Understanding the complexity and architecture in protein ubiquitination

Información del proyecto

UbiArchitect

Identificador del acuerdo de subvención: 724804

DOI

10.3030/724804

Proyecto finalizado el 31 Octubre 2018

Fecha de la firma de la CE 22 Marzo 2017

Fecha de inicio 1 Octubre 2017

Fecha de finalización 30 Septiembre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 990 125,00

Aportación de la UE

€ 1 990 125,00

Coordinado por

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

Periodic Reporting for period 1 - UbiArchitect (Understanding the complexity and architecture in protein ubiquitination)

Período documentado: 2017-10-01 hasta 2019-03-31

Resumen del contexto y de los objetivos generales del proyecto

The project 'UbiArchitect' set out to further understand architecture in ubqiutiin chains, and to reveal and understand new ubiquitin signals, using a variety of biochemical, mass-spectrometric, biophysical and structural biology techniques.

the ubiquitin system presents a large and mostly untapped translational resource, but the complexity of ubiquitin signals has been daunting for pharmaceutical efforts.

the overall objectives are to develop new methods and techniques to study ubiquitin signals by mass-spectrometry, and apply them to medically relevant pathways. a particular focus is on Parkinson;s disease.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

The 5 year project was terminated after year 1 as the principal investigator moved to Australia.

During the first year, the group addressed AIM 2a, mechanistic understanding of PINK1/Parkin mediated mitophagy, providing two Nature papers revealing the first structure of PINK1 in complex withubiquitin and a nano body, and the structure of the active form of Parkin. Significant progress was also made on AIM 1, which will be published in 2019.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

the project was terminated, and will be continued in Australia. We expect to address all aims in the next few years.