H Pauza, Nina Japundzic-Zigon, Julian F R Paton, David Murphy Publié dans: Circulation Research, Numéro 130(5), 2022, Page(s) 694-707, ISSN 0009-7330 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.121.319874 Recherche de données OpenAIRE... Une erreur s’est produite lors de la recherche de données OpenAIRE Aucun résultat disponible
