European Commission logo
English English
CORDIS - EU research results

Surviving metabolism: acid handling and signalling


Open Research Data

Data management plan has been implemented and the dissemination of data to the public domain can begin


Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

Author(s): Richardson SL, Hulikova A, Proven M, Hipkiss R, Akanni M, Roy NBA, Swietach P.
Published in: PNAS, Issue 117, 2020, Page(s) 10067-78, ISSN 1091-6490
Publisher: National Academy of Sciences USA
DOI: 10.1073/pnas.1916641117

What do cellular responses to acidity tell us about cancer?

Author(s): Blaszczak W, Swietach P.
Published in: Cancer Metastasis Rev, 2021, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10005-3

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Author(s): Ordway B, Tomaszewski M, Byrne S, Abrahams D, Swietach P, Gillies RJ, Damaghi M.
Published in: Cancers, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010064

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Author(s): Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ.
Published in: Nat Commun, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17756-7

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Author(s): Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Author(s): Blaszczak W, Williams H, Swietach P.
Published in: Br J Cancer, 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Author(s): Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JS, Trefely S, Milne TA, Swietach P
Published in: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Publisher: Springer Nature
DOI: 10.1038/s44161-023-00365-0

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

Author(s): Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P
Published in: Cell Reports, Issue 42, 2023, Page(s) 112601, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112601

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Author(s): Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P.
Published in: Basic Res Cardiol, 2022, ISSN 0300-8428
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00924-9

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Author(s): Stefania Monterisi; Johanna Michl; Alzbeta Hulikova; Jana Koth; Esther M Bridges; Amaryllis E Hill; Gulnar Abdullayeva; Walter F Bodmer; Pawel Swietach
Published in: Elife, Issue 11, 2022, Page(s) 78425, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78425

Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.

Author(s): Ordway B, Swietach P, Gillies RJ, Damaghi M.
Published in: Front Oncol, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00373

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients.

Author(s): Park KC, Donovan K, McKechnie S, Ramamurthy N, Klenerman P, Swietach P.
Published in: Br J Haematol, 2020, ISSN 1365-2141
Publisher: British Society for Haematology and John Wiley & Sons Ltd
DOI: 10.1111/bjh.17025

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Author(s): Johanna Michl, Kyung Chan Park, Pawel Swietach
Published in: Communications Biology, Issue 2/1, 2019, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-019-0393-7

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

Author(s): Pawel Swietach, Stefania Monterisi
Published in: Cancers, Issue 11/1, 2019, Page(s) 117, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010117

What is pH regulation, and why do cancer cells need it?

Author(s): Pawel Swietach
Published in: Cancer and Metastasis Reviews, Issue 38/1-2, 2019, Page(s) 5-15, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-09778-x

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Author(s): Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths
Published in: British Journal of Cancer, Issue 119/5, 2018, Page(s) 622-630, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0216-5

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Author(s): White B, Swietach P
Published in: Pflugers Archiv, 2023, ISSN 1432-2013
Publisher: Springer
DOI: 10.1007/s00424-023-02876-y

Proton export upregulates aerobic glycolysis.

Author(s): Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ.
Published in: BMC Biol, 2022, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-022-01340-0

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Author(s): Blaszczak W, Tan Z, Swietach P
Published in: Chemoreceptors, 2020, ISSN 2227-9040
Publisher: MDPI
DOI: 10.3390/chemosensors9060139

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Author(s): Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110796

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Author(s): Wiktoria Blaszczak; Pawel Swietach
Published in: Oncotarget, Issue 14, 2023, Page(s) 51-52, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.28351

How protons pave the way to aggressive cancers

Author(s): Swietach P, Boedtkjer E, Pedersen SF
Published in: Nature Reviews Cancer, 2023, ISSN 1474-1768
Publisher: Springer Nature
DOI: 10.1038/s41568-023-00628-9

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available