Nose to Brain Delivery of Antibodies via the Olfactory Region for the Treatment of Multiple Sclerosis Using Novel Multi-functional Biomaterials Combined with a Medical Device

Project Information

N2B-patch

Grant agreement ID: 721098

DOI 10.3030/721098

Project closed

EC signature date 9 November 2016

Start date 1 January 2017

End date 30 June 2021

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Total cost € 6 472 998,75

EU contribution € 5 325 498,75

Coordinated by

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

Deliverables

Websites, patent fillings, videos etc. (1)

Project video

An N2B-patch project video will be prepared in due time and disseminated via several channels (project website, YouTube, events, exhibitions etc.)

Documents, reports (2)

Project logo and project webpage

In order to create a corporate identity for N2B-patch, a project logo will be designed. It will be used for all dissemination and communication purposes. The Project Website will serve as a primary dissemination platform and will be regularly filled with suitable content for Internet publication.

Dissemination material: project flyer and poster

Dissemination material like a project flyer or leaflet and a project poster will be prepared in due time and disseminated via several channels (project website, YouTube, events, exhibi-tions etc.)

Publications

Peer reviewed articles (7)

A Computational Systems Approach to Rational Design of Nose-to-Brain Delivery of Biopharmaceutics

Author(s): Costas Kiparissides, Athina Vasileiadou, Filippos Karageorgos, Stefania Serpetsi
Published in: Industrial & Engineering Chemistry Research, Issue 59/6, 2020, Page(s) 2548-2565, ISSN 0888-5885
Publisher: American Chemical Society
DOI: 10.1021/acs.iecr.9b04885

»N2B-Patch« – Nose-To-Brain Delivery of an Active Pharmaceutical Ingredient via the Olfactory Region

Author(s): Carmen Gruber Traub
Published in: Drug Designing & Intellectual Properties International Journal, Issue 1/4, 2018, ISSN 2637-4706
Publisher: Lupine Publishers
DOI: 10.32474/ddipij.2018.01.000116

Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

Author(s): Bourganis, Vassilis; Kammona, Olga; Alexopoulos, Aleck; Kiparissides, Costas
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 128, 2018, Page(s) 337-362, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.5281/zenodo.1256646

Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?

Author(s): Simone Ladel, Johannes Flamm, Arghavan Soleimani Zadeh, Dorothea Filzwieser, Julia-Christina Walter, Patrick Schlossbauer, Ralf Kinscherf, Katharina Lischka, Harald Luksch, Katharina Schindowski
Published in: Pharmaceutics, Issue 10/3, 2018, Page(s) 107, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics10030107

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

Author(s): Stella Gänger, Katharina Schindowski
Published in: Pharmaceutics, Issue 10/3, 2018, Page(s) 116, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics10030116

Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650

Author(s): Simone Ladel, Patrick Schlossbauer, Johannes Flamm, Harald Luksch, Boris Mizaikoff, Katharina Schindowski
Published in: Pharmaceutics, Issue 11/8, 2019, Page(s) 367, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11080367

A Computational Model for the Analysis of Spreading of Viscoelastic Droplets over Flat Surfaces

Author(s): Aleck H. Alexopoulos, Costas Kiparissides
Published in: Fluids, Issue 3/4, 2018, Page(s) 78, ISSN 2311-5521
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/fluids3040078