Surviving metabolism: acid handling and signalling

Informazioni relative al progetto

Survive

ID dell’accordo di sovvenzione: 723997

DOI

10.3030/723997

Progetto chiuso

Data della firma CE 1 Marzo 2017

Data di avvio 1 Giugno 2017

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 922 575,00

Contributo UE

€ 1 922 575,00

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Open Research Data

Data management plan has been implemented and the dissemination of data to the public domain can begin

Pubblicazioni

Peer reviewed articles (20)

Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

Autori: Richardson SL, Hulikova A, Proven M, Hipkiss R, Akanni M, Roy NBA, Swietach P.
Pubblicato in: PNAS, Numero 117, 2020, Pagina/e 10067-78, ISSN 1091-6490
Editore: National Academy of Sciences USA
DOI: 10.1073/pnas.1916641117

What do cellular responses to acidity tell us about cancer?

Autori: Blaszczak W, Swietach P.
Pubblicato in: Cancer Metastasis Rev, 2021, ISSN 0167-7659
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10005-3

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Autori: Ordway B, Tomaszewski M, Byrne S, Abrahams D, Swietach P, Gillies RJ, Damaghi M.
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010064

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Autori: Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ.
Pubblicato in: Nat Commun, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17756-7

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Autori: Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P.
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Autori: Blaszczak W, Williams H, Swietach P.
Pubblicato in: Br J Cancer, 2022, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Autori: Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JS, Trefely S, Milne TA, Swietach P
Pubblicato in: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Editore: Springer Nature
DOI: 10.1038/s44161-023-00365-0

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

Autori: Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P
Pubblicato in: Cell Reports, Numero 42, 2023, Pagina/e 112601, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112601

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Autori: Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P.
Pubblicato in: Basic Res Cardiol, 2022, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00924-9

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Autori: Stefania Monterisi; Johanna Michl; Alzbeta Hulikova; Jana Koth; Esther M Bridges; Amaryllis E Hill; Gulnar Abdullayeva; Walter F Bodmer; Pawel Swietach
Pubblicato in: Elife, Numero 11, 2022, Pagina/e 78425, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.78425

Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.

Autori: Ordway B, Swietach P, Gillies RJ, Damaghi M.
Pubblicato in: Front Oncol, 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00373

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients.

Autori: Park KC, Donovan K, McKechnie S, Ramamurthy N, Klenerman P, Swietach P.
Pubblicato in: Br J Haematol, 2020, ISSN 1365-2141
Editore: British Society for Haematology and John Wiley & Sons Ltd
DOI: 10.1111/bjh.17025

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Autori: Johanna Michl, Kyung Chan Park, Pawel Swietach
Pubblicato in: Communications Biology, Numero 2/1, 2019, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-019-0393-7

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

Autori: Pawel Swietach, Stefania Monterisi
Pubblicato in: Cancers, Numero 11/1, 2019, Pagina/e 117, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010117

What is pH regulation, and why do cancer cells need it?

Autori: Pawel Swietach
Pubblicato in: Cancer and Metastasis Reviews, Numero 38/1-2, 2019, Pagina/e 5-15, ISSN 0167-7659
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-09778-x

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Autori: Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths
Pubblicato in: British Journal of Cancer, Numero 119/5, 2018, Pagina/e 622-630, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-018-0216-5

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Autori: White B, Swietach P
Pubblicato in: Pflugers Archiv, 2023, ISSN 1432-2013
Editore: Springer
DOI: 10.1007/s00424-023-02876-y

Proton export upregulates aerobic glycolysis.

Autori: Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ.
Pubblicato in: BMC Biol, 2022, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-022-01340-0

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Autori: Blaszczak W, Tan Z, Swietach P
Pubblicato in: Chemoreceptors, 2020, ISSN 2227-9040
Editore: MDPI
DOI: 10.3390/chemosensors9060139

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Autori: Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ.
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110796

Non-peer reviewed articles (2)

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Autori: Wiktoria Blaszczak; Pawel Swietach
Pubblicato in: Oncotarget, Numero 14, 2023, Pagina/e 51-52, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.28351

How protons pave the way to aggressive cancers

Autori: Swietach P, Boedtkjer E, Pedersen SF
Pubblicato in: Nature Reviews Cancer, 2023, ISSN 1474-1768
Editore: Springer Nature
DOI: 10.1038/s41568-023-00628-9