Tribbles Research and Innovation Network

Project Information

TRAIN

Grant agreement ID: 721532

DOI

10.3030/721532

Project closed

EC signature date 29 August 2016

Start date 1 September 2016

End date 30 November 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 818 969,68

EU contribution

€ 3 818 969,68

Coordinated by

THE UNIVERSITY OF SHEFFIELD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (12)

8.1

Signing of Consortium Agreement

3.3

Two conference reports on the mechanisms of TRIB-mediated control of AT accrual and function

2.3

Four manuscripts or conference presentations on AT resident immune cells

5.2

Conference abstracts on regulatory ubiquitination and sumoylation of TRIB3 on the control of PI3K/Akt

8.3

ESR advertisements, recruitment

6.3

Manuscript or conference report on the action of TRIB mRNA destabilising miRNAs

4.3

Three manuscripts and/or conference reports on effects of cell-type spec. Trib-/- activity on prostate tumourigenesis

5.5

Manuscript/conference abstract on the TRIB-mediated, cell-specific control of transcription factor turnover

7.3

Press releases

8.7

Final Report

3.4

Two manuscripts focussing on TRIB-dependent changes in VAT and periprostatic AT

6.5

Conference abstract on the functional consequences of E3 inhibition in prostate cancer cells

Websites, patent fillings, videos etc. (3)

8.2

Kick-off Meeting

7.2

Consortium Conference

7.1

Setup of website and presence in Social Media

Other (1)

7.4

Coordination of Outreach

Publications

Peer reviewed articles (12)

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Author(s): Marta Palomo-Irigoyen, Encarni Pérez-Andrés, Marta Iruarrizaga-Lejarreta, Adrián Barreira-Manrique, Miguel Tamayo-Caro, Laura Vila-Vecilla, Leire Moreno-Cugnon, Nagore Beitia, Daniela Medrano, David Fernández-Ramos, Juan José Lozano, Satoshi Okawa, José L. Lavín, Natalia Martín-Martín, James D. Sutherland, Virginia Guitiérez de Juan, Monika Gonzalez-Lopez, Nuria Macías-Cámara, David Mo
Published in: Journal of Clinical Investigation, Issue 130/7, 2020, Page(s) 3848-3864, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci130379

Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer

Author(s): Lorea Valcarcel-Jimenez, Alice Macchia, Natalia Martín-Martín, Ana Rosa Cortazar, Ariane Schaub-Clerigué, Mikel Pujana-Vaquerizo, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Aida Santos-Martin, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Ivana Hermanova, Ianire Astobiza, Mariona Graupera, Julia Starkova, James Sutherland, Rosa Barrio, Ana M. Aransay, Arkaitz Carracedo, Verónica Torrano
Published in: Cell Death & Disease, Issue 9/10, 2018, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-018-1096-6

Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment

Author(s): Robert J. van Eijkeren, Imogen Morris, Anouska Borgman, Angela Markovska, Eric Kalkhoven
Published in: Frontiers in Endocrinology, Issue 11, 2020, ISSN 1664-2392
Publisher: Frontiers in Endochrinology
DOI: 10.3389/fendo.2020.00479

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

Author(s): Ingrid Gomez, Ben Ward, Celine Souilhol, Chiara Recarti, Mark Ariaans, Jessica Johnston, Amanda Burnett, Marwa Mahmoud, Le Anh Luong, Laura West, Merete Long, Sion Parry, Rachel Woods, Carl Hulston, Birke Benedikter, Chiara Niespolo, Rohit Bazaz, Sheila Francis, Endre Kiss-Toth, Marc van Zandvoort, Andreas Schober, Paul Hellewell, Paul C. Evans, Victoria Ridger
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14043-y

Tribbles-1 expression and its function to control inflammatory cytokines, including Interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells

Author(s): Chiara Niespolo, Jessica M Johnston, Sumeet R Deshmukh, Swapna Satam, Ziyanda Shologu, TRAIN Consortium, Oscar Villacanas, Ian M Subery, Heather L Wilson, Endre Kiss-Toth
Published in: Frontiers in Immunology, 2020, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2020.574046

Long Non-Coding RNAs in Metabolic Organs and Energy Homeostasis

Author(s): Maude Giroud, Marcel Scheideler
Published in: International Journal of Molecular Sciences, Issue 18/12, 2017, Page(s) 2578, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18122578

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Author(s): Parastoo Shahrouzi, Ianire Astobiza, Ana R. Cortazar, Verónica Torrano, Alice Macchia, Juana M. Flores, Chiara Niespolo, Isabel Mendizabal, Ruben Caloto, Amaia Ercilla, Laura Camacho, Leire Arreal, Maider Bizkarguenaga, Maria L. Martinez-Chantar, Xose R. Bustelo, Edurne Berra, Endre Kiss-Toth, Guillermo Velasco, Amaia Zabala-Letona, Arkaitz Carracedo
Published in: Cancers, Issue 12/9, 2020, Page(s) 2593, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092593

Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not

Author(s): Jack L Williams, Anju Paudyal, Sherine Awad, James Nicholson, Dominika Grzesik, Joaquin Botta, Eirini Meimaridou, Avinaash V Maharaj, Michelle Stewart, Andrew Tinker, Roger D Cox, Lou A Metherell
Published in: Life Science Alliance, Issue 3/4, 2020, Page(s) e201900593, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.201900593

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Author(s): Javier Plou, Isabel García, Mathias Charconnet, Ianire Astobiza, Clara García‐Astrain, Cristiano Matricardi, Agustín Mihi, Arkaitz Carracedo, Luis M. Liz‐Marzán
Published in: Advanced Functional Materials, Issue 30/17, 2020, Page(s) 1910335, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201910335

Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling

Author(s): Jack P Green, Celine Souilhol, Ioannis Xanthis, Laura Martinez-Campesino, Neil P Bowden, Paul C Evans, Heather L Wilson
Published in: Cardiovascular Research, Issue 114/2, 2017, Page(s) 324-335, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvx213

Experimental models of murine atherosclerosis: does perception match reality?

Author(s): Jessica M Johnston, Sheila E Francis, Endre Kiss-Toth
Published in: Cardiovascular Research, 2018, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy140

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

Author(s): Jose Miguel Ramos Pittol, Alexandra Milona, Imogen Morris, Ellen C.L. Willemsen, Suzanne W. van der Veen, Eric Kalkhoven, Saskia W.C. van Mil
Published in: Gastroenterology, Issue 159/5, 2020, Page(s) 1853-1865.e10, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.07.036

Non-peer reviewed articles (1)

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

Author(s): Cui, Bing Eyers, Patrick A. Dobens, Leonard L. Tan, Nguan Soon Mace, Peter D. Link, Wolfgang A. Kiss-Toth, Endre Keeshan, Karen Nakamura, Takuro Pear, Warren S. Feseha, Yodit Johnston, Jessica Carracedo, Arkatiz Scheideler, Marcel llyas, Zabra Bauer, Robert C. Erusalimsky, Jorge
Published in: Acta Pharmaceutica Sinica B, Issue 9/2, 2019, Page(s) 443-454, ISSN 2211-3835
Publisher: Elsevier BV
DOI: 10.1016/j.apsb.2018.12.007

Conference proceedings (2)

Post-transcriptional regulation of trib1 by mirnas in primary macrophages

Author(s): Chiara Niespolo, Juan Salamanca Viloria, Oscar Villacanas Perez, Heather Wilson, Endre Kiss-Toth
Published in: Heart, Issue Volume 104, Issue Supp 6, 2018
Publisher: BMJ Journals
DOI: 10.1136/heartjnl-2018-BCS.109

TRIB3-mediated regulationof macrophage phenotype

Author(s): Laura Martinez Campesino, Jessica Johnston, Endre Kiss-Toth, Heather Wilson
Published in: Heart, Issue Vol 104, Issue Suppl 6, 2018
Publisher: BMJ Publishing Group Limited
DOI: 10.1136/heartjnl-2018-BCS.113

Other (1)

FaDA: A Shiny web application to accelerate common lab data analyses

Author(s): Yodit Feseha; Quentin Moiteaux; Estelle Geffard; Gérard Ramstein; Sophie Brouard; Richard Danger
Published in: BioRxiv, Issue 5, 2020
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/2020.04.23.055673