The management of the action (WP1) has been implemented as informed in the GA of the action. All the deliverables and milestones have been submitted and informed on time.
Regarding WP2, fifteen ESRs were recruited following the OTM-R principles. All were then enrolled in PhD programmes of excellence. They have been exposed to a multidisciplinary training programme during 36 months, that included secondments and work visits. Five training Schools and Two Conferences have been organized by the Action. All the ESRs have also participated in dissemination and outreach activities.
Cell based studies, pre-clinical models and clinical trials were conducted to reach the proposed scientific aims in full compliancy with Ethics Regulations. The main findings are:
In the liver (WP3), the SGAs Olanzapine and Aripiprazole were found to inhibit mitochondrial oxidative activity, alter metabolic fluxes, induce insulin resistance, endoplasmic reticulum stress, inflammation and fibrosis.
The characterization of SGAs extra-hepatic tissues metabolic related alterations (WP4)
Identified novel targeted pathological processes. The main affected tissues were, white and brown adipose tissues, heart, pancreas, vasculature, immune system and the CNS.
The correlation of cell-based, pre-clinical and human studies (WP5), allowed the identification of short-term biomarkers of metabolic alterations that predict long-term effects at least in the pre-clinical setting, the human clinical trial is still ongoing at the closure of the action.
The action adhered to the Open Data Pilot, prepared its own Data Management Plan, and it is actively loading the derived data as Open Data in repositories.
TREATMENT has been active in scientific forums, including participation in join-activities, together with other EU-funded ITNs. It has also organized and participated in activities targeting the general public, patient’s associations, secondary and high school students, policy makers, stake holders, etc.
The action has its own web page, a promotional video, prepared several MOOCs and informative videos, and has been present in all main social media.
