Programmable Readers, Writers, and Erasers of the Epigenetic Cytosine Code

Project Information

EPICODE

Grant agreement ID: 723863

DOI

10.3030/723863

Project closed

EC signature date 22 April 2017

Start date 1 November 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 979 679,00

EU contribution

€ 1 979 679,00

Coordinated by

TECHNISCHE UNIVERSITAT DORTMUND
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Encoded, click-reactive DNA-binding domains for programmable capture of specific chromatin segments.

Author(s): Anna Witte; Álvaro Muñoz-López; Malte Metz; Michal R. Schweiger; Petra Janning; Daniel Summerer
Published in: Chemical Science, Issue 1, 2020, Page(s) 12506-12511, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc02707c

Epigenetic chromatin modification by amber suppression technology

Author(s): Heinz Neumann, Petra Neumann-Staubitz, Anna Witte, Daniel Summerer
Published in: Current Opinion in Chemical Biology, Issue 45, 2018, Page(s) 1-9, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2018.01.017

Overcoming conservation in TALE–DNA interactions: a minimal repeat scaffold enables selective recognition of an oxidized 5-methylcytosine

Author(s): Sara Maurer, Benjamin Buchmuller, Christiane Ehrt, Julia Jasper, Oliver Koch, Daniel Summerer
Published in: Chemical Science, Issue 9/36, 2018, Page(s) 7247-7252, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc01958d

Expanding the Genetic Code for Site-Directed Spin-Labeling

Author(s): Theresa Braun, Malte Drescher, Daniel Summerer
Published in: International Journal of Molecular Sciences, Issue 20/2, 2019, Page(s) 373, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20020373

Programmable Protein–DNA Cross-Linking for the Direct Capture and Quantification of 5-Formylcytosine

Author(s): Mario Gieß, Álvaro Muñoz-López, Benjamin Buchmuller, Grzegorz Kubik, Daniel Summerer
Published in: Journal of the American Chemical Society, Issue 141/24, 2019, Page(s) 9453-9457, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b01432

Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States

Author(s): Benjamin C. Buchmuller, Brinja Kosel, Daniel Summerer
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-61030-1

Designer Receptors for Nucleotide‐Resolution Analysis of Genomic 5‐Methylcytosine by Cellular Imaging

Author(s): Álvaro Muñoz‐López, Benjamin Buchmuller, Jan Wolffgramm, Anne Jung, Michelle Hussong, Julian Kanne, Michal R. Schweiger, Daniel Summerer
Published in: Angewandte Chemie International Edition, Issue 59/23, 2020, Page(s) 8927-8931, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202001935

Light-Activatable TET-Dioxygenases Reveal Dynamics of 5-Methylcytosine Oxidation and Transcriptome Reorganization

Author(s): Shubhendu Palei, Benjamin Buchmuller, Jan Wolffgramm, Álvaro Muñoz-Lopez, Sascha Jung, Paul Czodrowski, Daniel Summerer
Published in: Journal of the American Chemical Society, Issue 142/16, 2020, Page(s) 7289-7294, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c01193

Optochemical Control of TET Dioxygenases Enables Kinetic Insights into the Domain-Dependent Interplay of TET1 and MBD1 while Oxidizing and Reading 5-Methylcytosine

Author(s): Tzu-Chen Lin, Shubhendu Palei, and Daniel Summerer
Published in: ACS Chemical Biology, 2022, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.2c00245

Light-activation of DNA-methyltransferases

Author(s): Wolffgramm, Jan; Buchmuller, Benjamin; Palei, Shubhendu; Muñoz-López, Álvaro; Kanne, Julian; Janning, Petra; Schweiger, Michal R.; Summerer, Daniel
Published in: Angewandte Chemie, 2021, Page(s) 13507-13512, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202103945

Engineered TALE Repeats for Enhanced Imaging-Based Analysis of Cellular 5-Methylcytosine.

Author(s): Álvaro Muñoz-López; Anne Jung; Benjamin Buchmuller; Jan Wolffgramm; Sara Maurer; Anna Witte; Daniel Summerer
Published in: ChemBioChem, 2020, ISSN 1439-7633
Publisher: Wiley
DOI: 10.1002/cbic.202000563

Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads

Author(s): Benjamin C. Buchmuller; Jessica Dröden; Himanshu Singh; Shubhendu Palei; Malte Drescher; Rasmus Linser; Daniel Summerer
Published in: JACS, 2022, Page(s) 2987-2993, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c10678