Tribbles Research and Innovation Network

Risultati finali

8.1

Signing of Consortium Agreement

3.3

Two conference reports on the mechanisms of TRIB-mediated control of AT accrual and function

2.3

Four manuscripts or conference presentations on AT resident immune cells

5.2

Conference abstracts on regulatory ubiquitination and sumoylation of TRIB3 on the control of PI3K/Akt

8.3

ESR advertisements, recruitment

6.3

Manuscript or conference report on the action of TRIB mRNA destabilising miRNAs

4.3

Three manuscripts and/or conference reports on effects of cell-type spec. Trib-/- activity on prostate tumourigenesis

5.5

Manuscript/conference abstract on the TRIB-mediated, cell-specific control of transcription factor turnover

7.3

Press releases

8.7

Final Report

3.4

Two manuscripts focussing on TRIB-dependent changes in VAT and periprostatic AT

6.5

Conference abstract on the functional consequences of E3 inhibition in prostate cancer cells

8.2

Kick-off Meeting

7.2

Consortium Conference

7.1

Setup of website and presence in Social Media

7.4

Coordination of Outreach

Pubblicazioni

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Autori: Marta Palomo-Irigoyen, Encarni Pérez-Andrés, Marta Iruarrizaga-Lejarreta, Adrián Barreira-Manrique, Miguel Tamayo-Caro, Laura Vila-Vecilla, Leire Moreno-Cugnon, Nagore Beitia, Daniela Medrano, David Fernández-Ramos, Juan José Lozano, Satoshi Okawa, José L. Lavín, Natalia Martín-Martín, James D. Sutherland, Virginia Guitiérez de Juan, Monika Gonzalez-Lopez, Nuria Macías-Cámara, David Mo
Pubblicato in: Journal of Clinical Investigation, Numero 130/7, 2020, Pagina/e 3848-3864, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci130379

Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer

Autori: Lorea Valcarcel-Jimenez, Alice Macchia, Natalia Martín-Martín, Ana Rosa Cortazar, Ariane Schaub-Clerigué, Mikel Pujana-Vaquerizo, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Aida Santos-Martin, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Ivana Hermanova, Ianire Astobiza, Mariona Graupera, Julia Starkova, James Sutherland, Rosa Barrio, Ana M. Aransay, Arkaitz Carracedo, Verónica Torrano
Pubblicato in: Cell Death & Disease, Numero 9/10, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-1096-6

Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment

Autori: Robert J. van Eijkeren, Imogen Morris, Anouska Borgman, Angela Markovska, Eric Kalkhoven
Pubblicato in: Frontiers in Endocrinology, Numero 11, 2020, ISSN 1664-2392
Editore: Frontiers in Endochrinology
DOI: 10.3389/fendo.2020.00479

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

Autori: Ingrid Gomez, Ben Ward, Celine Souilhol, Chiara Recarti, Mark Ariaans, Jessica Johnston, Amanda Burnett, Marwa Mahmoud, Le Anh Luong, Laura West, Merete Long, Sion Parry, Rachel Woods, Carl Hulston, Birke Benedikter, Chiara Niespolo, Rohit Bazaz, Sheila Francis, Endre Kiss-Toth, Marc van Zandvoort, Andreas Schober, Paul Hellewell, Paul C. Evans, Victoria Ridger
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-14043-y

Tribbles-1 expression and its function to control inflammatory cytokines, including Interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells

Autori: Chiara Niespolo, Jessica M Johnston, Sumeet R Deshmukh, Swapna Satam, Ziyanda Shologu, TRAIN Consortium, Oscar Villacanas, Ian M Subery, Heather L Wilson, Endre Kiss-Toth
Pubblicato in: Frontiers in Immunology, 2020, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2020.574046

Long Non-Coding RNAs in Metabolic Organs and Energy Homeostasis

Autori: Maude Giroud, Marcel Scheideler
Pubblicato in: International Journal of Molecular Sciences, Numero 18/12, 2017, Pagina/e 2578, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18122578

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Autori: Parastoo Shahrouzi, Ianire Astobiza, Ana R. Cortazar, Verónica Torrano, Alice Macchia, Juana M. Flores, Chiara Niespolo, Isabel Mendizabal, Ruben Caloto, Amaia Ercilla, Laura Camacho, Leire Arreal, Maider Bizkarguenaga, Maria L. Martinez-Chantar, Xose R. Bustelo, Edurne Berra, Endre Kiss-Toth, Guillermo Velasco, Amaia Zabala-Letona, Arkaitz Carracedo
Pubblicato in: Cancers, Numero 12/9, 2020, Pagina/e 2593, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092593

Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not

Autori: Jack L Williams, Anju Paudyal, Sherine Awad, James Nicholson, Dominika Grzesik, Joaquin Botta, Eirini Meimaridou, Avinaash V Maharaj, Michelle Stewart, Andrew Tinker, Roger D Cox, Lou A Metherell
Pubblicato in: Life Science Alliance, Numero 3/4, 2020, Pagina/e e201900593, ISSN 2575-1077
Editore: Life Science Alliance LLC
DOI: 10.26508/lsa.201900593

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Autori: Javier Plou, Isabel García, Mathias Charconnet, Ianire Astobiza, Clara García‐Astrain, Cristiano Matricardi, Agustín Mihi, Arkaitz Carracedo, Luis M. Liz‐Marzán
Pubblicato in: Advanced Functional Materials, Numero 30/17, 2020, Pagina/e 1910335, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201910335

Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling

Autori: Jack P Green, Celine Souilhol, Ioannis Xanthis, Laura Martinez-Campesino, Neil P Bowden, Paul C Evans, Heather L Wilson
Pubblicato in: Cardiovascular Research, Numero 114/2, 2017, Pagina/e 324-335, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx213

Experimental models of murine atherosclerosis: does perception match reality?

Autori: Jessica M Johnston, Sheila E Francis, Endre Kiss-Toth
Pubblicato in: Cardiovascular Research, 2018, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy140

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

Autori: Jose Miguel Ramos Pittol, Alexandra Milona, Imogen Morris, Ellen C.L. Willemsen, Suzanne W. van der Veen, Eric Kalkhoven, Saskia W.C. van Mil
Pubblicato in: Gastroenterology, Numero 159/5, 2020, Pagina/e 1853-1865.e10, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.07.036

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

Autori: Cui, Bing Eyers, Patrick A. Dobens, Leonard L. Tan, Nguan Soon Mace, Peter D. Link, Wolfgang A. Kiss-Toth, Endre Keeshan, Karen Nakamura, Takuro Pear, Warren S. Feseha, Yodit Johnston, Jessica Carracedo, Arkatiz Scheideler, Marcel llyas, Zabra Bauer, Robert C. Erusalimsky, Jorge
Pubblicato in: Acta Pharmaceutica Sinica B, Numero 9/2, 2019, Pagina/e 443-454, ISSN 2211-3835
Editore: Elsevier BV
DOI: 10.1016/j.apsb.2018.12.007

Post-transcriptional regulation of trib1 by mirnas in primary macrophages

Autori: Chiara Niespolo, Juan Salamanca Viloria, Oscar Villacanas Perez, Heather Wilson, Endre Kiss-Toth
Pubblicato in: Heart, Numero Volume 104, Numero Supp 6, 2018
Editore: BMJ Journals
DOI: 10.1136/heartjnl-2018-BCS.109

TRIB3-mediated regulationof macrophage phenotype

Autori: Laura Martinez Campesino, Jessica Johnston, Endre Kiss-Toth, Heather Wilson
Pubblicato in: Heart, Numero Vol 104, Numero Suppl 6, 2018
Editore: BMJ Publishing Group Limited
DOI: 10.1136/heartjnl-2018-BCS.113

FaDA: A Shiny web application to accelerate common lab data analyses

Autori: Yodit Feseha; Quentin Moiteaux; Estelle Geffard; Gérard Ramstein; Sophie Brouard; Richard Danger
Pubblicato in: BioRxiv, Numero 5, 2020
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/2020.04.23.055673

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