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Smart capture phases for proteomics, glycomics and biomarker assays

Objective

The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer
and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins. This will be
achieved by exploiting robust glycan, peptide and protein binders in the form of Molecularly Imprinted Polymers (MIPs) or plastic antibodies alongside generic enrichment combined with selected reaction monitoring-based mass spectrometry assays. In addition, sequence specific MIPs for multiple proteotypic peptides will be developed for use as capture phases in array format followed by MS or fluorescence based readout as well as a coupling of both detection techniques. The artificial receptors will be developed by various Molecular Imprinting techniques. The research results will lead to technological advances having a major impact on 1) health care since it will profit from methods for earlier, more reliable diagnosis of diseases, 2) drug discovery allowing a faster target or biomarker identification; and 3) biochemistry research laboratories in resulting in improved protein fractionation tools for revealing low abundant post translational modifications. The training of researchers will be performed by a consortium consisting of in total 15 partners whereof 6 polymer/materials research groups, 5 protein/glycan chemistry/analysis groups, 1 separation technology companies, 2 expert groups on platforms for multiplex analysis and one diagnostic company. This forms the basis for a very exciting interdisciplinary training program. Thus 11 early stage researchers (ESRs) working on specific tasks within five work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Coordinator

MALMO UNIVERSITET
Address
Nordenskioldsgatan 1
205 06 Malmoe
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 565 695,72

Participants (7)

UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 273 287,88
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments
UMEA UNIVERSITET
Sweden
EU contribution
€ 263 659,32
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG
Germany
EU contribution
€ 330 336,45
Address
Unter Den Eichen 87
12205 Berlin
Activity type
Research Organisations
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 328 106,78
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norway
EU contribution
€ 377 962,84
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 580 163,76
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
LINNEUNIVERSITETET
Sweden
EU contribution
€ 263 659,32
Address
Linnaeus University
35195 Vaxjo
Activity type
Higher or Secondary Education Establishments

Partners (6)

LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
MIP TECHNOLOGIES AB
Sweden
Address
Research Park Ideon
22370 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
ReSyn Biosciences
South Africa
Address

Edenvale
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
GREIBROKK & TRONES SEPTECH AS *G&T SEPTECH GTS
Norway
Address
Trollasveien 34
1414 Trollasen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)