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Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes

Risultati finali

Mid term plan for using and disseminating the Know-how for the nest period

Mid term Plan for using and disseminating the Know-how for the next period

Final report on the LCC and LCA of the final processes and products

Final report on the LCC and LCA of the final processes and products

Final Report and demonstration of real time monitoring by the PBI of the NPs size, concentration and coating uniformity of the end product

Final Report and demonstration of real time monitoring by the PBI of the NPs size, concentration and coating uniformity of the end product

Information sheets for workers and users of the final products, explaining nano-specific properties and procedures

Information sheets for workers and users of the final products, explaining nano-specific properties and procedures

First Report on Safety by Process Design implementation for the coating processes

Report on Safety by Process Design implementation for the coating processes. All coating processes will by designed by Safety by design

Report and demonstration of the automation system for solution delivery and adjustment of pH, concentration and fabric speed of the three processes

Report and demonstration of the automation system for solution delivery and adjustment of pH, concentration and fabric speed of the three processes

Staff exchange plan between SMEs and R&D centres

Staff exchange plan between SMEs and R&D centres

Report on the most efficient and sustainable processes and active agents for each end product and application

Report on the most efficient and sustainable processes and active agents for each end product

Report on human nano-toxicology of the functional products according to the NanoSafety Cluster and OECD guidelines

Report on human nano-toxicology of the functional products according to the NanoSafety Cluster and OECD guidelines

Report on the hazard determinants for the environment safety profile of the new processes and end products

Report on the hazard determinants for the environment safety profile of the new processes and end products

Final Report on the anti-biofilm efficiency of the water treatment membranes used in water scarce area - Catania and Gela, in Sicily

Final Report on the anti-biofilm efficiency of the water treatment membranes used in water scarce area - Catania and Gela, in Sicily

Report on the smart metabolic sensing for functional life time monitoring of the end products

Report on the smart metabolic sensing for functional life time monitoring of the end products

Report on the establishment of the PROTECT PLN including a brochure to detail technologies, services and prices

Report on the establishment of the PROTECT PLN including a brochure to detail technologies services and prices

Fianal Report on Safety by Process Design implementation for the three coating processes

All coating processes will be designed implementing Safety by design

Report on the three training sessions for consortium SMEs during the project

Report on the three training sessions for consortium SMEs during the project

Report on the assembled pre-commercial coating lines at the industrial premises of the partners

Report on the assembled pre-commercial coating lines at the industrial premises of the partners

Report on HSE Risk Management

Report on HSE Risk Management

Report on training courses for employees about the use of the control and monitoring systems

Report on training courses for employee about the use of the control and monitoring systems

Summary of the assessment of standards and regulatory issues

Summary of the assessment of standards and regulatory issues

Report on recommendations for the full scale lines based on the LCC and LCA studies

Report on recommendations for the full scale lines based on the LCC and LCA studies

First report and demonstration of real time monitoring by the PBI of the NPs size, concentration and coating uniformity of the end product

Report and demonstration of real time monitoring by the PBI of the NPs size, concentration and coating uniformity of the end product

Report on the LCC and LCA of the three coating processes and recommendation for improvements based on inputs from the existing pilots

Report on the LCC and LCA of the three coating processes and recommendation for improvements based on inputs from the existing pilots

Report on the LCC and LCA of the processes and products and recommendations for improvement after the first operation of the pilots and analyses of the products

Report on the LCC and LCA of the processes and products and recommendations for improvement after the first operation of the pilots and products analyses

Report on the characteristics of the functional products from the pre-commercial lines (antibacterial/anti-biofilm activity, biocompatibility, abrasion resistance, mechanical parameters; for membranes: also filtration efficiency as a function of time)

Report on the characteristics of the functional products from the pre-commercial lines (antibacterial/anti-biofilm activity, biocompatibility, abrasion resistance, mechanical parameters; for membranes: also filtration efficiency as a function of time)

Report on the up-scaled pre-commercial processes, including the monitoring and automation system

Report on the up-scaled pre-commercial processes, including the monitoring and automation system

Report on two workshops with the European nanosafety cluster partners

Report on two workshops with the European nanosafety cluster partners

Plan for using and disseminating the Know-how

Plan for using and disseminating the Know-how

Report on the anti-biofilm efficiency of the water treatment membranes used in water scarce area - Catania and Gela, in Sicily

Report on the anti-biofilm efficiency of the water treatment membranes used in water scarce area - Catania and Gela, in Sicily

Report on the potential occurrence of bacterial resistance to the proposed antibacterial products and application

Report on the potential occurrence of bacterial resistance to the proposed antibacterial products

Report on market analysis and economic impact of the new products

Report on market analysis and economic impact of the new products

Final Report on the metabolic sensing for functional life time monitoring of the end products

Final Report on the smart metabolic sensing for functional life time monitoring of the end products

Public Project website

Public Project website

Project brochure addressing the pre-commercial lines and associated products

Project brochure addressing the pre-commercial lines and associated products

Publication of at least 5 scientific articles in international scientific journals

Publication of at least 5 scientific articles in international scientific journals

Participation in at least 5 international conferences

Participation in at least 5 conferences

Pubblicazioni

Antibody-Enabled Antimicrobial Nanocapsules for Selective Elimination of Staphylococcus aureus

Autori: Kristina Ivanova, Aleksandra Ivanova, Eva Ramon, Javier Hoyo, Susana Sanchez-Gomez, Tzanko Tzanov
Pubblicato in: ACS Applied Materials & Interfaces, Issue 12/32, 2020, Page(s) 35918-35927, ISSN 1944-8244
DOI: 10.1021/acsami.0c09364

Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials

Autori: Arnau Bassegoda, Kristina Ivanova, Eva Ramon, Tzanko Tzanov
Pubblicato in: Applied Microbiology and Biotechnology, Issue 102/5, 2018, Page(s) 2075-2089, ISSN 0175-7598
DOI: 10.1007/s00253-018-8776-0

The Toxic Truth About Carbon Nanotubes in Water Purification: a Perspective View

Autori: Rasel Das, Bey Fen Leo, Finbarr Murphy
Pubblicato in: Nanoscale Research Letters, Issue 13/1, 2018, ISSN 1931-7573
DOI: 10.1186/s11671-018-2589-z

Insuring nanotech requires effective risk communication

Autori: Finbarr Murphy, Martin Mullins, Karena Hester, Allen Gelwick, Janeck J. Scott-Fordsmand, Trevor Maynard
Pubblicato in: Nature Nanotechnology, Issue 12/8, 2017, Page(s) 717-719, ISSN 1748-3387
DOI: 10.1038/nnano.2017.162

Durable antimicrobial cotton textiles coated sonochemically with ZnO nanoparticles embedded in an in-situ enzymatically generated bioadhesive

Autori: Marc Salat, Petya Petkova, Javier Hoyo, Ilana Perelshtein, Aharon Gedanken, Tzanko Tzanov
Pubblicato in: Carbohydrate Polymers, Issue 189, 2018, Page(s) 198-203, ISSN 0144-8617
DOI: 10.1016/j.carbpol.2018.02.033

Innovative Approaches for Controlling Clinically Relevant Biofilms: Current Trends and Future Prospects

Autori: Kristina Ivanova, Eva Ramon, Javier Hoyo, Tzanko Tzanov
Pubblicato in: Current Topics in Medicinal Chemistry, Issue 17/17, 2017, Page(s) 1889-1914, ISSN 1568-0266
DOI: 10.2174/1568026617666170105143315

Hazard Screening Methods for Nanomaterials: A Comparative Study

Autori: Barry Sheehan, Finbarr Murphy, Martin Mullins, Irini Furxhi, Anna Costa, Felice Simeone, Paride Mantecca
Pubblicato in: International Journal of Molecular Sciences, Issue 19/3, 2018, Page(s) 649, ISSN 1422-0067
DOI: 10.3390/ijms19030649

Sonochemical synthesis and stabilization of concentrated antimicrobial silver-chitosan nanoparticle dispersions

Autori: Antonio Francesko, Marta Cano Fossas, Petya Petkova, Margarida M. Fernandes, Ernest Mendoza, Tzanko Tzanov
Pubblicato in: Journal of Applied Polymer Science, Issue 134/30, 2017, Page(s) 45136, ISSN 0021-8995
DOI: 10.1002/app.45136

Hybrid Chitosan–Silver Nanoparticles Enzymatically Embedded on Cork Filter Material for Water Disinfection

Autori: Lina Vanesa Garcia Peña, Petya Petkova, Rosanna Margalef-Marti, Marc Vives, Lorena Aguilar, Angel Gallegos, Antonio Francesko, Ilana Perelshtein, Aharon Gedanken, Ernest Mendoza, Juan Carlos Casas-Zapata, Jordi Morató, Tzanko Tzanov
Pubblicato in: Industrial & Engineering Chemistry Research, Issue 56/13, 2017, Page(s) 3599-3606, ISSN 0888-5885
DOI: 10.1021/acs.iecr.6b04721

Nanotransformation of Vancomycin Overcomes the Intrinsic Resistance of Gram-Negative Bacteria

Autori: Margarida M. Fernandes, Kristina Ivanova, Javier Hoyo, Sílvia Pérez-Rafael, Antonio Francesko, Tzanko Tzanov
Pubblicato in: ACS Applied Materials & Interfaces, Issue 9/17, 2017, Page(s) 15022-15030, ISSN 1944-8244
DOI: 10.1021/acsami.7b00217

Airborne Nanoparticle Release and Toxicological Risk from Metal-Oxide-Coated Textiles: Toward a Multiscale Safe-by-Design Approach

Autori: Paride Mantecca, Kaja Kasemets, Archana Deokar, Ilana Perelshtein, Aharon Gedanken, Yeon Kyoung Bahk, Baharh Kianfar, Jing Wang
Pubblicato in: Environmental Science & Technology, Issue 51/16, 2017, Page(s) 9305-9317, ISSN 0013-936X
DOI: 10.1021/acs.est.7b02390

Toxicity of DEP and metal oxide nanoparticles mixtures in human lung cells

Autori: A. Zerboni, P. Mantecca
Pubblicato in: Toxicology Letters, Issue 295, 2018, Page(s) S236-S237, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2018.06.987

Antibacterial properties of polypyrrole-treated fabrics by ultrasound deposition

Autori: Diego Omar Sanchez Ramirez, Alessio Varesano, Riccardo Andrea Carletto, Claudia Vineis, Ilana Perelshtein, Michal Natan, Nina Perkas, Ehud Banin, Aharon Gedanken
Pubblicato in: Materials Science and Engineering: C, Issue 102, 2019, Page(s) 164-170, ISSN 0928-4931
DOI: 10.1016/j.msec.2019.04.016

Assessing occupational risk in designs of production processes of nano-materials

Autori: Felice C. Simeone, Magda Blosi, Simona Ortelli, Anna L. Costa
Pubblicato in: NanoImpact, Issue 14, 2019, Page(s) 100149, ISSN 2452-0748
DOI: 10.1016/j.impact.2019.100149

Machine learning prediction of nanoparticle in vitro toxicity: A comparative study of classifiers and ensemble-classifiers using the Copeland Index

Autori: Irini Furxhi, Finbarr Murphy, Martin Mullins, Craig A. Poland
Pubblicato in: Toxicology Letters, Issue 312, 2019, Page(s) 157-166, ISSN 0378-4274
DOI: 10.1016/j.toxlet.2019.05.016

Application of Bayesian networks in determining nanoparticle-induced cellular outcomes using transcriptomics

Autori: Irini Furxhi, Finbarr Murphy, Craig A. Poland, Barry Sheehan, Martin Mullins, Paride Mantecca
Pubblicato in: Nanotoxicology, 2019, Page(s) 1-22, ISSN 1743-5390
DOI: 10.1080/17435390.2019.1595206

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier

Autori: Graziano Colombo, Cristina Cortinovis, Elisa Moschini, Nicholas Bellitto, Maria Chiara Perego, Marco Albonico, Emanuela Astori, Isabella Dalle‐Donne, Alessia Bertero, Aharon Gedanken, Ilana Perelsthein, Paride Mantecca, Francesca Caloni
Pubblicato in: Journal of Applied Toxicology, 2019, ISSN 0260-437X
DOI: 10.1002/jat.3800

In Vitro Toxicity of TiO2:SiO2 Nanocomposites with Different Photocatalytic Properties

Autori: Rossella Bengalli, Simona Ortelli, Magda Blosi, Anna Costa, Paride Mantecca, Luisa Fiandra
Pubblicato in: Nanomaterials, Issue 9/7, 2019, Page(s) 1041, ISSN 2079-4991
DOI: 10.3390/nano9071041

Sonochemical One-Step Synthesis of Polymer-Capped Metal Oxide Nanocolloids: Antibacterial Activity and Cytotoxicity

Autori: Anjani P. Nagvenkar, Ilana Perelshtein, Ylenia Piunno, Paride Mantecca, Aharon Gedanken
Pubblicato in: ACS Omega, Issue 4/9, 2019, Page(s) 13631-13639, ISSN 2470-1343
DOI: 10.1021/acsomega.9b00181

Mixture Effects of Diesel Exhaust and Metal Oxide Nanoparticles in Human Lung A549 Cells

Autori: Zerboni, Bengalli, Baeri, Fiandra, Catelani, Mantecca
Pubblicato in: Nanomaterials, Issue 9/9, 2019, Page(s) 1302, ISSN 2079-4991
DOI: 10.3390/nano9091302

Hazard assessment of polymer-capped CuO and ZnO nanocolloids: A contribution to the safe-by-design implementation of biocidal agents

Autori: Luisa Fiandra, Patrizia Bonfanti, Ylenia Piunno, Anjani P. Nagvenkar, Ilana Perlesthein, Aharon Gedanken, Melissa Saibene, Anita Colombo, Paride Mantecca
Pubblicato in: NanoImpact, Issue 17, 2020, Page(s) 100195, ISSN 2452-0748
DOI: 10.1016/j.impact.2019.100195

Multifunctional ZnO NPs-chitosan-gallic acid hybrid nanocoating to overcome contact lenses associated conditions and discomfort

Autori: Javier Hoyo, Kristina Ivanova, Ester Guaus, Tzanko Tzanov
Pubblicato in: Journal of Colloid and Interface Science, Issue 543, 2019, Page(s) 114-121, ISSN 0021-9797
DOI: 10.1016/j.jcis.2019.02.043

Insulating Thermal and Water-Resistant Hybrid Coating for Fabrics

Autori: Simona Ortelli, Anna Luisa Costa
Pubblicato in: Coatings, Issue 10/1, 2020, Page(s) 72, ISSN 2079-6412
DOI: 10.3390/coatings10010072

Nanotoxicology data for in silico tools: a literature review

Autori: Irini Furxhi, Finbarr Murphy, Martin Mullins, Athanasios Arvanitis, Craig A. Poland
Pubblicato in: Nanotoxicology, 2020, Page(s) 1-26, ISSN 1743-5390
DOI: 10.1080/17435390.2020.1729439

Use of Cotton Textiles Coated by Ir(III) Tetrazole Complexes within Ceramic Silica Nanophases for Photo-Induced Self-Marker and Antibacterial Application

Autori: Ilaria Zanoni, Magda Blosi, Valentina Fiorini, Matteo Crosera, Simona Ortelli, Stefano Stagni, Alessandra Stefan, Sotiris Psilodimitrakopoulos, Emmanuel Stratakis, Francesca Larese Filon, Anna Luisa Costa
Pubblicato in: Nanomaterials, Issue 10/6, 2020, Page(s) 1020, ISSN 2079-4991
DOI: 10.3390/nano10061020

Interaction of Silver-Lignin Nanoparticles With Mammalian Mimetic Membranes

Autori: Javier Hoyo, Kristina Ivanova, Juan Torrent-Burgues, Tzanko Tzanov
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) 439, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00439

Layer‐By‐Layer Coating of Aminocellulose and Quorum Quenching Acylase on Silver Nanoparticles Synergistically Eradicate Bacteria and Their Biofilms

Autori: Aleksandra Ivanova, Kristina Ivanova, Antje Tied, Thomas Heinze, Tzanko Tzanov
Pubblicato in: Advanced Functional Materials, Issue 30/24, 2020, Page(s) 2001284, ISSN 1616-301X
DOI: 10.1002/adfm.202001284

Lipid-lipid interactions of Escherichia coli mimetic inner membrane at human physiological temperature

Autori: Javier Hoyo, Juan Torrent-Burgués,Tzanko Tzanov
Pubblicato in: General physiology and biophysics, Issue 39/02, 2020, Page(s) 195-202, ISSN 1338-4325
DOI: 10.4149/gpb_2019063

In vitro skin toxicity of CuO and ZnO nanoparticles: Application in the safety assessment of antimicrobial coated textiles

Autori: Rossella Bengalli, Alessandra Colantuoni, Ilana Perelshtein, Aharon Gedanken, Maddalena Collini, Paride Mantecca, Luisa Fiandra
Pubblicato in: NanoImpact, Issue 21, 2021, Page(s) 100282, ISSN 2452-0748
DOI: 10.1016/j.impact.2020.100282

Industrial innovation and market opportunities for nano-enabled textiles

Autori: Antonio Andretta; Giuseppe Rosace; Alessio Varesano; Massimo Perucca
Pubblicato in: Nano Innovation 2017, Issue 26-29 September, 2017, 2017

Novel antibacterial polymer-based finishing for textiles

Autori: A. Varesano, C. Vineis, D.O. Sanchez Ramirez
Pubblicato in: MECSPE, Tecnologie per l'innovazione, Industria 4.0, Issue 23-25 March 2017, 2017

Natural and polypyrrole-based antibacterial finishing of textiles

Autori: A. Varesano, C. Vineis, C. Tonetti, D. Omar S. Ramirez, R.A. Carletto
Pubblicato in: Nano Innovation 2017, Issue 26-29 September 2017, 2017

Predicting Nanomaterials toxicity pathways based on genome-wide transcriptomics studies using Bayesian networks

Autori: Irini Furxhi, Finbarr Murphy, Barry Sheehan, Martin Mullins, Paride Mantecca
Pubblicato in: 2018 IEEE 18th International Conference on Nanotechnology (IEEE-NANO), 2018, Page(s) 1-4
DOI: 10.1109/nano.2018.8626300

Polypyrrole Nanoparticles Synthesis and Deposition by “Throwing Stones” for Antibacterial Textiles

Autori: A. Varesano, D.O. Sanchez Ramirez, R.A. Carletto, C. Tonetti, C. Vineis
Pubblicato in: Atti della Conferenza del Dipartimento Scienze Chimiche e Tecnologie dei Materiali, Issue 24-26 September 2018, 2019, Page(s) 149

Heating And Antibacterial Textiles By Polypyrrole Coating

Autori: A. Varesano, D.O. Sanchez Ramirez, C. Tonetti, C. Vineis
Pubblicato in: Atti della Conferenza del Dipartimento Scienze Chimiche e Tecnologie dei Materiali, Issue 28-30 October 2019, 2019, Page(s) 157

Managing occupational safety issues of nanomaterials in manufacturing processes

Autori: Felice C. Simeone, et. al
Pubblicato in: Nanoinnovation2019, Issue 11-14 June 2019, 2019

Monitoring occupational exposure scenarios during the production of nanostructured antibacterial textiles

Autori: Simona Ortelli, et. al.,
Pubblicato in: Nanoinnovation2019, Issue 11-14 June 2019, 2019

Metal-protein nanocomposites with bactericidal and antibiofilm efficacies

Autori: 257th American Chemical Society National Meeting & Exposition. G., Ivanova K., Bassegoda A., Torrent-Burgués J., Tzanov T
Pubblicato in: 257th American Chemical Society National Meeting & Exposition., Issue 31 March – 4 April 2019, 2019

Nanoengineering strategies for Safe by Desing Antimicrobial Materials

Autori: Simona Ortelli, Franco Belosi, Fabrizio Ravegnani, Paride Mantecca, Carlo Baldisserri, Magda Blosi, Felice C. Simeone and Anna L. Costa
Pubblicato in: Monitoring occupational exposure scenarios during the production of nanostructured antibacterial textiles, Issue 11-14 June 2019, 2019

Antimicrobial functionalization of cotton textiles with ZnO NPs and gallic acid embedded in an in-situ sono-enzymatically generated bioadhesive

Autori: Hoyo J., Tzanov T
Pubblicato in: 257th American Chemical Society National Meeting & Exposition, Issue 31 March – 4 April 2019, 2019

Single-step hybrid nanocoating on contact lenses to face associated conditions and discomfort

Autori: Hoyo J., Ivanova K., Guaus E., Tzanov T
Pubblicato in: 257th American Chemical Society National Meeting & Exposition, Issue 31 March – 4 April 2019, 2019

Safe-by-design hybrid nanoparticles of antimicrobial silver, aminocellulose, and quorum quenching acylase eradicate bacteria and their biofilms

Autori: Ivanova A., Ivanova K., Heinze T., Tzanov T.,
Pubblicato in: 257th American Chemical Society National Meeting & Exposition, Issue 31 March – 4 April 2019, 2019

Application of antibacterial textile finishes by sonochemistry and its characterization

Autori: M. Blanes, M. Martínez, A. Romero, M. Canet, F. Fernández, O. Calvo
Pubblicato in: 44 Symposium 2019, AEQCT, Issue 6th, March 2019, 2019

Hybrid nano-antibacterials to control biofilm-associated infections

Autori: Ivanova K, Hoyo J, Tzanov T.
Pubblicato in: 253rd American Chemical Society National Meeting & Exposition, Issue 2-6 April, 2017, 2017

Hybrid nanocoatings of quorum quenching enzyme and antibiotic for prevention of bacterial biofilms

Autori: Ivanova K, Ivanova A, Hoyo J, Tzanov T.
Pubblicato in: IC2AR 2017 Proceedings Book 2nd International Caparica Conference in Antibiotic Resistance, Issue 12-15 June, 2017, 2017

Nanotoxicology meets the industry: the safe-by-design approach

Autori: P. Manteca
Pubblicato in: MECSPE, Tecnologie per l’Innovazione, Industria 4.0, Issue 23-25 March, 2017, 2017

Making the Hospital a Safer Place by Coating of all its Textiles with Antibacterial Nanoparticles

Autori: A. Gedanken
Pubblicato in: NanoWorld Conference, Issue 3-5 April, 2017, 2017

Antibacterial Textiles by spray US

Autori: Carla Silva
Pubblicato in: iTechStyle Summit - 1st International Conference of Textile and Clothing, Issue 13-14 February, 2017, 2017

Antibacterial Coatings on Medical Devices

Autori: Kristina Ivanova, Arnau Bassegoda, Tzanko Tzanov
Pubblicato in: Handbook of Antimicrobial Coatings, 2018, Page(s) 487-507
DOI: 10.1016/b978-0-12-811982-2.00021-4

Inhibition of Quorum-Sensing: A New Paradigm in Controlling Bacterial Virulence and Biofilm Formation

Autori: Aleksandra Ivanova, Kristina Ivanova, Tzanko Tzanov
Pubblicato in: Biotechnological Applications of Quorum Sensing Inhibitors, 2018, Page(s) 3-21
DOI: 10.1007/978-981-10-9026-4_1