Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Researchers Declarations

Researchers declarations

Supervisory Board of the network

Open Research Data Pilot

ORDP: Open Research Data Pilot

Doctoral Degrees

Awarding of doctoral degrees

Research Training schools/Meetings, and reports 3

Research Training schoolsMeetings and reports 3 report M21

Dissemination report 1

Open Dissemination report on scientific publications presentations of results networking public engagement activities Month 24

Dissemination report 2

Open Dissemination report on scientific publications, presentations of results, networking & public engagement activities (Month 48)

Minutes of network meetings 6

Minutes of network meetings 6 report M48

Patents

Patents to protect the commercial use of the results.

Pubblicazioni

Evaluation of genetic polymorphisms associated with the metabolic effects of aripiprazole and olanzapine/ Evaluación de los polimorfismos genéticos asociados a los efectos metabólicos del aripiprazol y la olanzapina

Autori: Author: Koller, Dóra Advisor: Abad Santos, Francisco (dir.)
Pubblicato in: 2020
Editore: Universidad Autónoma de Madrid

Effects of the Second Generation Antipsychotics olanzapine and aripiprazole in beta cell functionality and pancreatic islet plasticity

Autori: Diana Grajales Abellán
Pubblicato in: 2020
Editore: Universidad Autónoma de Madrid

The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue

Autori: Fozia Ahmed, Assel Sarsenbayeva, Petros Katsogiannos, Céline Aguer, Maria J Pereira
Pubblicato in: Toxicology, Numero 445, 2020, Pagina/e 152600, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/j.tox.2020.152600

Effects of olanzapine and aripiprazole on lipolysis in healthy human subcutaneous adipocytes during short incubations.

Autori: Assel Sarsenbayeva, Catía Marques, Gretha Boersma, Maria João Pereira, Jan Eriksson
Pubblicato in: IBJ Plus, 2018, ISSN 2531-0151
Editore: IBJ Journals
DOI: 10.24217/2531-0151.18v1s1.00005

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects

Autori: Miriam Saiz‐Rodríguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel Román, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina Mejía, María Hernández‐Martínez, Francisco Abad‐Santos
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 124/3, 2019, Pagina/e 321-329, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13141

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice

Autori: Patricia Rada, Alejandra Mosquera, Jordi Muntané, Francisco Ferrandiz, Leocadio Rodriguez-Mañas, Flora de Pablo, Jorge González-Canudas, Ángela M. Valverde
Pubblicato in: Food and Chemical Toxicology, Numero 123, 2019, Pagina/e 470-480, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/j.fct.2018.11.019

Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism

Autori: Prasad G. Kamble, Susanne Hetty, Milica Vranic, Kristina Almby, Casimiro Castillejo-López, Xesús M. Abalo, Maria J. Pereira, Jan W. Eriksson
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-67293-y

Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Autori: Miriam Saiz-Rodríguez, Susana Almenara, Marcos Navares-Gómez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, María Santos, Gina Mejía, Alberto M. Borobia, Cristina Rodríguez-Antona, Francisco Abad-Santos
Pubblicato in: Biomedicines, Numero 8/4, 2020, Pagina/e 94, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines8040094

Mitophagy in Human Diseases

Autori: Laura Doblado, Claudia Lueck, Claudia Rey, Alejandro K. Samhan-Arias, Ignacio Prieto, Alessandra Stacchiotti, Maria Monsalve
Pubblicato in: International Journal of Molecular Sciences, Numero 22/8, 2021, Pagina/e 3903, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083903

Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics

Autori: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Marcos Navares-Gómez, Elena Santos-Molina, Elena Pintos-Sánchez, Francisco Abad-Santos
Pubblicato in: Advances in Therapy, Numero 38/2, 2021, Pagina/e 1035-1054, ISSN 0741-238X
Editore: Health Communications, Inc.
DOI: 10.1007/s12325-020-01566-w

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

Autori: Sergio Rius-Pérez, Salvador Pérez, Pablo Martí-Andrés, María Monsalve, Juan Sastre
Pubblicato in: Antioxidants & Redox Signaling, Numero 33/3, 2020, Pagina/e 145-165, ISSN 1523-0864
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2019.7975

Aripiprazole reduces liver cell division

Autori: Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisav
Pubblicato in: PLOS ONE, Numero 15/10, 2020, Pagina/e e0240754, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0240754

Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

Autori: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Raquel Garcia-Gomez, Maria Monsalve, Rita Rezzani
Pubblicato in: Cells, Numero 8/1, 2019, Pagina/e 5, ISSN 2073-4409
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/cells8010005

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Autori: Patricia Rada, Águeda González-Rodríguez, Carmelo García-Monzón, Ángela M. Valverde
Pubblicato in: Cell Death & Disease, Numero 11/9, 2020, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-020-03003-w

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

Autori: Fierro-Fernández, Marta; Miguel, Verónica; Márquez-Expósito, Laura; Nuevo-Tapioles, Cristina; Herrero, J. Ignacio; Blanco-Ruiz, Eva; Tituaña, Jessica; Castillo, Carolina; Cannata, Pablo; Monsalve, María; Ruiz-Ortega, Marta; Ramos, Ricardo; Lamas, Santiago
Pubblicato in: The FASEB Journal, Numero 7, 2020, ISSN 1530-6860
Editore: WILEY ONLINE LIBRARY
DOI: 10.1101/667972

Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers

Autori: Dora Koller, Carmen Belmonte, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Francisco Abad‐Santos
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 126/3, 2020, Pagina/e 236-246, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13323

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Autori: Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares, John G. Jones
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-69820-3

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Autori: Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde
Pubblicato in: Molecular Metabolism, Numero 35, 2020, Pagina/e 100954, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.01.018

Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

Autori: Pablo Zubiaur, Paula Soria-Chacartegui, Dora Koller, Marcos Navares-Gómez, Dolores Ochoa, Susana Almenara, Miriam Saiz-Rodríguez, Gina Mejía-Abril, Gonzalo Villapalos-García, Manuel Román, Samuel Martín-Vílchez, Francisco Abad-Santos
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 133, 2021, Pagina/e 111087, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2020.111087

PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

Autori: Miguel Fontecha‐Barriuso, Diego Martín‐Sánchez, Julio M Martinez‐Moreno, Susana Carrasco, Olga Ruiz‐Andrés, Maria Monsalve, Cristina Sanchez‐Ramos, Manuel J Gómez, Marta Ruiz‐Ortega, Maria D Sánchez‐Niño, Pablo Cannata‐Ortiz, Ramiro Cabello, Carmen Gonzalez‐Enguita, Alberto Ortiz, Ana B Sanz
Pubblicato in: The Journal of Pathology, Numero 249/1, 2019, Pagina/e 65-78, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5282

Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis.

Autori: Garcia-Martinez I, Alen R, Rada P, Valverde AM
Pubblicato in: Frontiers in Medicine, 2020, ISSN 2296-858X
Editore: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.00395

Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes

Autori: Martin H. Lundqvist, Kristina Almby, Urban Wiklund, Niclas Abrahamsson, Prasad G. Kamble, Maria J. Pereira, Jan W. Eriksson
Pubblicato in: Diabetologia, Numero 64/3, 2021, Pagina/e 641-655, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05332-z

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

Autori: Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Julio Manuel Martinez-Moreno, Maria Monsalve, Adrian Mario Ramos, Maria Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belen Sanz
Pubblicato in: Biomolecules, Numero 10/2, 2020, Pagina/e 347, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom10020347

Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice

Autori: Sergio Rius-Pérez, Isabel Torres-Cuevas, María Monsalve, Francisco J. Miranda, Salvador Pérez
Pubblicato in: Antioxidants, Numero 9/9, 2020, Pagina/e 887, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox9090887

Targeting Lipid Peroxidation for Cancer Treatment

Autori: Sofia M. Clemente, Oscar H. Martínez-Costa, Maria Monsalve, Alejandro K. Samhan-Arias
Pubblicato in: Molecules, Numero 25/21, 2020, Pagina/e 5144, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25215144

Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

Autori: Assel Sarsenbayeva, Priya Dipta, Martin Lundqvist, Kristina E. Almby, Boaz Tirosh, Giada Di Nunzio, Jan W. Eriksson, Maria J. Pereira
Pubblicato in: Psychoneuroendocrinology, Numero 125, 2021, Pagina/e 105071, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2020.105071

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C‐isotopomers derived from [U‐ 13 C]fructose and [U‐ 13 C]glucose

Autori: Getachew D. Belew, Giada Di Nunzio, Ludgero Tavares, Joao G. Silva, Alejandra N. Torres, John G. Jones
Pubblicato in: Magnetic Resonance in Medicine, Numero 84/5, 2020, Pagina/e 2765-2771, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28286

Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet

Autori: Luis V. Herrera-Marcos, Sara Sancho-Knapik, Clara Gabás-Rivera, Cristina Barranquero, Sonia Gascón, Eduardo Romanos, Roberto Martínez-Beamonte, María A. Navarro, Joaquín C. Surra, Carmen Arnal, José A. García-de-Jalón, María J. Rodríguez-Yoldi, Manuel Tena-Sempere, Cristina Sánchez-Ramos, María Monsalve, Jesús Osada
Pubblicato in: American Journal of Physiology-Endocrinology and Metabolism, Numero 318/2, 2020, Pagina/e E249-E261, ISSN 0193-1849
Editore: American Physiological Society
DOI: 10.1152/ajpendo.00199.2019

Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Autori: Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad-Santos
Pubblicato in: Journal of Pharmaceutical and Biomedical Analysis, Numero 151, 2018, Pagina/e 116-125, ISSN 0731-7085
Editore: Elsevier BV
DOI: 10.1016/j.jpba.2017.12.049

Safety and cardiovascular effects of multiple‐dose administration of aripiprazole and olanzapine in a randomised clinical trial

Autori: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Aneta Wojnicz, Samuel Martín, Daniel Romero‐Palacián, Marcos Navares‐Gómez, Francisco Abad‐Santos
Pubblicato in: Human Psychopharmacology: Clinical and Experimental, Numero 36/1, 2021, Pagina/e 1-12, ISSN 0885-6222
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hup.2761

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

Autori: Florian Hinte, Eelco van Anken, Boaz Tirosh, Wolfram Brune
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.51804

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Autori: Saiz-Rodríguez, Miriam; Ochoa, Dolores; Belmonte, Carmen; Román, Manuel; Vieira de Lara, Danilo; Zubiaur, Pablo; Koller, Dora; Mejía, Gina; Abad-Santos, Francisco
Pubblicato in: Journal of Psychopharmacology 33(4): 522-531 (2019), Numero 1, 2019, ISSN 0269-8811
Editore: SAGE Publications

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

Autori: Águeda González-Rodríguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, Inés Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, María J. Moreno-Aliaga, Carmelo García-Monzón, Aránzazu Sánchez, Ángela M. Valverde
Pubblicato in: Molecular Metabolism, Numero 7, 2018, Pagina/e 132-146, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.10.008

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Autori: Patricia Rada, Virginia Pardo, Maysa A. Mobasher, Irma García-Martínez, Laura Ruiz, Águeda González-Rodríguez, Cristina Sanchez-Ramos, Jordi Muntané, Susana Alemany, Laura P. James, Kenneth J. Simpson, María Monsalve, Maria Pilar Valdecantos, Ángela M. Valverde
Pubblicato in: Antioxidants & Redox Signaling, Numero 28/13, 2018, Pagina/e 1187-1208, ISSN 1523-0864
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7373

IGF-1, Inflammation and Retinal Degeneration: A Close Network

Autori: Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ángela M. Valverde
Pubblicato in: Frontiers in Aging Neuroscience, Numero 10, 2018, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00203

Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney

Autori: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani
Pubblicato in: Nutrients, Numero 10/6, 2018, Pagina/e 689, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10060689

Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure

Autori: Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
Pubblicato in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.1067

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants

Autori: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 123/4, 2018, Pagina/e 474-485, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13031

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B

Autori: Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde, Lisardo Boscá
Pubblicato in: Redox Biology, Numero 17, 2018, Pagina/e 213-223, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2018.04.018

The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants

Autori: Elena Alcalde-Estévez, Ana I. Arroba, Elena M. Sánchez-Fernández, Carmen Ortiz Mellet, Jose M. García Fernández, Laura Masgrau, Ángela M. Valverde
Pubblicato in: Food and Chemical Toxicology, Numero 111, 2018, Pagina/e 454-466, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/j.fct.2017.11.050

Medical and Dietary Uses of N-Acetylcysteine

Autori: Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Pubblicato in: Antioxidants, Numero 8/5, 2019, Pagina/e 111, ISSN 2076-3921
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antiox8050111

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

Autori: Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde
Pubblicato in: Redox Biology, Numero 26, 2019, Pagina/e 101263, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2019.101263

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Autori: Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Pubblicato in: Disease Models & Mechanisms, Numero 12/7, 2019, Pagina/e dmm038810, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.038810

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Autori: M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo García-Monzón, Borja Lanzón, Javier Rupérez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ángela M. Valverde
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-33949-z

Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?

Autori: Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00457

Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy

Autori: Alessandra Stacchiotti, Ilaria Grossi, Raquel García-Gómez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani
Pubblicato in: Cells, Numero 8/9, 2019, Pagina/e 1053, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells8091053

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

Autori: Salvador Pérez, Sergio Rius‐Pérez, Isabela Finamor, Pablo Martí‐Andrés, Ignacio Prieto, Raquel García, María Monsalve, Juan Sastre
Pubblicato in: The Journal of Pathology, 2018, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5166

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects

Autori: Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos
Pubblicato in: Journal of Psychopharmacology, Numero 32/11, 2018, Pagina/e 1212-1222, ISSN 0269-8811
Editore: SAGE Publications
DOI: 10.1177/0269881118798605

Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

Autori: Assel Sarsenbayeva, Cátia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira
Pubblicato in: Psychoneuroendocrinology, 2019, Pagina/e 104445, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2019.104445

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Autori: Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Pubblicato in: Archives of Medical Science, Numero 15/5, 2019, Pagina/e 1184-1194, ISSN 1734-1922
Editore: Termedia
DOI: 10.5114/aoms.2019.87462

Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival

Autori: Izak Patrik Miller, Ivan Pavlović, Borut Poljšak, Dušan Šuput, Irina Milisav
Pubblicato in: Antioxidants, Numero 8/10, 2019, Pagina/e 434, ISSN 2076-3921
Editore: Antioxidants
DOI: 10.3390/antiox8100434

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

Autori: Diana Grajales, Vitor Ferreira, Ángela M. Valverde
Pubblicato in: Cells, Numero 8/11, 2019, Pagina/e 1336, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells8111336

Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

Autori: Vitor Ferreira, Diana Grajales, Ángela M. Valverde
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Numero 1865/2, 2020, Pagina/e 158534, ISSN 1388-1981
Editore: Elsevier BV
DOI: 10.1016/j.bbalip.2019.158534

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts

Autori: Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, María Monsalve
Pubblicato in: Free Radical Biology and Medicine, Numero 138, 2019, Pagina/e 23-32, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2019.04.015

Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

Autori: Ignacio Prieto, Carmen Rubio Alarcón, Raquel García-Gómez, Rebeca Berdún, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, M. Begoña Ruiz-Larrea, Mariona Jove, Sebastián Cerdán, María Monsalve
Pubblicato in: Redox Biology, Numero 29, 2020, Pagina/e 101396, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2019.101396

Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation

Autori: Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz
Pubblicato in: Talanta, Numero 198, 2019, Pagina/e 159-168, ISSN 0039-9140
Editore: Elsevier BV
DOI: 10.1016/j.talanta.2019.01.112

The integrated stress response promotes B7H6 expression

Autori: Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer Bolsée, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
Pubblicato in: Journal of Molecular Medicine, Numero 98/1, 2020, Pagina/e 135-148, ISSN 0946-2716
Editore: Springer Verlag
DOI: 10.1007/s00109-019-01859-w

Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

Autori: Mohamed Mahameed, Shatha Boukeileh, Akram Obiedat, Odai Darawshi, Priya Dipta, Amit Rimon, Gordon McLennan, Rosi Fassler, Dana Reichmann, Rotem Karni, Christian Preisinger, Thomas Wilhelm, Michael Huber, Boaz Tirosh
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15067-5

The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells

Autori: Letícia Selinger Galant, Jamal Rafique, Antônio Luiz Braga, Felipe Camargo Braga, Sumbal Saba, Rafael Radi, João Batista Teixeira da Rocha, Claudio Santi, Maria Monsalve, Marcelo Farina, Andreza Fabro de Bem
Pubblicato in: Neurochemical Research, 2020, ISSN 0364-3190
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-020-03026-x

Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells

Autori: Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh
Pubblicato in: Journal of Pharmacology and Experimental Therapeutics, 2020, ISSN 1521-0103
Editore: ASPET
DOI: 10.1124/jpet.119.264481

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Autori: Rubio, Carmen; Puerto, Marta; García-Rodríquez, Juan J; Lu, Van B; García-Martínez, Irma; Alén, Rosa; Sanmartín-Salinas, Patricia; Toledo-Lobo, M Val; Saiz, Jorge; Ruperez, Javier; Barbas, Coral; Menchén, Luis; Gribble, Fiona; Reimann, Frank; Guijarro, Luis G; Carrascosa, Jose M; Valverde, Ángela M
Pubblicato in: Molecular Metabolism, Numero 29, 2020, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.17863/cam.48676

Evaluation of Voriconazole CYP2C19 Phenotype-Guided Dose Adjustments by Physiologically Based Pharmacokinetic Modeling

Autori: Pablo Zubiaur, Lisa A. Kneller, Dolores Ochoa, Gina Mejía, Miriam Saiz-Rodríguez, Alberto M. Borobia, Dora Koller, Irene García García, Marcos Navares-Gómez, Georg Hempel, Francisco Abad-Santos
Pubblicato in: Clinical Pharmacokinetics, Numero 60/2, 2021, Pagina/e 261-270, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-020-00941-8

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Autori: Miriam Saiz-Rodríguez, Dolores Ochoa, Carmen Belmonte, Manuel Román, Danilo Vieira de Lara, Pablo Zubiaur, Dora Koller, Gina Mejía, Francisco Abad-Santos
Pubblicato in: Journal of Psychopharmacology, Numero 33/4, 2019, Pagina/e 522-531, ISSN 0269-8811
Editore: SAGE Publications
DOI: 10.1177/0269881119827959

The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple‐dose trial

Autori: Dora Koller, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Dolores Ochoa, Susana Almenara, Manuel Román, Daniel Romero‐Palacián, Alejandro Miguel‐Cáceres, Samuel Martín, Marcos Navares‐Gómez, Gina Mejía, Aneta Wojnicz, Francisco Abad‐Santos
Pubblicato in: British Journal of Clinical Pharmacology, Numero 86/10, 2020, Pagina/e 2051-2062, ISSN 0306-5251
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bcp.14300

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers

Autori: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Dora Koller, María Talegón, María C. Ovejero-Benito, Rosario López-Rodríguez, Teresa Cabaleiro, Francisco Abad-Santos
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 122/5, 2018, Pagina/e 501-511, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12938

Methodological Approach for the Evaluation of FOXO as a Positive Regulator of Antioxidant Genes

Autori: María Monsalve, Ignacio Prieto, Andreza Fabro de Bem, Yolanda Olmos
Pubblicato in: FOXO Transcription Factors - Methods and Protocols, Numero 1890, 2019, Pagina/e 61-76, ISBN 978-1-4939-8899-0
Editore: Springer New York
DOI: 10.1007/978-1-4939-8900-3_6

Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis.

Autori: M.C. Ovejero-Benito, P. Sánchez-Jiménez, M. Saiz-Rodríguez, S. Martín-Vilchez, T. Cabaleiro, M. Román, D. Ochoa, F. Abad-Santos, A. Reolid, E. Muñoz-Aceituno, M. Llamas-Velasco, E. Daudén, F. Abad-Santos
Pubblicato in: IBJ Plus, 2018, ISSN 2531-0151
Editore: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00007

Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations.

Autori: Catía Marques, Assel Sarsenbayeva, Gretha Boersma, Maria João Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, Eugénia Carvalho
Pubblicato in: IBJ Plus, 2018, ISSN 2531-0151
Editore: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00008

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