Understanding the complexity and architecture in protein ubiquitination

Informazioni relative al progetto

UbiArchitect

ID dell’accordo di sovvenzione: 724804

DOI

10.3030/724804

Progetto concluso il 31 Ottobre 2018

Data della firma CE 22 Marzo 2017

Data di avvio 1 Ottobre 2017

Data di completamento 30 Settembre 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 990 125,00

Contributo UE

€ 1 990 125,00

Coordinato da

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

Periodic Reporting for period 1 - UbiArchitect (Understanding the complexity and architecture in protein ubiquitination)

Periodo di rendicontazione: 2017-10-01 al 2019-03-31

Sintesi del contesto e degli obiettivi generali del progetto

The project 'UbiArchitect' set out to further understand architecture in ubqiutiin chains, and to reveal and understand new ubiquitin signals, using a variety of biochemical, mass-spectrometric, biophysical and structural biology techniques.

the ubiquitin system presents a large and mostly untapped translational resource, but the complexity of ubiquitin signals has been daunting for pharmaceutical efforts.

the overall objectives are to develop new methods and techniques to study ubiquitin signals by mass-spectrometry, and apply them to medically relevant pathways. a particular focus is on Parkinson;s disease.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

The 5 year project was terminated after year 1 as the principal investigator moved to Australia.

During the first year, the group addressed AIM 2a, mechanistic understanding of PINK1/Parkin mediated mitophagy, providing two Nature papers revealing the first structure of PINK1 in complex withubiquitin and a nano body, and the structure of the active form of Parkin. Significant progress was also made on AIM 1, which will be published in 2019.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

the project was terminated, and will be continued in Australia. We expect to address all aims in the next few years.