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Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

Deliverables

Researchers Declarations

Researchers declarations

Supervisory Board of the network

Supervisory Board of the network

Research Training schools/Meetings, and reports 3

Research Training schools/Meetings, and reports 3 (report M21)

Dissemination report 1

Open Dissemination report on scientific publications, presentations of results, networking & public engagement activities (Month 24)

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Publications

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

Author(s): Sergio Rius-Pérez, Salvador Pérez, Pablo Martí-Andrés, María Monsalve, Juan Sastre
Published in: Antioxidants & Redox Signaling, Issue 33/3, 2020, Page(s) 145-165, ISSN 1523-0864
DOI: 10.1089/ars.2019.7975

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

Author(s): Fierro-Fernández, Marta; Miguel, Verónica; Márquez-Expósito, Laura; Nuevo-Tapioles, Cristina; Herrero, J. Ignacio; Blanco-Ruiz, Eva; Tituaña, Jessica; Castillo, Carolina; Cannata, Pablo; Monsalve, María; Ruiz-Ortega, Marta; Ramos, Ricardo; Lamas, Santiago
Published in: The FASEB Journal, Issue 7, 2020, ISSN 1530-6860
DOI: 10.1101/667972

Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis.

Author(s): Garcia-Martinez I, Alen R, Rada P, Valverde AM
Published in: Frontiers in Medicine, 2020, ISSN 2296-858X
DOI: 10.3389/fmed.2020.00395

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

Author(s): Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Julio Manuel Martinez-Moreno, Maria Monsalve, Adrian Mario Ramos, Maria Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belen Sanz
Published in: Biomolecules, Issue 10/2, 2020, Page(s) 347, ISSN 2218-273X
DOI: 10.3390/biom10020347

Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet

Author(s): Luis V. Herrera-Marcos, Sara Sancho-Knapik, Clara Gabás-Rivera, Cristina Barranquero, Sonia Gascón, Eduardo Romanos, Roberto Martínez-Beamonte, María A. Navarro, Joaquín C. Surra, Carmen Arnal, José A. García-de-Jalón, María J. Rodríguez-Yoldi, Manuel Tena-Sempere, Cristina Sánchez-Ramos, María Monsalve, Jesús Osada
Published in: American Journal of Physiology-Endocrinology and Metabolism, Issue 318/2, 2020, Page(s) E249-E261, ISSN 0193-1849
DOI: 10.1152/ajpendo.00199.2019

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

Author(s): Águeda González-Rodríguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, Inés Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, María J. Moreno-Aliaga, Carmelo García-Monzón, Aránzazu Sánchez, Ángela M. Valverde
Published in: Molecular Metabolism, Issue 7, 2018, Page(s) 132-146, ISSN 2212-8778
DOI: 10.1016/j.molmet.2017.10.008

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Author(s): Patricia Rada, Virginia Pardo, Maysa A. Mobasher, Irma García-Martínez, Laura Ruiz, Águeda González-Rodríguez, Cristina Sanchez-Ramos, Jordi Muntané, Susana Alemany, Laura P. James, Kenneth J. Simpson, María Monsalve, Maria Pilar Valdecantos, Ángela M. Valverde
Published in: Antioxidants & Redox Signaling, Issue 28/13, 2018, Page(s) 1187-1208, ISSN 1523-0864
DOI: 10.1089/ars.2017.7373

IGF-1, Inflammation and Retinal Degeneration: A Close Network

Author(s): Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ángela M. Valverde
Published in: Frontiers in Aging Neuroscience, Issue 10, 2018, ISSN 1663-4365
DOI: 10.3389/fnagi.2018.00203

Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney

Author(s): Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani
Published in: Nutrients, Issue 10/6, 2018, Page(s) 689, ISSN 2072-6643
DOI: 10.3390/nu10060689

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects

Author(s): Miriam Saiz-Rodríguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel Román, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina Mejía, María Hernández-Martínez, Francisco Abad-Santos
Published in: Basic & Clinical Pharmacology & Toxicology, 2018, ISSN 1742-7835
DOI: 10.1111/bcpt.13141

Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure

Author(s): Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
Published in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
DOI: 10.1002/cpt.1067

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants

Author(s): Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 123/4, 2018, Page(s) 474-485, ISSN 1742-7835
DOI: 10.1111/bcpt.13031

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B

Author(s): Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde, Lisardo Boscá
Published in: Redox Biology, Issue 17, 2018, Page(s) 213-223, ISSN 2213-2317
DOI: 10.1016/j.redox.2018.04.018

The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants

Author(s): Elena Alcalde-Estévez, Ana I. Arroba, Elena M. Sánchez-Fernández, Carmen Ortiz Mellet, Jose M. García Fernández, Laura Masgrau, Ángela M. Valverde
Published in: Food and Chemical Toxicology, Issue 111, 2018, Page(s) 454-466, ISSN 0278-6915
DOI: 10.1016/j.fct.2017.11.050

Medical and Dietary Uses of N-Acetylcysteine

Author(s): Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Published in: Antioxidants, Issue 8/5, 2019, Page(s) 111, ISSN 2076-3921
DOI: 10.3390/antiox8050111

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

Author(s): Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde
Published in: Redox Biology, Issue 26, 2019, Page(s) 101263, ISSN 2213-2317
DOI: 10.1016/j.redox.2019.101263

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Author(s): Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Published in: Disease Models & Mechanisms, Issue 12/7, 2019, Page(s) dmm038810, ISSN 1754-8403
DOI: 10.1242/dmm.038810

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Author(s): M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo García-Monzón, Borja Lanzón, Javier Rupérez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ángela M. Valverde
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-33949-z

Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?

Author(s): Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
DOI: 10.3389/fphys.2019.00457

Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy

Author(s): Alessandra Stacchiotti, Ilaria Grossi, Raquel García-Gómez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani
Published in: Cells, Issue 8/9, 2019, Page(s) 1053, ISSN 2073-4409
DOI: 10.3390/cells8091053

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

Author(s): Salvador Pérez, Sergio Rius‐Pérez, Isabela Finamor, Pablo Martí‐Andrés, Ignacio Prieto, Raquel García, María Monsalve, Juan Sastre
Published in: The Journal of Pathology, 2018, ISSN 0022-3417
DOI: 10.1002/path.5166

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects

Author(s): Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos
Published in: Journal of Psychopharmacology, Issue 32/11, 2018, Page(s) 1212-1222, ISSN 0269-8811
DOI: 10.1177/0269881118798605

Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

Author(s): Assel Sarsenbayeva, Cátia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira
Published in: Psychoneuroendocrinology, 2019, Page(s) 104445, ISSN 0306-4530
DOI: 10.1016/j.psyneuen.2019.104445

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Author(s): Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Published in: Archives of Medical Science, Issue 15/5, 2019, Page(s) 1184-1194, ISSN 1734-1922
DOI: 10.5114/aoms.2019.87462

Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival

Author(s): Izak Patrik Miller, Ivan Pavlović, Borut Poljšak, Dušan Šuput, Irina Milisav
Published in: Antioxidants, Issue 8/10, 2019, Page(s) 434, ISSN 2076-3921
DOI: 10.3390/antiox8100434

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

Author(s): Diana Grajales, Vitor Ferreira, Ángela M. Valverde
Published in: Cells, Issue 8/11, 2019, Page(s) 1336, ISSN 2073-4409
DOI: 10.3390/cells8111336

Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

Author(s): Vitor Ferreira, Diana Grajales, Ángela M. Valverde
Published in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Issue 1865/2, 2020, Page(s) 158534, ISSN 1388-1981
DOI: 10.1016/j.bbalip.2019.158534

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts

Author(s): Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, María Monsalve
Published in: Free Radical Biology and Medicine, Issue 138, 2019, Page(s) 23-32, ISSN 0891-5849
DOI: 10.1016/j.freeradbiomed.2019.04.015

Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

Author(s): Ignacio Prieto, Carmen Rubio Alarcón, Raquel García-Gómez, Rebeca Berdún, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, M. Begoña Ruiz-Larrea, Mariona Jove, Sebastián Cerdán, María Monsalve
Published in: Redox Biology, Issue 29, 2020, Page(s) 101396, ISSN 2213-2317
DOI: 10.1016/j.redox.2019.101396

Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation

Author(s): Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz
Published in: Talanta, Issue 198, 2019, Page(s) 159-168, ISSN 0039-9140
DOI: 10.1016/j.talanta.2019.01.112

The integrated stress response promotes B7H6 expression

Author(s): Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer Bolsée, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
Published in: Journal of Molecular Medicine, Issue 98/1, 2020, Page(s) 135-148, ISSN 0946-2716
DOI: 10.1007/s00109-019-01859-w

The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells

Author(s): Letícia Selinger Galant, Jamal Rafique, Antônio Luiz Braga, Felipe Camargo Braga, Sumbal Saba, Rafael Radi, João Batista Teixeira da Rocha, Claudio Santi, Maria Monsalve, Marcelo Farina, Andreza Fabro de Bem
Published in: Neurochemical Research, 2020, ISSN 0364-3190
DOI: 10.1007/s11064-020-03026-x

Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells

Author(s): Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh
Published in: Journal of Pharmacology and Experimental Therapeutics, 2020, ISSN 1521-0103
DOI: 10.1124/jpet.119.264481

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Author(s): Rubio, Carmen; Puerto, Marta; García-Rodríquez, Juan J; Lu, Van B; García-Martínez, Irma; Alén, Rosa; Sanmartín-Salinas, Patricia; Toledo-Lobo, M Val; Saiz, Jorge; Ruperez, Javier; Barbas, Coral; Menchén, Luis; Gribble, Fiona; Reimann, Frank; Guijarro, Luis G; Carrascosa, Jose M; Valverde, Ángela M
Published in: nlmid: 101605730, Issue 29, 2020, ISSN 2212-8778
DOI: 10.17863/cam.48676

Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis.

Author(s): M.C. Ovejero-Benito, P. Sánchez-Jiménez, M. Saiz-Rodríguez, S. Martín-Vilchez, T. Cabaleiro, M. Román, D. Ochoa, F. Abad-Santos, A. Reolid, E. Muñoz-Aceituno, M. Llamas-Velasco, E. Daudén, F. Abad-Santos
Published in: IBJ Plus, 2018, ISSN 2531-0151
DOI: 10.24217/2531-0151.18v1s1.00007

Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations.

Author(s): Catía Marques, Assel Sarsenbayeva, Gretha Boersma, Maria João Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, Eugénia Carvalho
Published in: IBJ Plus, 2018, ISSN 2531-0151
DOI: 10.24217/2531-0151.18v1s1.00008