Surviving metabolism: acid handling and signalling

Deliverables

Open Research Data Pilot (1)

Open Research Data

Data management plan has been implemented and the dissemination of data to the public domain can begin

Publications

Peer reviewed articles (15)

What do cellular responses to acidity tell us about cancer?

Author(s): Blaszczak W, Swietach P.
Published in: Cancer Metastasis Rev, 2021, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10005-3

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Author(s): Ordway B, Tomaszewski M, Byrne S, Abrahams D, Swietach P, Gillies RJ, Damaghi M.
Published in: Cancers, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010064

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Author(s): Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ.
Published in: Nat Commun, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17756-7

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Author(s): Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Author(s): Blaszczak W, Williams H, Swietach P.
Published in: Br J Cancer, 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Author(s): Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P.
Published in: Basic Res Cardiol, 2022, ISSN 0300-8428
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00924-9

Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.

Author(s): Ordway B, Swietach P, Gillies RJ, Damaghi M.
Published in: Front Oncol, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00373

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients.

Author(s): Park KC, Donovan K, McKechnie S, Ramamurthy N, Klenerman P, Swietach P.
Published in: Br J Haematol, 2020, ISSN 1365-2141
Publisher: British Society for Haematology and John Wiley & Sons Ltd
DOI: 10.1111/bjh.17025

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Author(s): Johanna Michl, Kyung Chan Park, Pawel Swietach
Published in: Communications Biology, 2/1, 2019, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-019-0393-7

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

Author(s): Pawel Swietach, Stefania Monterisi
Published in: Cancers, 11/1, 2019, Page(s) 117, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010117

What is pH regulation, and why do cancer cells need it?

Author(s): Pawel Swietach
Published in: Cancer and Metastasis Reviews, 38/1-2, 2019, Page(s) 5-15, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-09778-x

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Author(s): Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths
Published in: British Journal of Cancer, 119/5, 2018, Page(s) 622-630, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0216-5

Proton export upregulates aerobic glycolysis.

Author(s): Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ.
Published in: BMC Biol, 2022, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-022-01340-0

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Author(s): Blaszczak W, Tan Z, Swietach P
Published in: Chemoreceptors, 2020, ISSN 2227-9040
Publisher: MDPI
DOI: 10.3390/chemosensors9060139

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Author(s): Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110796