Project description
For strategies in drug-induced metabolic dysfunctions
As a result of lifelong medication treatment, metabolic diseases can develop and severely impact a patient’s health. This is particularly challenging in mental disorders like schizophrenia. However, the evaluation of the risk of drug-induced metabolic dysfunctions remains largely unexplored. With the support of the Marie Skłodowska-Curie Actions, the TREATMENT project will address this issue by establishing a training network. The network will provide young scientists with multidisciplinary knowledge, skills, and tools. Specifically, TREATMENT will integrate pharmacology, metabolism, and mental health research with strategies for designing and validating products and tools. Through fostering inter-sectorial and international careers, the project will promote the development and implementation of personalised medicine tools for effectively treating lifelong medical interventions.
Objective
TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients require life-long medications that subsequently trigger metabolic diseases with a strong negative impact on their health and well-being. To achieve this, and improve adherence to treatments, we will evaluate how short-term antipsychotic drug responses impact long-term metabolic control to identify and validate biomarkers with clinically predictive value for targeting drug induced metabolic dysfunctions. This effort will have added commercial value by enabling the design of predictive marker kits for testing adverse secondary metabolic effects of drugs to be used in pharmacological and medical practice. TREATMENT will provide multidisciplinary knowledge, capabilities and tools to implement this ambitious strategy by the training of young scientists in a program that combines pharmacology, metabolism and mental health research with strategies for product and tool design and validation. Our ultimate goal is to empower the intersectorial and trans-national employability of young scientists across academic, public and private sectors to foster the development and implementation of personalized medicine tools that will provide effective treatment regimens for life long health-care interventions and decrease the risk for development of chronic metabolic diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesclinical medicinepsychiatryschizophrenia
- medical and health sciencesbasic medicinephysiologyhomeostasis
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Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
28006 Madrid
Spain