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Surviving metabolism: acid handling and signalling


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Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

Autorzy: Richardson SL, Hulikova A, Proven M, Hipkiss R, Akanni M, Roy NBA, Swietach P.
Opublikowane w: PNAS, Numer 117, 2020, Strona(/y) 10067-78, ISSN 1091-6490
Wydawca: National Academy of Sciences USA
DOI: 10.1073/pnas.1916641117

What do cellular responses to acidity tell us about cancer?

Autorzy: Blaszczak W, Swietach P.
Opublikowane w: Cancer Metastasis Rev, 2021, ISSN 0167-7659
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10005-3

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Autorzy: Ordway B, Tomaszewski M, Byrne S, Abrahams D, Swietach P, Gillies RJ, Damaghi M.
Opublikowane w: Cancers, 2020, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010064

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Autorzy: Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ.
Opublikowane w: Nat Commun, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17756-7

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Autorzy: Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P.
Opublikowane w: Cell Reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Autorzy: Blaszczak W, Williams H, Swietach P.
Opublikowane w: Br J Cancer, 2022, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Autorzy: Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JS, Trefely S, Milne TA, Swietach P
Opublikowane w: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Wydawca: Springer Nature
DOI: 10.1038/s44161-023-00365-0

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

Autorzy: Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P
Opublikowane w: Cell Reports, Numer 42, 2023, Strona(/y) 112601, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2023.112601

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Autorzy: Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P.
Opublikowane w: Basic Res Cardiol, 2022, ISSN 0300-8428
Wydawca: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00924-9

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Autorzy: Stefania Monterisi; Johanna Michl; Alzbeta Hulikova; Jana Koth; Esther M Bridges; Amaryllis E Hill; Gulnar Abdullayeva; Walter F Bodmer; Pawel Swietach
Opublikowane w: Elife, Numer 11, 2022, Strona(/y) 78425, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.78425

Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.

Autorzy: Ordway B, Swietach P, Gillies RJ, Damaghi M.
Opublikowane w: Front Oncol, 2020, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00373

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients.

Autorzy: Park KC, Donovan K, McKechnie S, Ramamurthy N, Klenerman P, Swietach P.
Opublikowane w: Br J Haematol, 2020, ISSN 1365-2141
Wydawca: British Society for Haematology and John Wiley & Sons Ltd
DOI: 10.1111/bjh.17025

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Autorzy: Johanna Michl, Kyung Chan Park, Pawel Swietach
Opublikowane w: Communications Biology, Numer 2/1, 2019, ISSN 2399-3642
Wydawca: Springer Nature
DOI: 10.1038/s42003-019-0393-7

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

Autorzy: Pawel Swietach, Stefania Monterisi
Opublikowane w: Cancers, Numer 11/1, 2019, Strona(/y) 117, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010117

What is pH regulation, and why do cancer cells need it?

Autorzy: Pawel Swietach
Opublikowane w: Cancer and Metastasis Reviews, Numer 38/1-2, 2019, Strona(/y) 5-15, ISSN 0167-7659
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-09778-x

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Autorzy: Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths
Opublikowane w: British Journal of Cancer, Numer 119/5, 2018, Strona(/y) 622-630, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/s41416-018-0216-5

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Autorzy: White B, Swietach P
Opublikowane w: Pflugers Archiv, 2023, ISSN 1432-2013
Wydawca: Springer
DOI: 10.1007/s00424-023-02876-y

Proton export upregulates aerobic glycolysis.

Autorzy: Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ.
Opublikowane w: BMC Biol, 2022, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-022-01340-0

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Autorzy: Blaszczak W, Tan Z, Swietach P
Opublikowane w: Chemoreceptors, 2020, ISSN 2227-9040
Wydawca: MDPI
DOI: 10.3390/chemosensors9060139

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

Autorzy: Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ.
Opublikowane w: Cell Reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.110796

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Autorzy: Wiktoria Blaszczak; Pawel Swietach
Opublikowane w: Oncotarget, Numer 14, 2023, Strona(/y) 51-52, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.28351

How protons pave the way to aggressive cancers

Autorzy: Swietach P, Boedtkjer E, Pedersen SF
Opublikowane w: Nature Reviews Cancer, 2023, ISSN 1474-1768
Wydawca: Springer Nature
DOI: 10.1038/s41568-023-00628-9

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