mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Informations projet

mtFOIE GRAS

N° de convention de subvention: 734719

DOI

10.3030/734719

Projet clôturé

Date de signature de la CE 5 Decembre 2016

Date de début 1 Juin 2017

Date de fin 31 Août 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 454 500,00

Contribution de l’UE

€ 454 500,00

Coordonné par

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project Website and social media

Documents, reports (1)

Pinpointed putative novel biomarkers and advanced methodologies.

Publications

Peer reviewed articles (36)

Mechanisms for increased risk of diabetes in chronic liver diseases

Auteurs: Gianluca Svegliati-Baroni,Melania Gaggini,Fabrizia Carli,Chiara Barbieri,Monica Cucco,Ramy Younes,Chiara Rosso,Elisabetta Bugianesi,Amalia Gastaldelli
Publié dans: Liver International, Numéro 14783231, 2020, ISSN 1478-3231
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/liv.14556

Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Auteurs: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Hugo Rocha,Paulo Santos,António Ascensão,Joan Ramon Torrella and José Magalhães
Publié dans: International Journal of Molecular Sciences, Numéro 23(7), 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073916

Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view.

Auteurs: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Publié dans: Frontiers in Endocrinology, Numéro 16642392, 2022, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2022.898471

PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH

Auteurs: Amalia Gastaldelli,Silvia Sabatini,Fabrizia Carli,Melania Gaggini,Fernando Bril,Renata Belfort-DeAguiar,Vincenzo Positano,Diana Barb,Sushma Kadiyala,Stephen Harrison,Kenneth Cusi
Publié dans: Liver International, Numéro 41(11), 2021, ISSN 1478-3231
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/liv.15005

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Auteurs: Luís Sousa,Mariana Guarda,Maria João Meneses,M Paula Macedo,Hugo Vicente Miranda
Publié dans: The Journal of Pathology, Numéro 255(4), 2021, ISSN 0022-3417
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/path.5777

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Auteurs: Maria João Meneses,Regina Silvestre,Inês Sousa-Lima and Maria Paula Macedo
Publié dans: Internation Jounral of Molecular Sciences, Numéro 20(16), 2019, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20164049

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Auteurs: Svegliati-Baroni, G.; Patrício, B.; Lioci, G.; Macedo, M.P.; Gastaldelli, A.
Publié dans: International Journal of Molecular Sciences, Numéro 21/16, 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165820

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Auteurs: Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagid, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavaresa, Sofia Benfeito, Susana P.Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymans, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, John G.Jones, Fernanda Borgesb, Mariusz R.Wieckowski, Paulo J. Olivei
Publié dans: Redox Biology, Numéro 55, 2022, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2022.102400

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Auteurs: Adriana Fontes,João Ramalho-Santos,Hans Zischka,Anabela Marisa Azul
Publié dans: European Journal of Clinical Investigation, Numéro 52(3), 2022, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13667

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Auteurs: Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Publié dans: Molecular Metabolism, Numéro 32, 2019, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.015

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Auteurs: AlessandroRimessia,GaiaPedrialia,BiancaVezzania,AnnaTaroccoa,SaverioMarchic,Mariusz R.Wieckowski,CarlottaGiorgia,PaoloPintonae
Publié dans: Seminars in Cell & Developmental Biology, Numéro 10849521, 2020, ISSN 1084-9521
Éditeur: Academic Press
DOI: 10.1016/j.semcdb.2019.05.015

Mitophagy in Cardiovascular Diseases

Auteurs: Giampaolo Morciano,Simone Patergnani,Massimo Bonora,Gaia Pedriali,Anna Tarocco,Esmaa Bouhamida,Saverio Marchi,Gina Ancora,Gabriele Anania,Mariusz R. Wieckowski,Carlotta Giorgi andPaolo Pinton
Publié dans: Journal of Clinical Medicine, Numéro 20770383, 2020, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030892

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Auteurs: Massimo Bonora,Simone Patergnani,Daniela Ramaccini,Giampaolo Morciano,Gaia Pedriali,Asrat Endrias Kahsay,Esmaa Bouhamida,Carlotta Giorgi,Mariusz R. Wieckowski, and Paolo Pinton
Publié dans: Biomolecules, Numéro 2218273X, 2020, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom10070998

Building-up fit muscles for the future

Auteurs: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Rui Carlos Costa,António Ascensão,Joan Ramon Torrella,José Magalhães
Publié dans: European Journal of Clinical Investigation, Numéro 51(10), 2021, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13515

Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Auteurs: Federico Carbone,Agostino Di Ciaula,Sabrina Pagano,Silvia Minetti,Anna Maria Ansaldo,Daniele Ferrara,Anna Belfiore,Edoardo Elia,Stefania Pugliese,Vincenzo Ostilio Palmieri,Fabrizio Montecucco,Nicolas Vuilleumier,Piero Portincasa
Publié dans: European Journal of Clinical Investigation, Numéro 13652362, 2021, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13410

Fit mothers for a healthy future

Auteurs: Jelena Stevanović-Silva,Jorge Beleza,Pedro Coxito,Rui Carlos Costa,António Ascensão,José Magalhães
Publié dans: European Journal of Clinical Investigation, Numéro 52(3), 2022, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13596

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Auteurs: Arnau Panisello-Roselló, Eva Verde, Alexandre Lopez, Marta Flores, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, Georgina Hotter, Teresa Carbonell, René Adam, Joan Roselló-Catafau
Publié dans: Internation Journal of Molecular Sciences, Numéro 19(2), 2018, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020348

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

Auteurs: Agnieszka Karkucinska-Wieckowska,Ines C. M. Simoes,Piotr Kalinowski,Magdalena Lebiedzinska-Arciszewska,Krzysztof Zieniewicz,Piotr Milkiewicz,Magdalena Górska-Ponikowska,Paolo Pinton,Afshan N. Malik,Marcin Krawczyk,Paulo J. Oliveira,Mariusz R. Wieckowski
Publié dans: European Journal of Clinical Investigation, Numéro 52(3), 2022, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13622

Loss of postprandial insulin clearance control by Insulin-Degrading Enzyme drives dysmetabolism traits

Auteurs: Diego O. Borges,Rita S. Patarrão,Rogério T. Ribeiro,Rita Machado de Oliveira,Nádia Duarte,Getachew Debas Belew,Madalena Martins,Rita Andrade,João Costa,Isabel Correia,José Manuel Boavida,Rui Duarte,Luís Gardete-Correia,José Luís Medina,João F. Raposo,John G. Jones,Carlos Penha-Gonçalves,M. Paula Macedo
Publié dans: Metabolism - Clinical and Experimental, Numéro 118, 2021, ISSN 0026-0495
Éditeur: Elsevier BV
DOI: 10.1016/j.metabol.2021.154735

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Auteurs: Inês C. M. Simões, Ricardo Amorim, José Teixeira,Agnieszka Karkucinska-Wieckowska,Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes, and Mariusz R. Wieckowski
Publié dans: International Journal of Molecular Sciences, Numéro 22(13), 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136848

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis

Auteurs: Sara Guerra,Gabriele Mocciaro,Amalia Gastaldelli
Publié dans: European Journal of Clinical Investigation, Numéro 52(3), 2022, ISSN 0014-2972
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/eci.13695

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Auteurs: Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinto, Yaiza Potesa, Mariusz R. Wieckowsk
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numéro 09254439, 2020, ISSN 0925-4439
Éditeur: Elsevier BV
DOI: 10.1016/j.bbadis.2020.165834

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

Auteurs: Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann-Christine König, Tiago Barros Silva, Fernanda Borges, Stefanie M Hauck, Bernhard Michalke, Percy Knolle, Hans Zischka
Publié dans: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcell.2021.725474

Mitochondria in non-alcoholic fatty liver disease

Auteurs: Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Publié dans: The International Journal of Biochemistry & Cell Biology, Numéro 95, 2018, Page(s) 93-99, ISSN 1357-2725
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2017.12.019

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Auteurs: Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Publié dans: Hepatology Communications, Numéro 2/9, 2018, Page(s) 1080-1094, ISSN 2471-254X
Éditeur: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Auteurs: Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Publié dans: Biochemical Pharmacology, Numéro 160, 2019, Page(s) 34-45, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2018.11.020

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Auteurs: Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00593

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Auteurs: Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Publié dans: Cells, Numéro 8/10, 2019, Page(s) 1222, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells8101222

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Auteurs: Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Publié dans: Nutrients, Numéro 11/12, 2019, Page(s) 2871, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11122871

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Auteurs: Ricardo Amorim, Inês C. M. Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereira, Theresa Thiel, Andrea Normann, Catarina Morais, Amália S. Jurado, Mariusz R. Wieckowski, José Teixeira and Paulo J. Oliveira
Publié dans: Nutrients, Numéro 13(5), 2021, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051723

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Auteurs: Gaia Pedriali,Giampaolo Morciano,Simone Patergnani,Paolo Cimaglia,Cristina Morelli,Elisa Mikus,Roberto Ferrari,Vincenzo Gasbarro,Carlotta Giorgi,Mariusz R. Wieckowski and Paolo Pinton
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144899

Measuring and estimating insulin resistance in clinical and research settings

Auteurs: Amalia Gastaldelli
Publié dans: Obesity - A research journal, Numéro 19307381, 2022, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.23503

Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration.

Auteurs: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Publié dans: Liver International, Numéro 14783231, 2022, ISSN 1478-3231
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/liv.15406

Big Data and Machine Learning to tackle Diabetes Managemen.

Auteurs: Pina AF, Meneses MJ, Sousa-Lima I, Henriques R, Raposo JF, Macedo MP.
Publié dans: European Journal of Clinical Investigation, Numéro 13652362, 2022, ISSN 1365-2362
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/eci.13890

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Auteurs: Shanmugam H, Molina Molina E, Di Palo DM, Faienza M, Di Ciaula A, Garruti G, Wang D, Portincasa P.
Publié dans: Journal of Gastrointestinal and Liver Diseases, Numéro 18418724, 2020, Page(s) 99-110, ISSN 1841-8724
Éditeur: Editura Medicala
DOI: 10.15403/jgld-544

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Auteurs: Vanda Marques, Marta B. Afonso, Nina Bierig, Filipa Duarte-Ramos, Álvaro Santos-Laso, Raul Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Rita Luís, Adília Costa, Mariana V. Machado, Cristina Alonso, Enara Arretxe, José M. Alustiza, Marcin Krawczyk, Frank Lammert, Dina G. Tiniakos, Bertram Flehmig, Helena Cortez-Pinto, Jesus M. Banales, Rui E. Castro1, Andrea Normann and Cec
Publié dans: Frontiers in Medicine, 2021, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmed.2021.683250

Other (2)

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Auteurs: Paulo J. Oliveira
Publié dans: European Heart Journal, Numéro 15229645, 2021, ISSN 1522-9645
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehab399

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Auteurs: Anabela Marisa Azul,Martin Winter,Daniel Silva,Liljana Georgievska,Paulo J. Oliveira
Publié dans: European Journal of Clinical Investigation, Numéro 52(3), 2022, ISSN 0014-2972
Éditeur: John Wiley & Sons
DOI: 10.1111/eci.13749

Monographic books (1)

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Auteurs: Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Publié dans: Mitochondria and Longevity, Numéro 340, 2018, Page(s) 209-344
Éditeur: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

Droits de propriété intellectuelle

Patent (4)

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numéro de demande/publication: 17 809369
Date: 2017-10-16
Demandeur(s): UNIVERSIDADE DO PORTO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numéro de demande/publication: 17 835943
Date: 2017-12-29
Demandeur(s): UNIVERSIDADE DO PORTO

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numéro de demande/publication: 17 809369
Date: 2017-10-16
Demandeur(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numéro de demande/publication: 17 835943
Date: 2017-12-29
Demandeur(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO