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Surviving metabolism: acid handling and signalling

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Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

Autores: Richardson SL, Hulikova A, Proven M, Hipkiss R, Akanni M, Roy NBA, Swietach P.
Publicado en: PNAS, Edición 117, 2020, Página(s) 10067-78, ISSN 1091-6490
Editor: National Academy of Sciences USA
DOI: 10.1073/pnas.1916641117

What do cellular responses to acidity tell us about cancer?

Autores: Blaszczak W, Swietach P.
Publicado en: Cancer Metastasis Rev, 2021, ISSN 0167-7659
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10005-3

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Autores: Ordway B, Tomaszewski M, Byrne S, Abrahams D, Swietach P, Gillies RJ, Damaghi M.
Publicado en: Cancers, 2020, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010064

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Autores: Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ.
Publicado en: Nat Commun, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17756-7

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Autores: Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P.
Publicado en: Cell Reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Autores: Blaszczak W, Williams H, Swietach P.
Publicado en: Br J Cancer, 2022, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Autores: Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JS, Trefely S, Milne TA, Swietach P
Publicado en: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Editor: Springer Nature
DOI: 10.1038/s44161-023-00365-0

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

Autores: Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P
Publicado en: Cell Reports, Edición 42, 2023, Página(s) 112601, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112601

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Autores: Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P.
Publicado en: Basic Res Cardiol, 2022, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00924-9

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Autores: Stefania Monterisi; Johanna Michl; Alzbeta Hulikova; Jana Koth; Esther M Bridges; Amaryllis E Hill; Gulnar Abdullayeva; Walter F Bodmer; Pawel Swietach
Publicado en: Elife, Edición 11, 2022, Página(s) 78425, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.78425

Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.

Autores: Ordway B, Swietach P, Gillies RJ, Damaghi M.
Publicado en: Front Oncol, 2020, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00373

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients.

Autores: Park KC, Donovan K, McKechnie S, Ramamurthy N, Klenerman P, Swietach P.
Publicado en: Br J Haematol, 2020, ISSN 1365-2141
Editor: British Society for Haematology and John Wiley & Sons Ltd
DOI: 10.1111/bjh.17025

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Autores: Johanna Michl, Kyung Chan Park, Pawel Swietach
Publicado en: Communications Biology, Edición 2/1, 2019, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-019-0393-7

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

Autores: Pawel Swietach, Stefania Monterisi
Publicado en: Cancers, Edición 11/1, 2019, Página(s) 117, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010117

What is pH regulation, and why do cancer cells need it?

Autores: Pawel Swietach
Publicado en: Cancer and Metastasis Reviews, Edición 38/1-2, 2019, Página(s) 5-15, ISSN 0167-7659
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-09778-x

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Autores: Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths
Publicado en: British Journal of Cancer, Edición 119/5, 2018, Página(s) 622-630, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-018-0216-5

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Autores: White B, Swietach P
Publicado en: Pflugers Archiv, 2023, ISSN 1432-2013
Editor: Springer
DOI: 10.1007/s00424-023-02876-y

Proton export upregulates aerobic glycolysis.

Autores: Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ.
Publicado en: BMC Biol, 2022, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-022-01340-0

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Autores: Blaszczak W, Tan Z, Swietach P
Publicado en: Chemoreceptors, 2020, ISSN 2227-9040
Editor: MDPI
DOI: 10.3390/chemosensors9060139

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Autores: Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ.
Publicado en: Cell Reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.110796

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Autores: Wiktoria Blaszczak; Pawel Swietach
Publicado en: Oncotarget, Edición 14, 2023, Página(s) 51-52, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.28351

How protons pave the way to aggressive cancers

Autores: Swietach P, Boedtkjer E, Pedersen SF
Publicado en: Nature Reviews Cancer, 2023, ISSN 1474-1768
Editor: Springer Nature
DOI: 10.1038/s41568-023-00628-9

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