Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Researchers Declarations

Researchers declarations

Supervisory Board of the network

Open Research Data Pilot

ORDP: Open Research Data Pilot

Doctoral Degrees

Awarding of doctoral degrees

Research Training schools/Meetings, and reports 3

Research Training schoolsMeetings and reports 3 report M21

Dissemination report 1

Open Dissemination report on scientific publications presentations of results networking public engagement activities Month 24

Dissemination report 2

Open Dissemination report on scientific publications, presentations of results, networking & public engagement activities (Month 48)

Minutes of network meetings 6

Minutes of network meetings 6 report M48

Patents

Patents to protect the commercial use of the results.

Publicaciones

Evaluation of genetic polymorphisms associated with the metabolic effects of aripiprazole and olanzapine/ Evaluación de los polimorfismos genéticos asociados a los efectos metabólicos del aripiprazol y la olanzapina

Autores: Author: Koller, Dóra Advisor: Abad Santos, Francisco (dir.)
Publicado en: 2020
Editor: Universidad Autónoma de Madrid

Effects of the Second Generation Antipsychotics olanzapine and aripiprazole in beta cell functionality and pancreatic islet plasticity

Autores: Diana Grajales Abellán
Publicado en: 2020
Editor: Universidad Autónoma de Madrid

The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue

Autores: Fozia Ahmed, Assel Sarsenbayeva, Petros Katsogiannos, Céline Aguer, Maria J Pereira
Publicado en: Toxicology, Edición 445, 2020, Página(s) 152600, ISSN 0300-483X
Editor: Elsevier BV
DOI: 10.1016/j.tox.2020.152600

Effects of olanzapine and aripiprazole on lipolysis in healthy human subcutaneous adipocytes during short incubations.

Autores: Assel Sarsenbayeva, Catía Marques, Gretha Boersma, Maria João Pereira, Jan Eriksson
Publicado en: IBJ Plus, 2018, ISSN 2531-0151
Editor: IBJ Journals
DOI: 10.24217/2531-0151.18v1s1.00005

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects

Autores: Miriam Saiz‐Rodríguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel Román, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina Mejía, María Hernández‐Martínez, Francisco Abad‐Santos
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 124/3, 2019, Página(s) 321-329, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13141

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice

Autores: Patricia Rada, Alejandra Mosquera, Jordi Muntané, Francisco Ferrandiz, Leocadio Rodriguez-Mañas, Flora de Pablo, Jorge González-Canudas, Ángela M. Valverde
Publicado en: Food and Chemical Toxicology, Edición 123, 2019, Página(s) 470-480, ISSN 0278-6915
Editor: Elsevier BV
DOI: 10.1016/j.fct.2018.11.019

Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism

Autores: Prasad G. Kamble, Susanne Hetty, Milica Vranic, Kristina Almby, Casimiro Castillejo-López, Xesús M. Abalo, Maria J. Pereira, Jan W. Eriksson
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-67293-y

Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Autores: Miriam Saiz-Rodríguez, Susana Almenara, Marcos Navares-Gómez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, María Santos, Gina Mejía, Alberto M. Borobia, Cristina Rodríguez-Antona, Francisco Abad-Santos
Publicado en: Biomedicines, Edición 8/4, 2020, Página(s) 94, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines8040094

Mitophagy in Human Diseases

Autores: Laura Doblado, Claudia Lueck, Claudia Rey, Alejandro K. Samhan-Arias, Ignacio Prieto, Alessandra Stacchiotti, Maria Monsalve
Publicado en: International Journal of Molecular Sciences, Edición 22/8, 2021, Página(s) 3903, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083903

Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics

Autores: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Marcos Navares-Gómez, Elena Santos-Molina, Elena Pintos-Sánchez, Francisco Abad-Santos
Publicado en: Advances in Therapy, Edición 38/2, 2021, Página(s) 1035-1054, ISSN 0741-238X
Editor: Health Communications, Inc.
DOI: 10.1007/s12325-020-01566-w

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

Autores: Sergio Rius-Pérez, Salvador Pérez, Pablo Martí-Andrés, María Monsalve, Juan Sastre
Publicado en: Antioxidants & Redox Signaling, Edición 33/3, 2020, Página(s) 145-165, ISSN 1523-0864
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2019.7975

Aripiprazole reduces liver cell division

Autores: Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisav
Publicado en: PLOS ONE, Edición 15/10, 2020, Página(s) e0240754, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0240754

Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

Autores: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Raquel Garcia-Gomez, Maria Monsalve, Rita Rezzani
Publicado en: Cells, Edición 8/1, 2019, Página(s) 5, ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/cells8010005

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Autores: Patricia Rada, Águeda González-Rodríguez, Carmelo García-Monzón, Ángela M. Valverde
Publicado en: Cell Death & Disease, Edición 11/9, 2020, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-020-03003-w

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

Autores: Fierro-Fernández, Marta; Miguel, Verónica; Márquez-Expósito, Laura; Nuevo-Tapioles, Cristina; Herrero, J. Ignacio; Blanco-Ruiz, Eva; Tituaña, Jessica; Castillo, Carolina; Cannata, Pablo; Monsalve, María; Ruiz-Ortega, Marta; Ramos, Ricardo; Lamas, Santiago
Publicado en: The FASEB Journal, Edición 7, 2020, ISSN 1530-6860
Editor: WILEY ONLINE LIBRARY
DOI: 10.1101/667972

Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers

Autores: Dora Koller, Carmen Belmonte, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Francisco Abad‐Santos
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 126/3, 2020, Página(s) 236-246, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13323

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Autores: Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares, John G. Jones
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-69820-3

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Autores: Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde
Publicado en: Molecular Metabolism, Edición 35, 2020, Página(s) 100954, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.01.018

Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

Autores: Pablo Zubiaur, Paula Soria-Chacartegui, Dora Koller, Marcos Navares-Gómez, Dolores Ochoa, Susana Almenara, Miriam Saiz-Rodríguez, Gina Mejía-Abril, Gonzalo Villapalos-García, Manuel Román, Samuel Martín-Vílchez, Francisco Abad-Santos
Publicado en: Biomedicine & Pharmacotherapy, Edición 133, 2021, Página(s) 111087, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2020.111087

PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

Autores: Miguel Fontecha‐Barriuso, Diego Martín‐Sánchez, Julio M Martinez‐Moreno, Susana Carrasco, Olga Ruiz‐Andrés, Maria Monsalve, Cristina Sanchez‐Ramos, Manuel J Gómez, Marta Ruiz‐Ortega, Maria D Sánchez‐Niño, Pablo Cannata‐Ortiz, Ramiro Cabello, Carmen Gonzalez‐Enguita, Alberto Ortiz, Ana B Sanz
Publicado en: The Journal of Pathology, Edición 249/1, 2019, Página(s) 65-78, ISSN 0022-3417
Editor: John Wiley & Sons Inc.
DOI: 10.1002/path.5282

Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis.

Autores: Garcia-Martinez I, Alen R, Rada P, Valverde AM
Publicado en: Frontiers in Medicine, 2020, ISSN 2296-858X
Editor: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.00395

Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes

Autores: Martin H. Lundqvist, Kristina Almby, Urban Wiklund, Niclas Abrahamsson, Prasad G. Kamble, Maria J. Pereira, Jan W. Eriksson
Publicado en: Diabetologia, Edición 64/3, 2021, Página(s) 641-655, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05332-z

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

Autores: Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Julio Manuel Martinez-Moreno, Maria Monsalve, Adrian Mario Ramos, Maria Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belen Sanz
Publicado en: Biomolecules, Edición 10/2, 2020, Página(s) 347, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom10020347

Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice

Autores: Sergio Rius-Pérez, Isabel Torres-Cuevas, María Monsalve, Francisco J. Miranda, Salvador Pérez
Publicado en: Antioxidants, Edición 9/9, 2020, Página(s) 887, ISSN 2076-3921
Editor: MDPI
DOI: 10.3390/antiox9090887

Targeting Lipid Peroxidation for Cancer Treatment

Autores: Sofia M. Clemente, Oscar H. Martínez-Costa, Maria Monsalve, Alejandro K. Samhan-Arias
Publicado en: Molecules, Edición 25/21, 2020, Página(s) 5144, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25215144

Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

Autores: Assel Sarsenbayeva, Priya Dipta, Martin Lundqvist, Kristina E. Almby, Boaz Tirosh, Giada Di Nunzio, Jan W. Eriksson, Maria J. Pereira
Publicado en: Psychoneuroendocrinology, Edición 125, 2021, Página(s) 105071, ISSN 0306-4530
Editor: Pergamon Press
DOI: 10.1016/j.psyneuen.2020.105071

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C‐isotopomers derived from [U‐ 13 C]fructose and [U‐ 13 C]glucose

Autores: Getachew D. Belew, Giada Di Nunzio, Ludgero Tavares, Joao G. Silva, Alejandra N. Torres, John G. Jones
Publicado en: Magnetic Resonance in Medicine, Edición 84/5, 2020, Página(s) 2765-2771, ISSN 0740-3194
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28286

Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet

Autores: Luis V. Herrera-Marcos, Sara Sancho-Knapik, Clara Gabás-Rivera, Cristina Barranquero, Sonia Gascón, Eduardo Romanos, Roberto Martínez-Beamonte, María A. Navarro, Joaquín C. Surra, Carmen Arnal, José A. García-de-Jalón, María J. Rodríguez-Yoldi, Manuel Tena-Sempere, Cristina Sánchez-Ramos, María Monsalve, Jesús Osada
Publicado en: American Journal of Physiology-Endocrinology and Metabolism, Edición 318/2, 2020, Página(s) E249-E261, ISSN 0193-1849
Editor: American Physiological Society
DOI: 10.1152/ajpendo.00199.2019

Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Autores: Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad-Santos
Publicado en: Journal of Pharmaceutical and Biomedical Analysis, Edición 151, 2018, Página(s) 116-125, ISSN 0731-7085
Editor: Elsevier BV
DOI: 10.1016/j.jpba.2017.12.049

Safety and cardiovascular effects of multiple‐dose administration of aripiprazole and olanzapine in a randomised clinical trial

Autores: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Aneta Wojnicz, Samuel Martín, Daniel Romero‐Palacián, Marcos Navares‐Gómez, Francisco Abad‐Santos
Publicado en: Human Psychopharmacology: Clinical and Experimental, Edición 36/1, 2021, Página(s) 1-12, ISSN 0885-6222
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hup.2761

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

Autores: Florian Hinte, Eelco van Anken, Boaz Tirosh, Wolfram Brune
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.51804

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Autores: Saiz-Rodríguez, Miriam; Ochoa, Dolores; Belmonte, Carmen; Román, Manuel; Vieira de Lara, Danilo; Zubiaur, Pablo; Koller, Dora; Mejía, Gina; Abad-Santos, Francisco
Publicado en: Journal of Psychopharmacology 33(4): 522-531 (2019), Edición 1, 2019, ISSN 0269-8811
Editor: SAGE Publications

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

Autores: Águeda González-Rodríguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, Inés Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, María J. Moreno-Aliaga, Carmelo García-Monzón, Aránzazu Sánchez, Ángela M. Valverde
Publicado en: Molecular Metabolism, Edición 7, 2018, Página(s) 132-146, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.10.008

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Autores: Patricia Rada, Virginia Pardo, Maysa A. Mobasher, Irma García-Martínez, Laura Ruiz, Águeda González-Rodríguez, Cristina Sanchez-Ramos, Jordi Muntané, Susana Alemany, Laura P. James, Kenneth J. Simpson, María Monsalve, Maria Pilar Valdecantos, Ángela M. Valverde
Publicado en: Antioxidants & Redox Signaling, Edición 28/13, 2018, Página(s) 1187-1208, ISSN 1523-0864
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7373

IGF-1, Inflammation and Retinal Degeneration: A Close Network

Autores: Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ángela M. Valverde
Publicado en: Frontiers in Aging Neuroscience, Edición 10, 2018, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00203

Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney

Autores: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani
Publicado en: Nutrients, Edición 10/6, 2018, Página(s) 689, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10060689

Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure

Autores: Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
Publicado en: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
Editor: Nature Publishing Group
DOI: 10.1002/cpt.1067

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants

Autores: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 123/4, 2018, Página(s) 474-485, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13031

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B

Autores: Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde, Lisardo Boscá
Publicado en: Redox Biology, Edición 17, 2018, Página(s) 213-223, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2018.04.018

The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants

Autores: Elena Alcalde-Estévez, Ana I. Arroba, Elena M. Sánchez-Fernández, Carmen Ortiz Mellet, Jose M. García Fernández, Laura Masgrau, Ángela M. Valverde
Publicado en: Food and Chemical Toxicology, Edición 111, 2018, Página(s) 454-466, ISSN 0278-6915
Editor: Elsevier BV
DOI: 10.1016/j.fct.2017.11.050

Medical and Dietary Uses of N-Acetylcysteine

Autores: Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Publicado en: Antioxidants, Edición 8/5, 2019, Página(s) 111, ISSN 2076-3921
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antiox8050111

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

Autores: Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde
Publicado en: Redox Biology, Edición 26, 2019, Página(s) 101263, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2019.101263

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Autores: Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Publicado en: Disease Models & Mechanisms, Edición 12/7, 2019, Página(s) dmm038810, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.038810

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Autores: M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo García-Monzón, Borja Lanzón, Javier Rupérez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ángela M. Valverde
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-33949-z

Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?

Autores: Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson
Publicado en: Frontiers in Physiology, Edición 10, 2019, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00457

Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy

Autores: Alessandra Stacchiotti, Ilaria Grossi, Raquel García-Gómez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani
Publicado en: Cells, Edición 8/9, 2019, Página(s) 1053, ISSN 2073-4409
Editor: Cells
DOI: 10.3390/cells8091053

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

Autores: Salvador Pérez, Sergio Rius‐Pérez, Isabela Finamor, Pablo Martí‐Andrés, Ignacio Prieto, Raquel García, María Monsalve, Juan Sastre
Publicado en: The Journal of Pathology, 2018, ISSN 0022-3417
Editor: John Wiley & Sons Inc.
DOI: 10.1002/path.5166

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects

Autores: Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos
Publicado en: Journal of Psychopharmacology, Edición 32/11, 2018, Página(s) 1212-1222, ISSN 0269-8811
Editor: SAGE Publications
DOI: 10.1177/0269881118798605

Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

Autores: Assel Sarsenbayeva, Cátia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira
Publicado en: Psychoneuroendocrinology, 2019, Página(s) 104445, ISSN 0306-4530
Editor: Pergamon Press
DOI: 10.1016/j.psyneuen.2019.104445

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Autores: Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Publicado en: Archives of Medical Science, Edición 15/5, 2019, Página(s) 1184-1194, ISSN 1734-1922
Editor: Termedia
DOI: 10.5114/aoms.2019.87462

Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival

Autores: Izak Patrik Miller, Ivan Pavlović, Borut Poljšak, Dušan Šuput, Irina Milisav
Publicado en: Antioxidants, Edición 8/10, 2019, Página(s) 434, ISSN 2076-3921
Editor: Antioxidants
DOI: 10.3390/antiox8100434

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

Autores: Diana Grajales, Vitor Ferreira, Ángela M. Valverde
Publicado en: Cells, Edición 8/11, 2019, Página(s) 1336, ISSN 2073-4409
Editor: Cells
DOI: 10.3390/cells8111336

Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

Autores: Vitor Ferreira, Diana Grajales, Ángela M. Valverde
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Edición 1865/2, 2020, Página(s) 158534, ISSN 1388-1981
Editor: Elsevier BV
DOI: 10.1016/j.bbalip.2019.158534

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts

Autores: Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, María Monsalve
Publicado en: Free Radical Biology and Medicine, Edición 138, 2019, Página(s) 23-32, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2019.04.015

Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

Autores: Ignacio Prieto, Carmen Rubio Alarcón, Raquel García-Gómez, Rebeca Berdún, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, M. Begoña Ruiz-Larrea, Mariona Jove, Sebastián Cerdán, María Monsalve
Publicado en: Redox Biology, Edición 29, 2020, Página(s) 101396, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2019.101396

Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation

Autores: Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz
Publicado en: Talanta, Edición 198, 2019, Página(s) 159-168, ISSN 0039-9140
Editor: Elsevier BV
DOI: 10.1016/j.talanta.2019.01.112

The integrated stress response promotes B7H6 expression

Autores: Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer Bolsée, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
Publicado en: Journal of Molecular Medicine, Edición 98/1, 2020, Página(s) 135-148, ISSN 0946-2716
Editor: Springer Verlag
DOI: 10.1007/s00109-019-01859-w

Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

Autores: Mohamed Mahameed, Shatha Boukeileh, Akram Obiedat, Odai Darawshi, Priya Dipta, Amit Rimon, Gordon McLennan, Rosi Fassler, Dana Reichmann, Rotem Karni, Christian Preisinger, Thomas Wilhelm, Michael Huber, Boaz Tirosh
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15067-5

The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells

Autores: Letícia Selinger Galant, Jamal Rafique, Antônio Luiz Braga, Felipe Camargo Braga, Sumbal Saba, Rafael Radi, João Batista Teixeira da Rocha, Claudio Santi, Maria Monsalve, Marcelo Farina, Andreza Fabro de Bem
Publicado en: Neurochemical Research, 2020, ISSN 0364-3190
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-020-03026-x

Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells

Autores: Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh
Publicado en: Journal of Pharmacology and Experimental Therapeutics, 2020, ISSN 1521-0103
Editor: ASPET
DOI: 10.1124/jpet.119.264481

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Autores: Rubio, Carmen; Puerto, Marta; García-Rodríquez, Juan J; Lu, Van B; García-Martínez, Irma; Alén, Rosa; Sanmartín-Salinas, Patricia; Toledo-Lobo, M Val; Saiz, Jorge; Ruperez, Javier; Barbas, Coral; Menchén, Luis; Gribble, Fiona; Reimann, Frank; Guijarro, Luis G; Carrascosa, Jose M; Valverde, Ángela M
Publicado en: Molecular Metabolism, Edición 29, 2020, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.17863/cam.48676

Evaluation of Voriconazole CYP2C19 Phenotype-Guided Dose Adjustments by Physiologically Based Pharmacokinetic Modeling

Autores: Pablo Zubiaur, Lisa A. Kneller, Dolores Ochoa, Gina Mejía, Miriam Saiz-Rodríguez, Alberto M. Borobia, Dora Koller, Irene García García, Marcos Navares-Gómez, Georg Hempel, Francisco Abad-Santos
Publicado en: Clinical Pharmacokinetics, Edición 60/2, 2021, Página(s) 261-270, ISSN 0312-5963
Editor: Adis International Ltd.
DOI: 10.1007/s40262-020-00941-8

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Autores: Miriam Saiz-Rodríguez, Dolores Ochoa, Carmen Belmonte, Manuel Román, Danilo Vieira de Lara, Pablo Zubiaur, Dora Koller, Gina Mejía, Francisco Abad-Santos
Publicado en: Journal of Psychopharmacology, Edición 33/4, 2019, Página(s) 522-531, ISSN 0269-8811
Editor: SAGE Publications
DOI: 10.1177/0269881119827959

The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple‐dose trial

Autores: Dora Koller, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Dolores Ochoa, Susana Almenara, Manuel Román, Daniel Romero‐Palacián, Alejandro Miguel‐Cáceres, Samuel Martín, Marcos Navares‐Gómez, Gina Mejía, Aneta Wojnicz, Francisco Abad‐Santos
Publicado en: British Journal of Clinical Pharmacology, Edición 86/10, 2020, Página(s) 2051-2062, ISSN 0306-5251
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bcp.14300

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers

Autores: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Dora Koller, María Talegón, María C. Ovejero-Benito, Rosario López-Rodríguez, Teresa Cabaleiro, Francisco Abad-Santos
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 122/5, 2018, Página(s) 501-511, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12938

Methodological Approach for the Evaluation of FOXO as a Positive Regulator of Antioxidant Genes

Autores: María Monsalve, Ignacio Prieto, Andreza Fabro de Bem, Yolanda Olmos
Publicado en: FOXO Transcription Factors - Methods and Protocols, Edición 1890, 2019, Página(s) 61-76, ISBN 978-1-4939-8899-0
Editor: Springer New York
DOI: 10.1007/978-1-4939-8900-3_6

Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis.

Autores: M.C. Ovejero-Benito, P. Sánchez-Jiménez, M. Saiz-Rodríguez, S. Martín-Vilchez, T. Cabaleiro, M. Román, D. Ochoa, F. Abad-Santos, A. Reolid, E. Muñoz-Aceituno, M. Llamas-Velasco, E. Daudén, F. Abad-Santos
Publicado en: IBJ Plus, 2018, ISSN 2531-0151
Editor: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00007

Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations.

Autores: Catía Marques, Assel Sarsenbayeva, Gretha Boersma, Maria João Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, Eugénia Carvalho
Publicado en: IBJ Plus, 2018, ISSN 2531-0151
Editor: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00008

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