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Smart capture phases for proteomics, glycomics and biomarker assays

Objective

The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer
and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins. This will be
achieved by exploiting robust glycan, peptide and protein binders in the form of Molecularly Imprinted Polymers (MIPs) or plastic antibodies alongside generic enrichment combined with selected reaction monitoring-based mass spectrometry assays. In addition, sequence specific MIPs for multiple proteotypic peptides will be developed for use as capture phases in array format followed by MS or fluorescence based readout as well as a coupling of both detection techniques. The artificial receptors will be developed by various Molecular Imprinting techniques. The research results will lead to technological advances having a major impact on 1) health care since it will profit from methods for earlier, more reliable diagnosis of diseases, 2) drug discovery allowing a faster target or biomarker identification; and 3) biochemistry research laboratories in resulting in improved protein fractionation tools for revealing low abundant post translational modifications. The training of researchers will be performed by a consortium consisting of in total 15 partners whereof 6 polymer/materials research groups, 5 protein/glycan chemistry/analysis groups, 1 separation technology companies, 2 expert groups on platforms for multiplex analysis and one diagnostic company. This forms the basis for a very exciting interdisciplinary training program. Thus 11 early stage researchers (ESRs) working on specific tasks within five work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

Coordinator

MALMO UNIVERSITET
Net EU contribution
€ 565 695,72
Address
Nordenskioldsgatan 1
205 06 Malmoe
Sweden

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (7)

UNIVERSITY OF STRATHCLYDE
United Kingdom
Net EU contribution
€ 273 287,88
Address
Richmond Street 16
G1 1XQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UMEA UNIVERSITET
Sweden
Net EU contribution
€ 263 659,32
Address
Universitetomradet
901 87 Umea

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Region
Norra Sverige Övre Norrland Västerbottens län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG
Germany
Net EU contribution
€ 330 336,45
Address
Unter Den Eichen 87
12205 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SYDDANSK UNIVERSITET
Denmark
Net EU contribution
€ 328 106,78
Address
Campusvej 55
5230 Odense M

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Region
Danmark Syddanmark Fyn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITETET I OSLO
Norway
Net EU contribution
€ 377 962,84
Address
Problemveien 5-7
0313 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 580 163,76
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LINNEUNIVERSITETET
Sweden
Net EU contribution
€ 263 659,32
Address
Linnaeus University
35195 Vaxjo

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Region
Södra Sverige Småland med öarna Kronobergs län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (6)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 0,00
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MIP TECHNOLOGIES AB
Sweden
Net EU contribution
€ 0,00
Address
Research Park Ideon
22370 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 0,00
Address
Oxford Road
M13 9PL Manchester

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ReSyn Biosciences
South Africa
Net EU contribution
€ 0,00
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Net EU contribution
€ 0,00
Address
Strada Nuova 65
27100 Pavia

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Region
Nord-Ovest Lombardia Pavia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

GREIBROKK & TRONES SEPTECH AS *G&T SEPTECH GTS
Norway
Net EU contribution
€ 0,00
Address
Trollasveien 34
1414 Trollasen

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Region
Norge Oslo og Viken Viken
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00