Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Researchers Declarations

Researchers declarations

Supervisory Board of the network

Open Research Data Pilot

ORDP: Open Research Data Pilot

Doctoral Degrees

Awarding of doctoral degrees

Research Training schools/Meetings, and reports 3

Research Training schoolsMeetings and reports 3 report M21

Dissemination report 1

Open Dissemination report on scientific publications presentations of results networking public engagement activities Month 24

Dissemination report 2

Open Dissemination report on scientific publications, presentations of results, networking & public engagement activities (Month 48)

Minutes of network meetings 6

Minutes of network meetings 6 report M48

Patents

Patents to protect the commercial use of the results.

Publications

Evaluation of genetic polymorphisms associated with the metabolic effects of aripiprazole and olanzapine/ Evaluación de los polimorfismos genéticos asociados a los efectos metabólicos del aripiprazol y la olanzapina

Auteurs: Author: Koller, Dóra Advisor: Abad Santos, Francisco (dir.)
Publié dans: 2020
Éditeur: Universidad Autónoma de Madrid

Effects of the Second Generation Antipsychotics olanzapine and aripiprazole in beta cell functionality and pancreatic islet plasticity

Auteurs: Diana Grajales Abellán
Publié dans: 2020
Éditeur: Universidad Autónoma de Madrid

The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue

Auteurs: Fozia Ahmed, Assel Sarsenbayeva, Petros Katsogiannos, Céline Aguer, Maria J Pereira
Publié dans: Toxicology, Numéro 445, 2020, Page(s) 152600, ISSN 0300-483X
Éditeur: Elsevier BV
DOI: 10.1016/j.tox.2020.152600

Effects of olanzapine and aripiprazole on lipolysis in healthy human subcutaneous adipocytes during short incubations.

Auteurs: Assel Sarsenbayeva, Catía Marques, Gretha Boersma, Maria João Pereira, Jan Eriksson
Publié dans: IBJ Plus, 2018, ISSN 2531-0151
Éditeur: IBJ Journals
DOI: 10.24217/2531-0151.18v1s1.00005

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects

Auteurs: Miriam Saiz‐Rodríguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel Román, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina Mejía, María Hernández‐Martínez, Francisco Abad‐Santos
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 124/3, 2019, Page(s) 321-329, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13141

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice

Auteurs: Patricia Rada, Alejandra Mosquera, Jordi Muntané, Francisco Ferrandiz, Leocadio Rodriguez-Mañas, Flora de Pablo, Jorge González-Canudas, Ángela M. Valverde
Publié dans: Food and Chemical Toxicology, Numéro 123, 2019, Page(s) 470-480, ISSN 0278-6915
Éditeur: Elsevier BV
DOI: 10.1016/j.fct.2018.11.019

Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism

Auteurs: Prasad G. Kamble, Susanne Hetty, Milica Vranic, Kristina Almby, Casimiro Castillejo-López, Xesús M. Abalo, Maria J. Pereira, Jan W. Eriksson
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-67293-y

Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Auteurs: Miriam Saiz-Rodríguez, Susana Almenara, Marcos Navares-Gómez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, María Santos, Gina Mejía, Alberto M. Borobia, Cristina Rodríguez-Antona, Francisco Abad-Santos
Publié dans: Biomedicines, Numéro 8/4, 2020, Page(s) 94, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines8040094

Mitophagy in Human Diseases

Auteurs: Laura Doblado, Claudia Lueck, Claudia Rey, Alejandro K. Samhan-Arias, Ignacio Prieto, Alessandra Stacchiotti, Maria Monsalve
Publié dans: International Journal of Molecular Sciences, Numéro 22/8, 2021, Page(s) 3903, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083903

Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics

Auteurs: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Marcos Navares-Gómez, Elena Santos-Molina, Elena Pintos-Sánchez, Francisco Abad-Santos
Publié dans: Advances in Therapy, Numéro 38/2, 2021, Page(s) 1035-1054, ISSN 0741-238X
Éditeur: Health Communications, Inc.
DOI: 10.1007/s12325-020-01566-w

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

Auteurs: Sergio Rius-Pérez, Salvador Pérez, Pablo Martí-Andrés, María Monsalve, Juan Sastre
Publié dans: Antioxidants & Redox Signaling, Numéro 33/3, 2020, Page(s) 145-165, ISSN 1523-0864
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2019.7975

Aripiprazole reduces liver cell division

Auteurs: Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisav
Publié dans: PLOS ONE, Numéro 15/10, 2020, Page(s) e0240754, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0240754

Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

Auteurs: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Raquel Garcia-Gomez, Maria Monsalve, Rita Rezzani
Publié dans: Cells, Numéro 8/1, 2019, Page(s) 5, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/cells8010005

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Auteurs: Patricia Rada, Águeda González-Rodríguez, Carmelo García-Monzón, Ángela M. Valverde
Publié dans: Cell Death & Disease, Numéro 11/9, 2020, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-020-03003-w

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

Auteurs: Fierro-Fernández, Marta; Miguel, Verónica; Márquez-Expósito, Laura; Nuevo-Tapioles, Cristina; Herrero, J. Ignacio; Blanco-Ruiz, Eva; Tituaña, Jessica; Castillo, Carolina; Cannata, Pablo; Monsalve, María; Ruiz-Ortega, Marta; Ramos, Ricardo; Lamas, Santiago
Publié dans: The FASEB Journal, Numéro 7, 2020, ISSN 1530-6860
Éditeur: WILEY ONLINE LIBRARY
DOI: 10.1101/667972

Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers

Auteurs: Dora Koller, Carmen Belmonte, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Francisco Abad‐Santos
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 126/3, 2020, Page(s) 236-246, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13323

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Auteurs: Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares, John G. Jones
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-69820-3

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Auteurs: Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde
Publié dans: Molecular Metabolism, Numéro 35, 2020, Page(s) 100954, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.01.018

Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

Auteurs: Pablo Zubiaur, Paula Soria-Chacartegui, Dora Koller, Marcos Navares-Gómez, Dolores Ochoa, Susana Almenara, Miriam Saiz-Rodríguez, Gina Mejía-Abril, Gonzalo Villapalos-García, Manuel Román, Samuel Martín-Vílchez, Francisco Abad-Santos
Publié dans: Biomedicine & Pharmacotherapy, Numéro 133, 2021, Page(s) 111087, ISSN 0753-3322
Éditeur: Elsevier Masson
DOI: 10.1016/j.biopha.2020.111087

PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

Auteurs: Miguel Fontecha‐Barriuso, Diego Martín‐Sánchez, Julio M Martinez‐Moreno, Susana Carrasco, Olga Ruiz‐Andrés, Maria Monsalve, Cristina Sanchez‐Ramos, Manuel J Gómez, Marta Ruiz‐Ortega, Maria D Sánchez‐Niño, Pablo Cannata‐Ortiz, Ramiro Cabello, Carmen Gonzalez‐Enguita, Alberto Ortiz, Ana B Sanz
Publié dans: The Journal of Pathology, Numéro 249/1, 2019, Page(s) 65-78, ISSN 0022-3417
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/path.5282

Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis.

Auteurs: Garcia-Martinez I, Alen R, Rada P, Valverde AM
Publié dans: Frontiers in Medicine, 2020, ISSN 2296-858X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.00395

Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes

Auteurs: Martin H. Lundqvist, Kristina Almby, Urban Wiklund, Niclas Abrahamsson, Prasad G. Kamble, Maria J. Pereira, Jan W. Eriksson
Publié dans: Diabetologia, Numéro 64/3, 2021, Page(s) 641-655, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05332-z

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

Auteurs: Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Julio Manuel Martinez-Moreno, Maria Monsalve, Adrian Mario Ramos, Maria Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belen Sanz
Publié dans: Biomolecules, Numéro 10/2, 2020, Page(s) 347, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom10020347

Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice

Auteurs: Sergio Rius-Pérez, Isabel Torres-Cuevas, María Monsalve, Francisco J. Miranda, Salvador Pérez
Publié dans: Antioxidants, Numéro 9/9, 2020, Page(s) 887, ISSN 2076-3921
Éditeur: MDPI
DOI: 10.3390/antiox9090887

Targeting Lipid Peroxidation for Cancer Treatment

Auteurs: Sofia M. Clemente, Oscar H. Martínez-Costa, Maria Monsalve, Alejandro K. Samhan-Arias
Publié dans: Molecules, Numéro 25/21, 2020, Page(s) 5144, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25215144

Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

Auteurs: Assel Sarsenbayeva, Priya Dipta, Martin Lundqvist, Kristina E. Almby, Boaz Tirosh, Giada Di Nunzio, Jan W. Eriksson, Maria J. Pereira
Publié dans: Psychoneuroendocrinology, Numéro 125, 2021, Page(s) 105071, ISSN 0306-4530
Éditeur: Pergamon Press
DOI: 10.1016/j.psyneuen.2020.105071

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C‐isotopomers derived from [U‐ 13 C]fructose and [U‐ 13 C]glucose

Auteurs: Getachew D. Belew, Giada Di Nunzio, Ludgero Tavares, Joao G. Silva, Alejandra N. Torres, John G. Jones
Publié dans: Magnetic Resonance in Medicine, Numéro 84/5, 2020, Page(s) 2765-2771, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28286

Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet

Auteurs: Luis V. Herrera-Marcos, Sara Sancho-Knapik, Clara Gabás-Rivera, Cristina Barranquero, Sonia Gascón, Eduardo Romanos, Roberto Martínez-Beamonte, María A. Navarro, Joaquín C. Surra, Carmen Arnal, José A. García-de-Jalón, María J. Rodríguez-Yoldi, Manuel Tena-Sempere, Cristina Sánchez-Ramos, María Monsalve, Jesús Osada
Publié dans: American Journal of Physiology-Endocrinology and Metabolism, Numéro 318/2, 2020, Page(s) E249-E261, ISSN 0193-1849
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00199.2019

Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Auteurs: Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad-Santos
Publié dans: Journal of Pharmaceutical and Biomedical Analysis, Numéro 151, 2018, Page(s) 116-125, ISSN 0731-7085
Éditeur: Elsevier BV
DOI: 10.1016/j.jpba.2017.12.049

Safety and cardiovascular effects of multiple‐dose administration of aripiprazole and olanzapine in a randomised clinical trial

Auteurs: Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Aneta Wojnicz, Samuel Martín, Daniel Romero‐Palacián, Marcos Navares‐Gómez, Francisco Abad‐Santos
Publié dans: Human Psychopharmacology: Clinical and Experimental, Numéro 36/1, 2021, Page(s) 1-12, ISSN 0885-6222
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hup.2761

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

Auteurs: Florian Hinte, Eelco van Anken, Boaz Tirosh, Wolfram Brune
Publié dans: eLife, Numéro 9, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.51804

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Auteurs: Saiz-Rodríguez, Miriam; Ochoa, Dolores; Belmonte, Carmen; Román, Manuel; Vieira de Lara, Danilo; Zubiaur, Pablo; Koller, Dora; Mejía, Gina; Abad-Santos, Francisco
Publié dans: Journal of Psychopharmacology 33(4): 522-531 (2019), Numéro 1, 2019, ISSN 0269-8811
Éditeur: SAGE Publications

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

Auteurs: Águeda González-Rodríguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, Inés Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, María J. Moreno-Aliaga, Carmelo García-Monzón, Aránzazu Sánchez, Ángela M. Valverde
Publié dans: Molecular Metabolism, Numéro 7, 2018, Page(s) 132-146, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.10.008

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Auteurs: Patricia Rada, Virginia Pardo, Maysa A. Mobasher, Irma García-Martínez, Laura Ruiz, Águeda González-Rodríguez, Cristina Sanchez-Ramos, Jordi Muntané, Susana Alemany, Laura P. James, Kenneth J. Simpson, María Monsalve, Maria Pilar Valdecantos, Ángela M. Valverde
Publié dans: Antioxidants & Redox Signaling, Numéro 28/13, 2018, Page(s) 1187-1208, ISSN 1523-0864
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7373

IGF-1, Inflammation and Retinal Degeneration: A Close Network

Auteurs: Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ángela M. Valverde
Publié dans: Frontiers in Aging Neuroscience, Numéro 10, 2018, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00203

Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney

Auteurs: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani
Publié dans: Nutrients, Numéro 10/6, 2018, Page(s) 689, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10060689

Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure

Auteurs: Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
Publié dans: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.1067

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants

Auteurs: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 123/4, 2018, Page(s) 474-485, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13031

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B

Auteurs: Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde, Lisardo Boscá
Publié dans: Redox Biology, Numéro 17, 2018, Page(s) 213-223, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2018.04.018

The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants

Auteurs: Elena Alcalde-Estévez, Ana I. Arroba, Elena M. Sánchez-Fernández, Carmen Ortiz Mellet, Jose M. García Fernández, Laura Masgrau, Ángela M. Valverde
Publié dans: Food and Chemical Toxicology, Numéro 111, 2018, Page(s) 454-466, ISSN 0278-6915
Éditeur: Elsevier BV
DOI: 10.1016/j.fct.2017.11.050

Medical and Dietary Uses of N-Acetylcysteine

Auteurs: Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Publié dans: Antioxidants, Numéro 8/5, 2019, Page(s) 111, ISSN 2076-3921
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antiox8050111

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

Auteurs: Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde
Publié dans: Redox Biology, Numéro 26, 2019, Page(s) 101263, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2019.101263

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Auteurs: Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Publié dans: Disease Models & Mechanisms, Numéro 12/7, 2019, Page(s) dmm038810, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.038810

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Auteurs: M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo García-Monzón, Borja Lanzón, Javier Rupérez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ángela M. Valverde
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-33949-z

Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?

Auteurs: Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00457

Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy

Auteurs: Alessandra Stacchiotti, Ilaria Grossi, Raquel García-Gómez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani
Publié dans: Cells, Numéro 8/9, 2019, Page(s) 1053, ISSN 2073-4409
Éditeur: Cells
DOI: 10.3390/cells8091053

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

Auteurs: Salvador Pérez, Sergio Rius‐Pérez, Isabela Finamor, Pablo Martí‐Andrés, Ignacio Prieto, Raquel García, María Monsalve, Juan Sastre
Publié dans: The Journal of Pathology, 2018, ISSN 0022-3417
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/path.5166

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects

Auteurs: Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos
Publié dans: Journal of Psychopharmacology, Numéro 32/11, 2018, Page(s) 1212-1222, ISSN 0269-8811
Éditeur: SAGE Publications
DOI: 10.1177/0269881118798605

Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

Auteurs: Assel Sarsenbayeva, Cátia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira
Publié dans: Psychoneuroendocrinology, 2019, Page(s) 104445, ISSN 0306-4530
Éditeur: Pergamon Press
DOI: 10.1016/j.psyneuen.2019.104445

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Auteurs: Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Publié dans: Archives of Medical Science, Numéro 15/5, 2019, Page(s) 1184-1194, ISSN 1734-1922
Éditeur: Termedia
DOI: 10.5114/aoms.2019.87462

Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival

Auteurs: Izak Patrik Miller, Ivan Pavlović, Borut Poljšak, Dušan Šuput, Irina Milisav
Publié dans: Antioxidants, Numéro 8/10, 2019, Page(s) 434, ISSN 2076-3921
Éditeur: Antioxidants
DOI: 10.3390/antiox8100434

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

Auteurs: Diana Grajales, Vitor Ferreira, Ángela M. Valverde
Publié dans: Cells, Numéro 8/11, 2019, Page(s) 1336, ISSN 2073-4409
Éditeur: Cells
DOI: 10.3390/cells8111336

Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

Auteurs: Vitor Ferreira, Diana Grajales, Ángela M. Valverde
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Numéro 1865/2, 2020, Page(s) 158534, ISSN 1388-1981
Éditeur: Elsevier BV
DOI: 10.1016/j.bbalip.2019.158534

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts

Auteurs: Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, María Monsalve
Publié dans: Free Radical Biology and Medicine, Numéro 138, 2019, Page(s) 23-32, ISSN 0891-5849
Éditeur: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2019.04.015

Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

Auteurs: Ignacio Prieto, Carmen Rubio Alarcón, Raquel García-Gómez, Rebeca Berdún, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, M. Begoña Ruiz-Larrea, Mariona Jove, Sebastián Cerdán, María Monsalve
Publié dans: Redox Biology, Numéro 29, 2020, Page(s) 101396, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2019.101396

Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation

Auteurs: Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz
Publié dans: Talanta, Numéro 198, 2019, Page(s) 159-168, ISSN 0039-9140
Éditeur: Elsevier BV
DOI: 10.1016/j.talanta.2019.01.112

The integrated stress response promotes B7H6 expression

Auteurs: Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer Bolsée, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
Publié dans: Journal of Molecular Medicine, Numéro 98/1, 2020, Page(s) 135-148, ISSN 0946-2716
Éditeur: Springer Verlag
DOI: 10.1007/s00109-019-01859-w

Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

Auteurs: Mohamed Mahameed, Shatha Boukeileh, Akram Obiedat, Odai Darawshi, Priya Dipta, Amit Rimon, Gordon McLennan, Rosi Fassler, Dana Reichmann, Rotem Karni, Christian Preisinger, Thomas Wilhelm, Michael Huber, Boaz Tirosh
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-15067-5

The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells

Auteurs: Letícia Selinger Galant, Jamal Rafique, Antônio Luiz Braga, Felipe Camargo Braga, Sumbal Saba, Rafael Radi, João Batista Teixeira da Rocha, Claudio Santi, Maria Monsalve, Marcelo Farina, Andreza Fabro de Bem
Publié dans: Neurochemical Research, 2020, ISSN 0364-3190
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-020-03026-x

Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells

Auteurs: Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh
Publié dans: Journal of Pharmacology and Experimental Therapeutics, 2020, ISSN 1521-0103
Éditeur: ASPET
DOI: 10.1124/jpet.119.264481

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Auteurs: Rubio, Carmen; Puerto, Marta; García-Rodríquez, Juan J; Lu, Van B; García-Martínez, Irma; Alén, Rosa; Sanmartín-Salinas, Patricia; Toledo-Lobo, M Val; Saiz, Jorge; Ruperez, Javier; Barbas, Coral; Menchén, Luis; Gribble, Fiona; Reimann, Frank; Guijarro, Luis G; Carrascosa, Jose M; Valverde, Ángela M
Publié dans: Molecular Metabolism, Numéro 29, 2020, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.17863/cam.48676

Evaluation of Voriconazole CYP2C19 Phenotype-Guided Dose Adjustments by Physiologically Based Pharmacokinetic Modeling

Auteurs: Pablo Zubiaur, Lisa A. Kneller, Dolores Ochoa, Gina Mejía, Miriam Saiz-Rodríguez, Alberto M. Borobia, Dora Koller, Irene García García, Marcos Navares-Gómez, Georg Hempel, Francisco Abad-Santos
Publié dans: Clinical Pharmacokinetics, Numéro 60/2, 2021, Page(s) 261-270, ISSN 0312-5963
Éditeur: Adis International Ltd.
DOI: 10.1007/s40262-020-00941-8

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics

Auteurs: Miriam Saiz-Rodríguez, Dolores Ochoa, Carmen Belmonte, Manuel Román, Danilo Vieira de Lara, Pablo Zubiaur, Dora Koller, Gina Mejía, Francisco Abad-Santos
Publié dans: Journal of Psychopharmacology, Numéro 33/4, 2019, Page(s) 522-531, ISSN 0269-8811
Éditeur: SAGE Publications
DOI: 10.1177/0269881119827959

The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple‐dose trial

Auteurs: Dora Koller, Miriam Saiz‐Rodríguez, Pablo Zubiaur, Dolores Ochoa, Susana Almenara, Manuel Román, Daniel Romero‐Palacián, Alejandro Miguel‐Cáceres, Samuel Martín, Marcos Navares‐Gómez, Gina Mejía, Aneta Wojnicz, Francisco Abad‐Santos
Publié dans: British Journal of Clinical Pharmacology, Numéro 86/10, 2020, Page(s) 2051-2062, ISSN 0306-5251
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bcp.14300

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers

Auteurs: Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Dora Koller, María Talegón, María C. Ovejero-Benito, Rosario López-Rodríguez, Teresa Cabaleiro, Francisco Abad-Santos
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 122/5, 2018, Page(s) 501-511, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12938

Methodological Approach for the Evaluation of FOXO as a Positive Regulator of Antioxidant Genes

Auteurs: María Monsalve, Ignacio Prieto, Andreza Fabro de Bem, Yolanda Olmos
Publié dans: FOXO Transcription Factors - Methods and Protocols, Numéro 1890, 2019, Page(s) 61-76, ISBN 978-1-4939-8899-0
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-8900-3_6

Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis.

Auteurs: M.C. Ovejero-Benito, P. Sánchez-Jiménez, M. Saiz-Rodríguez, S. Martín-Vilchez, T. Cabaleiro, M. Román, D. Ochoa, F. Abad-Santos, A. Reolid, E. Muñoz-Aceituno, M. Llamas-Velasco, E. Daudén, F. Abad-Santos
Publié dans: IBJ Plus, 2018, ISSN 2531-0151
Éditeur: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00007

Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations.

Auteurs: Catía Marques, Assel Sarsenbayeva, Gretha Boersma, Maria João Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, Eugénia Carvalho
Publié dans: IBJ Plus, 2018, ISSN 2531-0151
Éditeur: IberoAmerican Journals
DOI: 10.24217/2531-0151.18v1s1.00008

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