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Risk assessment of plaque rupture and future cardiovascular events (CVENT) by multi-spectral photoacoustic imaging

Objective

Cardiovascular disease (CVD), more specifically, vulnerable plaque rupture, remains the major cause of death for people at middle age. The CVENT consortium will revolutionize screening, diagnosis and monitoring of CVD by means of a compact photoacoustic imaging (PAI) system for vulnerable plaque imaging.
In the carotid arteries feeding the brain, vulnerable plaque rupture initiates cerebrovascular ischemic attacks. The state-of-the-art decision-making approach for a high-risk surgical intervention to avoid plaque rupture is based on stenosis severity alone, measured with ultrasound (US) imaging. However, this does not distinguish between vulnerable (rupture-prone) and stable (harmless) plaques, leading to severe overtreatment. Consequently, there is a worldwide unmet and urgent clinical need for functional information to enable in-depth diagnosis of carotid plaque vulnerability, avoiding cardiovascular events (CVENT) and reducing overtreatment risk.
The objective of the CVENT consortium is the development of a portable multimodal and multiwavelength PAI system with a 3 cm imaging depth, for diagnosis and monitoring of carotid plaque vulnerability. The combination of high optical contrast of PAI and the high resolution of US will be used to identify plaque vulnerability markers, typically lipid pools and intra-plaque haemorrhage. Improved diagnosis of carotid plaque vulnerability will lead to a significant reduction in CVD-related disability and mortality. Simultaneously, by stratifying patients into high and low risk groups, overtreatment is reduced, leading to better allocation of healthcare funds.
The CVENT consortium unites leading research groups, clinicians, industrial partners, and their expertise on R&D and a focus on exploitation, creating a breakthrough in carotid plaque vulnerability diagnosis. CVENT will bring together leading experts in the field of CVD, functional US imaging and PAI, introducing clinically applied PAI into the vascular medical arena.

Field of science

  • /natural sciences/physical sciences/acoustics/ultrasound
  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-ICT-2016-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ESAOTE EUROPE B.V.
Address
Philipsweg 1
6227AJ Maastricht
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 840 000

Participants (9)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 555 428,75
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
RUHR-UNIVERSITAET BOCHUM
Germany
EU contribution
€ 399 000
Address
Universitaetsstrasse 150
44801 Bochum
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PARIS
France
EU contribution
€ 399 000
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
LUMIBIRD
France
EU contribution
€ 865 000
Address
2 Rue Paul Sabatier
22300 Lannion
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 413 038,75
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET BERN
Switzerland
EU contribution
€ 0
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
BRIGHTLOOP SAS
France
EU contribution
€ 299 916,25
Address
Rue De Berri 8
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SILIOS TECHNOLOGIES SA
France
EU contribution
€ 265 656,25
Address
Zi Peynier Rousset, Rue Gaston Imbert Prolongée
13790 Peynier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TP21 GMBH
Germany
EU contribution
€ 223 750
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)