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Imaging and detection of tumor-associated glycan structures on tumor cells

Projektbeschreibung

Glykan-spezifische Sonden zum Nachweis von Krebsfrühformen

Die Krebsentwicklung ist ein mehrstufiger Prozess, und den Tumor in einem frühen Stadium zu entdecken, in dem der Krebs noch heilbar ist, erfordert empfindliche und wirksame Diagnoseinstrumente. Das im Rahmen der Marie-Skłodowska-Curie-Maßnahmen finanzierte Projekt GlycoImaging zielt darauf ab, neue Assays für den Nachweis von Glykanen als Biomarker für aggressive metastasierende Krebsarten in Blut, Urin, Zellen und Gewebe zu entwickeln und zu implementieren. Das Projekt umfasst die Schulung von 8 Fachleuten für die Frühphasenforschung durch ein Konsortium aus 6 Partnern aus dem akademischen Bereich und der Industrie mit Kompetenzen in den Bereichen Biomedizin, Bildgebung und Partikelsynthese. Ziel des Projekts ist es, die Grundlage für ein hochwertiges interdisziplinäres Schulungs- und Forschungsausbildungsprogramm zu schaffen.

Ziel

The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns.
The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research.

8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

Koordinator

MALMO UNIVERSITET
Netto-EU-Beitrag
€ 263 659,32
Adresse
NORDENSKIOLDSGATAN 1
205 06 Malmoe
Schweden

Auf der Karte ansehen

Region
Södra Sverige Sydsverige Skåne län
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 263 659,32

Beteiligte (5)