mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Risultati finali

Pinpointed putative novel biomarkers and advanced methodologies.

Pubblicazioni

Mechanisms for increased risk of diabetes in chronic liver diseases

Autori: Gianluca Svegliati-Baroni,Melania Gaggini,Fabrizia Carli,Chiara Barbieri,Monica Cucco,Ramy Younes,Chiara Rosso,Elisabetta Bugianesi,Amalia Gastaldelli
Pubblicato in: Liver International, Numero 14783231, 2020, ISSN 1478-3231
Editore: John Wiley & Sons Ltd
DOI: 10.1111/liv.14556

Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Autori: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Hugo Rocha,Paulo Santos,António Ascensão,Joan Ramon Torrella and José Magalhães
Pubblicato in: International Journal of Molecular Sciences, Numero 23(7), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073916

Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view.

Autori: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Pubblicato in: Frontiers in Endocrinology, Numero 16642392, 2022, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2022.898471

PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH

Autori: Amalia Gastaldelli,Silvia Sabatini,Fabrizia Carli,Melania Gaggini,Fernando Bril,Renata Belfort-DeAguiar,Vincenzo Positano,Diana Barb,Sushma Kadiyala,Stephen Harrison,Kenneth Cusi
Pubblicato in: Liver International, Numero 14783231, 2021, ISSN 1478-3231
Editore: John Wiley & Sons Ltd
DOI: 10.1111/liv.15005

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Autori: Luís Sousa,Mariana Guarda,Maria João Meneses,M Paula Macedo,Hugo Vicente Miranda
Pubblicato in: The Journal of Pathology, Numero 255(4), 2021, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5777

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Autori: Maria João Meneses,Regina Silvestre,Inês Sousa-Lima and Maria Paula Macedo
Pubblicato in: Internation Jounral of Molecular Sciences, Numero 14220067, 2019, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20164049

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Autori: Svegliati-Baroni, G.; Patrício, B.; Lioci, G.; Macedo, M.P.; Gastaldelli, A.
Pubblicato in: International Journal of Molecular Sciences, Numero 14220067, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165820

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Autori: Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagid, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavaresa, Sofia Benfeito, Susana P.Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymans, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, John G.Jones, Fernanda Borgesb, Mariusz R.Wieckowski, Paulo J. Olivei
Pubblicato in: Redox Biology, Numero 22132317, 2022, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2022.102400

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Autori: Adriana Fontes,João Ramalho-Santos,Hans Zischka,Anabela Marisa Azul
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2022, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13667

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Autori: Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Pubblicato in: Molecular Metabolism, Numero 22128778, 2019, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.015

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Autori: AlessandroRimessia,GaiaPedrialia,BiancaVezzania,AnnaTaroccoa,SaverioMarchic,Mariusz R.Wieckowski,CarlottaGiorgia,PaoloPintonae
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 10849521, 2020, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.015

Mitophagy in Cardiovascular Diseases

Autori: Giampaolo Morciano,Simone Patergnani,Massimo Bonora,Gaia Pedriali,Anna Tarocco,Esmaa Bouhamida,Saverio Marchi,Gina Ancora,Gabriele Anania,Mariusz R. Wieckowski,Carlotta Giorgi andPaolo Pinton
Pubblicato in: Journal of Clinical Medicine, Numero 20770383, 2020, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030892

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Autori: Massimo Bonora,Simone Patergnani,Daniela Ramaccini,Giampaolo Morciano,Gaia Pedriali,Asrat Endrias Kahsay,Esmaa Bouhamida,Carlotta Giorgi,Mariusz R. Wieckowski, and Paolo Pinton
Pubblicato in: Biomolecules, Numero 2218273X, 2020, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom10070998

Building-up fit muscles for the future

Autori: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Rui Carlos Costa,António Ascensão,Joan Ramon Torrella,José Magalhães
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2021, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13515

Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Autori: Federico Carbone,Agostino Di Ciaula,Sabrina Pagano,Silvia Minetti,Anna Maria Ansaldo,Daniele Ferrara,Anna Belfiore,Edoardo Elia,Stefania Pugliese,Vincenzo Ostilio Palmieri,Fabrizio Montecucco,Nicolas Vuilleumier,Piero Portincasa
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2021, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13410

Fit mothers for a healthy future

Autori: Jelena Stevanović-Silva,Jorge Beleza,Pedro Coxito,Rui Carlos Costa,António Ascensão,José Magalhães
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2022, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13596

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Autori: Arnau Panisello-Roselló, Eva Verde, Alexandre Lopez, Marta Flores, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, Georgina Hotter, Teresa Carbonell, René Adam, Joan Roselló-Catafau
Pubblicato in: Internation Journal of Molecular Sciences, Numero 14220067, 2018, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020348

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

Autori: Agnieszka Karkucinska-Wieckowska,Ines C. M. Simoes,Piotr Kalinowski,Magdalena Lebiedzinska-Arciszewska,Krzysztof Zieniewicz,Piotr Milkiewicz,Magdalena Górska-Ponikowska,Paolo Pinton,Afshan N. Malik,Marcin Krawczyk,Paulo J. Oliveira,Mariusz R. Wieckowski
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2022, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13622

Loss of postprandial insulin clearance control by Insulin-Degrading Enzyme drives dysmetabolism traits

Autori: Diego O. Borges,Rita S. Patarrão,Rogério T. Ribeiro,Rita Machado de Oliveira,Nádia Duarte,Getachew Debas Belew,Madalena Martins,Rita Andrade,João Costa,Isabel Correia,José Manuel Boavida,Rui Duarte,Luís Gardete-Correia,José Luís Medina,João F. Raposo,John G. Jones,Carlos Penha-Gonçalves,M. Paula Macedo
Pubblicato in: Metabolism - Clinical and Experimental, Numero 00260495, 2021, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2021.154735

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Autori: Inês C. M. Simões, Ricardo Amorim, José Teixeira,Agnieszka Karkucinska-Wieckowska,Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes, and Mariusz R. Wieckowski
Pubblicato in: International Journal of Molecular Sciences, Numero 14220067, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136848

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis

Autori: Sara Guerra,Gabriele Mocciaro,Amalia Gastaldelli
Pubblicato in: European Journal of Clinical Investigation, Numero 52(3), 2022, ISSN 0014-2972
Editore: Blackwell Publishing Inc.
DOI: 10.1111/eci.13695

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Autori: Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinto, Yaiza Potesa, Mariusz R. Wieckowsk
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 09254439, 2020, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2020.165834

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

Autori: Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann-Christine König, Tiago Barros Silva, Fernanda Borges, Stefanie M Hauck, Bernhard Michalke, Percy Knolle, Hans Zischka
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 2296634X, 2021, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2021.725474

Mitochondria in non-alcoholic fatty liver disease

Autori: Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Pubblicato in: The International Journal of Biochemistry & Cell Biology, Numero 95, 2018, Pagina/e 93-99, ISSN 1357-2725
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2017.12.019

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Autori: Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Pubblicato in: Hepatology Communications, Numero 2/9, 2018, Pagina/e 1080-1094, ISSN 2471-254X
Editore: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Autori: Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Pubblicato in: Biochemical Pharmacology, Numero 160, 2019, Pagina/e 34-45, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2018.11.020

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Autori: Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00593

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Autori: Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Pubblicato in: Cells, Numero 8/10, 2019, Pagina/e 1222, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells8101222

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Autori: Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Pubblicato in: Nutrients, Numero 11/12, 2019, Pagina/e 2871, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11122871

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Autori: Ricardo Amorim, Inês C. M. Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereira, Theresa Thiel, Andrea Normann, Catarina Morais, Amália S. Jurado, Mariusz R. Wieckowski, José Teixeira and Paulo J. Oliveira
Pubblicato in: Nutrients, Numero 20726643, 2021, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051723

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Autori: Gaia Pedriali,Giampaolo Morciano,Simone Patergnani,Paolo Cimaglia,Cristina Morelli,Elisa Mikus,Roberto Ferrari,Vincenzo Gasbarro,Carlotta Giorgi,Mariusz R. Wieckowski and Paolo Pinton
Pubblicato in: International Journal of Molecular Sciences, Numero 14220067, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144899

Measuring and estimating insulin resistance in clinical and research settings

Autori: Amalia Gastaldelli
Pubblicato in: Obesity - A research journal, Numero 19307381, 2022, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.23503

Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration.

Autori: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Pubblicato in: Liver International, Numero 14783231, 2022, ISSN 1478-3231
Editore: John Wiley & Sons Ltd
DOI: 10.1111/liv.15406

Big Data and Machine Learning to tackle Diabetes Managemen.

Autori: Pina AF, Meneses MJ, Sousa-Lima I, Henriques R, Raposo JF, Macedo MP.
Pubblicato in: European Journal of Clinical Investigation, Numero 13652362, 2022, ISSN 1365-2362
Editore: John Wiley & Sons Ltd
DOI: 10.1111/eci.13890

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Autori: Shanmugam H, Molina Molina E, Di Palo DM, Faienza M, Di Ciaula A, Garruti G, Wang D, Portincasa P.
Pubblicato in: Journal of Gastrointestinal and Liver Diseases, Numero 18418724, 2020, Pagina/e 99-110, ISSN 1841-8724
Editore: Editura Medicala
DOI: 10.15403/jgld-544

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Autori: Vanda Marques, Marta B. Afonso, Nina Bierig, Filipa Duarte-Ramos, Álvaro Santos-Laso, Raul Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Rita Luís, Adília Costa, Mariana V. Machado, Cristina Alonso, Enara Arretxe, José M. Alustiza, Marcin Krawczyk, Frank Lammert, Dina G. Tiniakos, Bertram Flehmig, Helena Cortez-Pinto, Jesus M. Banales, Rui E. Castro1, Andrea Normann and Cec
Pubblicato in: Frontiers in Medicine, 2021, ISSN 2296-858X
Editore: Frontiers Media SA
DOI: 10.3389/fmed.2021.683250

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Autori: Paulo J. Oliveira
Pubblicato in: European Heart Journal, Numero 15229645, 2021, ISSN 1522-9645
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehab399

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Autori: Anabela Marisa Azul,Martin Winter,Daniel Silva,Liljana Georgievska,Paulo J. Oliveira
Pubblicato in: European Journal of Clinical Investigation, Numero 52(3), 2022, ISSN 0014-2972
Editore: John Wiley & Sons
DOI: 10.1111/eci.13749

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Autori: Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Pubblicato in: Mitochondria and Longevity, 2018, Pagina/e 209-344
Editore: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

Diritti di proprietà intellettuale

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 17 809369
Data: 2017-10-16
Candidato/i: CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 17 835943
Data: 2017-12-29
Candidato/i: CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 17 809369
Data: 2017-10-16

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 17 835943
Data: 2017-12-29

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