Microglial control of neuronal activity in the healthy and the injured brain

Informazioni relative al progetto

MicroCONtACT

ID dell’accordo di sovvenzione: 724994

DOI

10.3030/724994

Progetto chiuso

Data della firma CE 24 Marzo 2017

Data di avvio 1 Aprile 2017

Data di completamento 31 Marzo 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

HUN REN KISERLETI ORVOSTUDOMANYI KUTATOINTEZET
Hungary

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Autori: Csaba Cserép, Balázs Pósfai, Ádám Dénes
Pubblicato in: Neuron, Numero 109/2, 2021, Pagina/e 222-240, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.11.007

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.

Autori: Krisztina Tóth; Nikolett Lénárt; Péter Berki; Rebeka Fekete; Eszter Szabadits; Balázs Pósfai; Csaba Cserép; Ahmad Alatshan; Szilvia Benkő; Dániel Kiss; Christian A. Hübner; Attila Gulyás; Kai Kaila; Zsuzsanna Környei; Ádám Dénes
Pubblicato in: PLOS Biology, Numero 1, 2022, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001526

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Autori: Eszter Á. Tóth, Lilla Turiák, Tamás Visnovitz, Csaba Cserép, Anett Mázló, Barbara W. Sódar, András I. Försönits, Gábor Petővári, Anna Sebestyén, Zsolt Komlósi, László Drahos, Ágnes Kittel, György Nagy, Attila Bácsi, Ádám Dénes, Yong Song Gho, Katalin É. Szabó‐Taylor, Edit I. Buzás
Pubblicato in: Journal of Extracellular Vesicles, Numero 10/11, 2021, ISSN 2001-3078
Editore: Wiley
DOI: 10.1002/jev2.12140

Microglial control of neuronal development via somatic purinergic junctions

Autori: Csaba Cserp, Anett D Schwarcz, Balzs Psfai, Zsfia I Lszl, Anna Kellermayer, Zsuzsanna Krnyei, Mt Kisfali, Mikls Nyerges, Zsolt Lele, Istvn Katona, dm Dnes
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111369

Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites

Autori: Cserép, Csaba; Pósfai, Balázs; Schwarcz, Anett Dóra; Dénes, Ádám
Pubblicato in: eNeuro, Numero 1, 2018, ISSN 2373-2822
Editore: Society for Neuroscience
DOI: 10.1101/216093

Co-transmission of acetylcholine and GABA regulates hippocampal states

Autori: Virág T. Takács, Csaba Cserép, Dániel Schlingloff, Balázs Pósfai, András Szőnyi, Katalin E. Sos, Zsuzsanna Környei, Ádám Dénes, Attila I. Gulyás, Tamás F. Freund, Gábor Nyiri
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05136-1

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

Autori: Rebeka Fekete, Csaba Cserép, Nikolett Lénárt, Krisztina Tóth, Barbara Orsolits, Bernadett Martinecz, Előd Méhes, Bálint Szabó, Valéria Németh, Balázs Gönci, Beáta Sperlágh, Zsolt Boldogkői, Ágnes Kittel, Mária Baranyi, Szilamér Ferenczi, Krisztina Kovács, Gergely Szalay, Balázs Rózsa, Connor Webb, Gabor G. Kovacs, Tibor Hortobágyi, Brian L. West, Zsuzsanna Környei, Ádám D
Pubblicato in: Acta Neuropathologica, Numero 136/3, 2018, Pagina/e 461-482, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-018-1885-0

New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective

Autori: Balázs Pósfai, Csaba Cserép, Barbara Orsolits, Ádám Dénes
Pubblicato in: Neuroscience, 2018, ISSN 0306-4522
Editore: Elsevier BV
DOI: 10.1016/j.neuroscience.2018.04.046

Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms

Autori: Zsuzsanna Helyes, Valéria Tékus, Nikolett Szentes, Krisztina Pohóczky, Bálint Botz, Tamás Kiss, Ágnes Kemény, Zsuzsanna Környei, Krisztina Tóth, Nikolett Lénárt, Hajnalka Ábrahám, Emmanuel Pinteaux, Sheila Francis, Serena Sensi, Ádám Dénes, Andreas Goebel
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/26, 2019, Pagina/e 13067-13076, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1820168116

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer

Autori: Kelly L. Singel, Kassondra S. Grzankowski, A. N. M. Nazmul H. Khan, Melissa J. Grimm, Anthony C. D’Auria, Kayla Morrell, Kevin H. Eng, Bonnie Hylander, Paul C. Mayor, Tiffany R. Emmons, Nikolett Lénárt, Rebeka Fekete, Zsuzsanna Környei, Uma Muthukrishnan, Jonathan D. Gilthorpe, Constantin F. Urban, Kiyoshi Itagaki, Carl J. Hauser, Cynthia Leifer, Kirsten B. Moysich, Kunle Odunsi, Ádám Déne
Pubblicato in: British Journal of Cancer, Numero 120/2, 2019, Pagina/e 207-217, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-018-0339-8

Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia

Autori: Gergely Kovács, Zsuzsanna Környei, Krisztina Tóth, Mária Baranyi, János Brunner, Máté Neubrandt, Ádám Dénes, Beáta Sperlágh
Pubblicato in: Cell Calcium, Numero 75, 2018, Pagina/e 1-13, ISSN 0143-4160
Editore: Churchill Livingstone
DOI: 10.1016/j.ceca.2018.07.010

Novel therapeutic potential of angiotensin receptor 1 blockade in a rat model of diabetes-associated depression parallels altered BDNF signalling

Autori: Lilla Lenart, Dora B. Balogh, Nikolett Lenart, Adrienn Barczi, Adam Hosszu, Tamas Farkas, Judit Hodrea, Attila J. Szabo, Krisztian Szigeti, Adam Denes, Andrea Fekete
Pubblicato in: Diabetologia, Numero 62/8, 2019, Pagina/e 1501-1513, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-4888-z

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

Autori: Franca Orsini, Stefano Fumagalli, Eszter Császár, Krisztina Tóth, Daiana De Blasio, Rosalia Zangari, Nikolett Lénárt, Ádám Dénes, Maria-Grazia De Simoni
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 38/11, 2018, Pagina/e 2678-2690, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.311058

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Autori: Raymond Wong, Nikolett Lénárt, Laura Hill, Lauren Toms, Graham Coutts, Bernadett Martinecz, Eszter Császár, Gábor Nyiri, Athina Papaemmanouil, Ari Waisman, Werner Müller, Markus Schwaninger, Nancy Rothwell, Sheila Francis, Emmanuel Pinteaux, Adam Denés, Stuart M. Allan
Pubblicato in: Brain, Behavior, and Immunity, Numero 76, 2019, Pagina/e 126-138, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2018.11.012

Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain

Autori: Dániel P Varga, Ákos Menyhárt, Balázs Pósfai, Eszter Császár, Nikolett Lénárt, Csaba Cserép, Barbara Orsolits, Bernadett Martinecz, Tamás Szlepák, Ferenc Bari, Eszter Farkas, Ádám Dénes
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, 2020, Pagina/e 0271678X1990009, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x19900097

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

Autori: Csaba Cserép, Balázs Pósfai, Nikolett Lénárt, Rebeka Fekete, Zsófia I. László, Zsolt Lele, Barbara Orsolits, Gábor Molnár, Steffanie Heindl, Anett D. Schwarcz, Katinka Ujvári, Zsuzsanna Környei, Krisztina Tóth, Eszter Szabadits, Beáta Sperlágh, Mária Baranyi, László Csiba, Tibor Hortobágyi, Zsófia Maglóczky, Bernadett Martinecz, Gábor Szabó, Ferenc Erdélyi, Róbert Szipőcs
Pubblicato in: Science, Numero 367/6477, 2020, Pagina/e 528-537, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aax6752

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

Autori: Eszter Csszr, Nikolett Lnrt, Csaba Cserp, Zsuzsanna Krnyei, Rebeka Fekete, Balzs Psfai, Dina Balzsfi, Balzs Hangya, Anett D. Schwarcz, Eszter Szabadits, Dvid Szllsi, Krisztin Szigeti, Domokos Mth, Brian L. West, Katalin Sviatk, Ana Rita Brs, Jean-Charles Mariani, Andrea Kliewer, Zsolt Lenkei, Lszl Hricisk, Zoltn Beny, Mria Baranyi, Beta Sperlgh
Pubblicato in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Editore: Rockefeller University Press
DOI: 10.1084/jem.20211071