Multicellular regulation of insulin secretion from pancreatic islets

Informazioni relative al progetto

OptoBETA

ID dell’accordo di sovvenzione: 715884

DOI

10.3030/715884

Progetto chiuso

Data della firma CE 25 Novembre 2016

Data di avvio 1 Giugno 2017

Data di completamento 30 Novembre 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 681 468,00

Contributo UE

€ 1 681 468,00

Coordinato da

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (37)

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

Autori: Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen
Pubblicato in: Organic & Biomolecular Chemistry, Numero 13, 2022, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1ob02216d

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Autori: Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J Hodson, Erin E Mulvihill, Sophie Petropoulos, Gareth E Lim
Pubblicato in: JCI Insight, Numero 7(8), 2022, Pagina/e e156378, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.156378

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

Autori: Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP
Pubblicato in: PLoS Biology, Numero 20(9), 2022, Pagina/e e3001761, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001761

GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress

Autori: Katrina Viloria; Daniela Nasteska; Julia Ast; Annie Hasib; Federica Cuozzo; Silke Heising; Linford J.B. Briant; Martin Hewison; David J. Hodson
Pubblicato in: Diabetes, Numero db220326, 2022, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db22-0326

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Autori: Julia Ast; Alissa N. Novak; Tom Podewin; Nicholas H. F. Fine; Ben Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia K. Linnemann; David J. Hodson; Johannes Broichhagen
Pubblicato in: JACS Au, Numero 6, 2022, ISSN 2691-3704
Editore: ACS
DOI: 10.1021/jacsau.2c00130

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.

Autori: Katrina Viloria; Katrina Viloria; Daniela Nasteska; Daniela Nasteska; Linford J.B. Briant; Silke Heising; Silke Heising; Dean Larner; Dean Larner; Nicholas H. F. Fine; Nicholas H. F. Fine; Fiona B. Ashford; Fiona B. Ashford; Gabriela da Silva Xavier; Gabriela da Silva Xavier; Maria Jiménez Ramos; Maria Jiménez Ramos; Annie Hasib; Annie Hasib; Federica Cuozzo; Federica Cuozzo; Jocelyn E. Manning
Pubblicato in: Cell Reports, Numero 11, 2020, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107761

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Autori: Daniela Nasteska; Daniela Nasteska; Federica Cuozzo; Federica Cuozzo; Alpesh Thakker; Alpesh Thakker; Rula Bany Bakar; Rebecca L. Westbrook; Rebecca L. Westbrook; Ildem Akerman; Ildem Akerman; James Cantley; James Cantley; Daniel A. Tennant; Daniel A. Tennant; David J. Hodson; David J. Hodson
Pubblicato in: JCI Insight, Numero 17, 2021, ISSN 2379-3708
Editore: ASCI
DOI: 10.1101/2020.04.30.068106

Glucagon-like peptide-1 receptor regulates thromboxane-induced human platelet activation

Autori: Katherine N. Cahill; Taneem Amin; Olivier Boutaud; Richard Printz; Dawn C. Newcomb; Dinah Foer; David J. Hodson; Johannes Broichhagen; Joshua A. Beckman; Chang Yu; Hui Nian; Mona Mashayekhi; Heidi J. Silver; James M. Luther; Nancy J. Brown; R. Stokes Peebles; Kevin Niswender
Pubblicato in: JACC Basic to translational science, Numero 3, 2022, ISSN 2452-302X
Editore: JACC
DOI: 10.1016/j.jacbts.2022.04.004

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

Autori: Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder
Pubblicato in: Chemical Science, Numero 8/6, 2017, Pagina/e 4644-4653, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c6sc05044a

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Autori: Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen
Pubblicato in: ChemistryOpen, Numero 6/4, 2017, Pagina/e 501-505, ISSN 2191-1363
Editore: Wiley
DOI: 10.1002/open.201700062

The role of beta cell heterogeneity in islet function and insulin release

Autori: Daniela Nasteska, David J Hodson
Pubblicato in: Journal of Molecular Endocrinology, Numero 61/1, 2018, Pagina/e R43-R60, ISSN 0952-5041
Editore: Society for Endocrinology
DOI: 10.1530/JME-18-0011

Remote control of glucose homeostasis in vivo using photopharmacology

Autori: Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-00397-0

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling

Autori: Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom
Pubblicato in: Endocrinology, Numero 158/8, 2017, Pagina/e 2680-2693, ISSN 0013-7227
Editore: The Endocrine Society
DOI: 10.1210/en.2016-1755

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

Autori: Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.32965

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice

Autori: Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter
Pubblicato in: Journal of Biological Chemistry, Numero 292/21, 2017, Pagina/e 8892-8906, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M117.784629

Optical control of GPR40 signalling in pancreatic β-cells

Autori: James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner
Pubblicato in: Chem. Sci., Numero 8/11, 2017, Pagina/e 7604-7610, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c7sc01475a

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Autori: Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Pubblicato in: Cell Reports, Numero 22/12, 2018, Pagina/e 3107-3114, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.02.084

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Autori: Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Pubblicato in: ACS Central Science, Numero 4/2, 2018, Pagina/e 166-179, ISSN 2374-7943
Editore: American Chemical Society
DOI: 10.1021/acscentsci.7b00237

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Autori: Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Pubblicato in: JCI Insight, Numero 3/12, 2018, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.98607

Optical tools for understanding the complexity of β-cell signalling and insulin release

Autori: James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson
Pubblicato in: Nature Reviews Endocrinology, Numero 14/12, 2018, Pagina/e 721-737, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-018-0105-2

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

Autori: Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter
Pubblicato in: Current Diabetes Reports, Numero 18/11, 2018, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-018-1085-2

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Autori: Richard K.P. Benninger, David J. Hodson
Pubblicato in: Diabetes, Numero 67/4, 2018, Pagina/e 537-547, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi17-0040

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

Autori: Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton
Pubblicato in: Diabetologia, 2019, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-05029-y

Informing β-cell regeneration strategies using studies of heterogeneity

Autori: Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson
Pubblicato in: Molecular Metabolism, Numero 27, 2019, Pagina/e S49-S59, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.004

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Autori: Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn
Pubblicato in: Cell Reports, Numero 26/7, 2019, Pagina/e 1787-1799.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.01.067

Dimerization of the Sodium/Iodide Symporter

Autori: Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe
Pubblicato in: Thyroid, Numero 29/10, 2019, Pagina/e 1485-1498, ISSN 1050-7256
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/thy.2019.0034

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Autori: Michael W. O'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair
Pubblicato in: JCI Insight, 2019, ISSN 2379-3708
Editore: JCI
DOI: 10.1172/jci.insight.125348

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Autori: Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Po
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14309-w

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

Autori: Yasmine Kemkem, Daniela Nasteska, Anne de Bray, Paula Bargi-Souza, Rodrigo A. Peliciari-Garcia, Anne Guillou, Patrice Mollard, David J. Hodson, Marie Schaeffer
Pubblicato in: Diabetologia, 2020, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05172-x

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Autori: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alp
Pubblicato in: Molecular Metabolism, 2020, Pagina/e 101015, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101015

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

Autori: Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Pubblicato in: British Journal of Pharmacology, 2020, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.15134

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Autori: Zijian Fang, Shiqian Chen, Philip Pickford, Johannes Broichhagen, David J. Hodson, Ivan R. Corrêa, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M. W. French, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Pubblicato in: ACS Pharmacology & Translational Science, Numero 3/2, 2020, Pagina/e 345-360, ISSN 2575-9108
Editore: ACS
DOI: 10.1021/acsptsci.0c00022

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

Autori: David J. Hodson, Patrik Rorsman
Pubblicato in: Diabetes, Numero 69/5, 2020, Pagina/e 864-866, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi19-0035

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

Autori: Alex P. Seabright, Nicholas H. F. Fine, Jonathan P. Barlow, Samuel O. Lord, Ibrahim Musa, Alexander Gray, Jack A. Bryant, Manuel Banzhaf, Gareth G. Lavery, D. Grahame Hardie, David J. Hodson, Andrew Philp, Yu‐Chiang Lai
Pubblicato in: The FASEB Journal, Numero 34/5, 2020, Pagina/e 6284-6301, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201903051r

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

Autori: Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen
Pubblicato in: Chemical Science, Numero 22, 2021, ISSN 2041-6539
Editore: RSC
DOI: 10.1101/2020.01.29.924829

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autori: Daniela Nasteska , Nicholas H F Fine, Fiona B Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W J Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J Hodson
Pubblicato in: Nature Communications, Numero 12(1), 2021, Pagina/e 674, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20632-z

GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

Autori: Audrys G Pauza, Pratik Thakkar, Tatjana Tasic, Igor Felippe, Paul Bishop, Michael P Greenwood, Kristina Rysevaite-Kyguoliene, Julia Ast, Johannes Broichhagen, David J Hodson, Helio C Salgado, Dainius H Pauza, Nina Japundzic-Zigon, Julian F R Paton, David Murphy
Pubblicato in: Circulation Research, Numero 130(5), 2022, Pagina/e 694-707, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319874