Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Report on Congress presentations and Scientific Publications II

Report on Congress presentations and Scientific Publications

PhDs

Report on already awarded PhDs

Application of image processing and analysis methods to ImageInLife data
New protocols to image the developing vertebrate embryos to the subcellular level
Ultrastructural data correlated to fluorescence images

Ultrastructural data correlated to fluorescence images: Correlate confocal and electron microscopy data

Tissue geometry & physics

Tissue geometry & physics : cell-cell interactions, subcellular elements, extracellular matrix Generic models with simulation/visualisation software, customised to zebrafish or mammalian datasets

Dissemination of knowledge

Draft (midterm) and final version (final report) of the plan for the use and dissemination of knowledge

Search & optimisation

Parameter search & optimisation: comparison between simulations & data

Design of image processing and analysis methods
Final report

Final report to the commission

Virus propagation

Virus propagation model: immune status, cell response, pathways of virus dissemination

Report on Congress Presentations and Scientific Publications I

Report on Congress Presentations and Scientific Publications

in vivo tracers, reporters & actuators

in vivo tracers, reporters & actuators: validation of staining strategies for signalling pathways and gene expression patterns

Consortium agreement
Outreach activities

Record of all participants’ contributions to outreach activities targeted at schools and at the general public

Midterm report

Midterm report to the commission. The due date is indicative. This deliverable must be submitted at least one month before the Midterm review meeting.

Cell biomechanics

Models of Cell biomechanics : cell types, shapes & behaviours,

Computer implementation of image processing and analysis methods
Infection protocols

Infection protocols for high throughput imaging of infected zebrafish embryo

Genetic/molecular control

Models of Genetic/molecular control : gene regulation network, chemical signalling, interface with BioTapestry, reverse engineering of circuits from atlases

Data Management Plan

Frist version of the Data Management Plan

Final version of the Data Management Plan

Brochure, Website & Advertising

ImageInLife Brochure, website & vacancies advertising

MOOCs

Online dissemination using MOOCs

Wikipedia article
Video series

Video series for outreaches activities

Multimodal and multiscale LSFM workstation

Multimodal and multiscale LSFM workstation, software and image analysis

Incubation chambers

Incubation chambers for multilevel imaging of embryos, mammals and zebrafish, normal and infected, at different imaging resolutions

Image acquisition systems for infected embryos

Image acquisition systems for infected embryos using the VAST-BioImager

Super-resolution-LSFM for imaging of cellular processes within the embryo

Implementation of strategies for Super-resolution-LSFM for imaging of cellular processes within the embryo

Pubblicazioni

Exploring zebrafish larvae as a COVID-19 model: probable SARS-COV-2 replication in the swim bladder

Autori: Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Pierre Boudinot, Irene Salinas, Georges Lutfalla, Marco Vignuzzi, Jean-Pierre Levraud
Pubblicato in: BioRxiv, 2021
Editore: bioRxiv
DOI: 10.1101/2021.04.08.439059

A contractile acto-myosin belt promotes growth anisotropy during the early stages of pectoral fin development in zebrafish.

Autori: Elena Kardash, Hanh Nguyen, Martin Behrndt, Carl-Philipp Heisenberg, Nadine Peyrieras, Marcos Gonzalez-Gaitan
Pubblicato in: Biorxiv, 2019
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/512038

Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation

Autori: Joel Dokmegang, Moi Hoon Yap, Liangxiu Han, Matteo Cavaliere, René Doursat
Pubblicato in: PLOS ONE, Numero 16/7, 2021, Pagina/e e0254763, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0254763

Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates

Autori: Mai Nguyen‐Chi, Patricia Luz‐Crawford, Laurence Balas, Tamara Sipka, Rafael Contreras‐López, Audrey Barthelaix, Georges Lutfalla, Thierry Durand, Christian Jorgensen, Farida Djouad
Pubblicato in: British Journal of Pharmacology, Numero 177/17, 2020, Pagina/e 4055-4073, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.15156

Quantification of cell behaviors and computational modeling show that cell directional behaviors drive zebrafish pectoral fin morphogenesis

Autori: Joel Dokmegang, Hanh Nguyen, Elena Kardash, Thierry Savy, Matteo Cavaliere, Nadine Peyriéras, René Doursat
Pubblicato in: Bioinformatics, 2021, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btab201

Trophectoderm mechanics direct epiblast shape upon embryo implantation

Autori: Antonia Weberling, Magdalena Zernicka-Goetz
Pubblicato in: Cell Reports, Numero 34/3, 2021, Pagina/e 108655, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108655

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Autori: Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz
Pubblicato in: Cell Reports, Numero 34/10, 2021, Pagina/e 108834, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.108834

Fiji plugins for qualitative image annotations: routine analysis and application to image classification

Autori: Laurent S. V. Thomas, Franz Schaefer, Jochen Gehrig
Pubblicato in: F1000Research, Numero 9, 2020, Pagina/e 1248, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.26872.2

Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection

Autori: Malika Moussouni, Laurence Berry, Tamara Sipka, Mai Nguyen-Chi, Anne-Béatrice Blanc-Potard
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-79678-0

Autophagy and Lc3-Associated Phagocytosis in Zebrafish Models of Bacterial Infections

Autori: Salomé Muñoz-Sánchez, Michiel van der Vaart, Annemarie H. Meijer
Pubblicato in: Cells, Numero 9/11, 2020, Pagina/e 2372, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells9112372

3D Cell Image Segmentation by Modified Subjective Surface Method

Autori: MarKjoe Olunna Uba, Karol Mikula, Zuzana Krivá, Hanh Nguyen, Thierry Savy, Eléna Kardash, Nadine Peyríeras
Pubblicato in: Tatra Mountains Mathematical Publications, Numero 75/1, 2020, Pagina/e 147-162, ISSN 1338-9750
Editore: Tatra Mountains Mathematical Publications
DOI: 10.2478/tmmp-2020-0010

Analysis of intracellular protein dynamics in living zebrafish embryos using light-sheet fluorescence single-molecule microscopy

Autori: Matteo Bernardello, Radoslaw J. Gora, Patrick Van Hage, Gustavo Castro-Olvera, Emilio J. Gualda, Marcel J. M. Schaaf, Pablo Loza-Alvarez
Pubblicato in: Biomedical Optics Express, Numero 12/10, 2021, Pagina/e 6205, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.435103

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

Autori: Laurent Boucontet, Gabriella Passoni, Valéry Thiry, Ludovico Maggi, Philippe Herbomel, Jean-Pierre Levraud, Emma Colucci-Guyon
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01084

Neutrophils use superoxide to control bacterial infection at a distance

Autori: Quang Tien Phan, Tamara Sipka, Catherine Gonzalez, Jean-Pierre Levraud, Georges Lutfalla, Mai Nguyen-Chi
Pubblicato in: PLOS Pathogens, Numero 14/7, 2018, Pagina/e e1007157, ISSN 1553-7374
Editore: PLOS Pathogens
DOI: 10.1371/journal.ppat.1007157

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Autori: Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui, Guangdun Peng, Naihe Jing, Magdalena Zernicka-Goetz
Pubblicato in: Nature Cell Biology, Numero 20/11, 2018, Pagina/e 1278-1289, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-018-0211-3

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Autori: Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11482-5

Macrophage Image Segmentation by Thresholding and Subjective Surface Method

Autori: Seol Ah Park, Tamara Sipka, Zuzana Krivá, Martin Ambroz, Michal Kollár, Balázs Kósa, Mai Nguyen-Chi, Georges Lutfalla, Karol Mikula
Pubblicato in: Tatra Mountains Mathematical Publications, Numero 75/1, 2020, Pagina/e 103-120, ISSN 1338-9750
Editore: Tatra Mountains Mathematical Publications
DOI: 10.2478/tmmp-2020-0007

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

Autori: Ghizlane Maarifi, Nikaïa Smith, Sarah Maillet, Olivier Moncorgé, Célia Chamontin, Joanne Edouard, Frédéric Sohm, Fabien P. Blanchet, Jean-Philippe Herbeuval, Georges Lutfalla, Jean-Pierre Levraud, Nathalie J. Arhel, Sébastien Nisole
Pubblicato in: Science Advances, Numero 5/11, 2019, Pagina/e eaax3511, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax3511

IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity

Autori: Jean-Pierre Levraud, Luc Jouneau, Valérie Briolat, Valerio Laghi, Pierre Boudinot
Pubblicato in: The Journal of Immunology, Numero 203/12, 2019, Pagina/e 3361-3373, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1900804

Multi-template matching: a versatile tool for object-localization in microscopy images

Autori: Laurent S. V. Thomas, Jochen Gehrig
Pubblicato in: BMC Bioinformatics, Numero 21/1, 2020, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-020-3363-7

ImageJ/Fiji ROI 1-click tools for rapid manual image annotations and measurements

Autori: Laurent SV Thomas and Jochen Gehrig
Pubblicato in: microPublication Biology, 2020, ISSN 2578-9430
Editore: microPublication
DOI: 10.17912/micropub.biology.000215

Light-sheet fluorescence microscopy for the in vivo study of microtubule dynamics in the zebrafish embryo

Autori: Matteo Bernardello, Maria Marsal, Emilio J. Gualda, Pablo Loza-Alvarez
Pubblicato in: Biomedical Optics Express, Numero 12/10, 2021, Pagina/e 6237, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.438402

Efficient 3D Shape Registration by Using Distance Maps and Stochastic Gradient Descent Method

Autori: Polycarp Omondi Okock, Jozef Urbán, Karol Mikula
Pubblicato in: Tatra Mountains Mathematical Publications, Numero 75/1, 2020, Pagina/e 81-102, ISSN 1338-9750
Editore: Tatra Mountains Mathematical Publications
DOI: 10.2478/tmmp-2020-0006

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs

Autori: Jens H. Westhoff, Petrus J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Thomas Bruckner, Ledean Cooper, Burkhard Tönshoff, Georg F. Hoffmann, Jochen Gehrig
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 8, 2020, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2020.00583

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Autori: Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.636585

Characterization of a member of the CEACAM protein family as a novel marker of proton pump-rich ionocytes on the zebrafish epidermis

Autori: Julien Kowalewski, Théo Paris, Catherine Gonzalez, Etienne Lelièvre, Lina Castaño Valencia, Morgan Boutrois, Camille Augier, Georges Lutfalla, Laure Yatime
Pubblicato in: PLOS ONE, Numero 16/7, 2021, Pagina/e e0254533, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0254533

3D image segmentation supported by a point cloud

Autori: Balázs Kósa, Karol Mikula, Markjoe Olunna Uba, Antonia Weberling, Neophytos Christodoulou, Magdalena Zernicka-Goetz
Pubblicato in: Discrete & Continuous Dynamical Systems - S, Numero 14/3, 2021, Pagina/e 971-985, ISSN 1937-1179
Editore: AIMS
DOI: 10.3934/dcdss.2020351

Application of Modified Subjective Surface Method to 3D Cell Membrane Image Segmentation

Autori: M. O. Uba, K. Mikula, Z. Kriva, H. Nguyen, T. Savy, E. Kardash, N. Peyrieras
Pubblicato in: ALGORITMY 2020, 2020, Pagina/e 51-60
Editore: Proceedings of the Conference Algoritmy 2020

3D + Time Imaging and Image Reconstruction of Pectoral Fin During Zebrafish Embryogenesis

Autori: Hanh Nguyen, Jaume Boix-Fabrés, Nadine Peyriéras, Elena Kardash
Pubblicato in: Computer Optimized Microscopy - Methods and Protocols, Numero 2040, 2019, Pagina/e 135-153, ISBN 978-1-4939-9685-8
Editore: Springer New York
DOI: 10.1007/978-1-4939-9686-5_8

3D + time imaging of normal and twin sea urchin embryos for the reconstruction of their cell lineage

Autori: Antonio Ortiz, Elena Kardash, Nadine Peyriéras
Pubblicato in: Echinoderms, Part B, Numero 151, 2019, Pagina/e 399-418, ISBN 9780128170724
Editore: Elsevier
DOI: 10.1016/bs.mcb.2019.01.008

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