mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Rezultaty

Pinpointed putative novel biomarkers and advanced methodologies.

Publikacje

Mechanisms for increased risk of diabetes in chronic liver diseases

Autorzy: Gianluca Svegliati-Baroni,Melania Gaggini,Fabrizia Carli,Chiara Barbieri,Monica Cucco,Ramy Younes,Chiara Rosso,Elisabetta Bugianesi,Amalia Gastaldelli
Opublikowane w: Liver International, Numer 14783231, 2020, ISSN 1478-3231
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/liv.14556

Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Autorzy: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Hugo Rocha,Paulo Santos,António Ascensão,Joan Ramon Torrella and José Magalhães
Opublikowane w: International Journal of Molecular Sciences, Numer 23(7), 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073916

Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view.

Autorzy: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Opublikowane w: Frontiers in Endocrinology, Numer 16642392, 2022, ISSN 1664-2392
Wydawca: Frontiers Media SA
DOI: 10.3389/fendo.2022.898471

PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH

Autorzy: Amalia Gastaldelli,Silvia Sabatini,Fabrizia Carli,Melania Gaggini,Fernando Bril,Renata Belfort-DeAguiar,Vincenzo Positano,Diana Barb,Sushma Kadiyala,Stephen Harrison,Kenneth Cusi
Opublikowane w: Liver International, Numer 14783231, 2021, ISSN 1478-3231
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/liv.15005

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Autorzy: Luís Sousa,Mariana Guarda,Maria João Meneses,M Paula Macedo,Hugo Vicente Miranda
Opublikowane w: The Journal of Pathology, Numer 255(4), 2021, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5777

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Autorzy: Maria João Meneses,Regina Silvestre,Inês Sousa-Lima and Maria Paula Macedo
Opublikowane w: Internation Jounral of Molecular Sciences, Numer 14220067, 2019, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20164049

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Autorzy: Svegliati-Baroni, G.; Patrício, B.; Lioci, G.; Macedo, M.P.; Gastaldelli, A.
Opublikowane w: International Journal of Molecular Sciences, Numer 14220067, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165820

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Autorzy: Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagid, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavaresa, Sofia Benfeito, Susana P.Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymans, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, John G.Jones, Fernanda Borgesb, Mariusz R.Wieckowski, Paulo J. Olivei
Opublikowane w: Redox Biology, Numer 22132317, 2022, ISSN 2213-2317
Wydawca: Elsevier BV
DOI: 10.1016/j.redox.2022.102400

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Autorzy: Adriana Fontes,João Ramalho-Santos,Hans Zischka,Anabela Marisa Azul
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2022, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13667

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Autorzy: Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Opublikowane w: Molecular Metabolism, Numer 22128778, 2019, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.015

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Autorzy: AlessandroRimessia,GaiaPedrialia,BiancaVezzania,AnnaTaroccoa,SaverioMarchic,Mariusz R.Wieckowski,CarlottaGiorgia,PaoloPintonae
Opublikowane w: Seminars in Cell & Developmental Biology, Numer 10849521, 2020, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2019.05.015

Mitophagy in Cardiovascular Diseases

Autorzy: Giampaolo Morciano,Simone Patergnani,Massimo Bonora,Gaia Pedriali,Anna Tarocco,Esmaa Bouhamida,Saverio Marchi,Gina Ancora,Gabriele Anania,Mariusz R. Wieckowski,Carlotta Giorgi andPaolo Pinton
Opublikowane w: Journal of Clinical Medicine, Numer 20770383, 2020, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030892

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Autorzy: Massimo Bonora,Simone Patergnani,Daniela Ramaccini,Giampaolo Morciano,Gaia Pedriali,Asrat Endrias Kahsay,Esmaa Bouhamida,Carlotta Giorgi,Mariusz R. Wieckowski, and Paolo Pinton
Opublikowane w: Biomolecules, Numer 2218273X, 2020, ISSN 2218-273X
Wydawca: MDPI
DOI: 10.3390/biom10070998

Building-up fit muscles for the future

Autorzy: Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Rui Carlos Costa,António Ascensão,Joan Ramon Torrella,José Magalhães
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2021, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13515

Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Autorzy: Federico Carbone,Agostino Di Ciaula,Sabrina Pagano,Silvia Minetti,Anna Maria Ansaldo,Daniele Ferrara,Anna Belfiore,Edoardo Elia,Stefania Pugliese,Vincenzo Ostilio Palmieri,Fabrizio Montecucco,Nicolas Vuilleumier,Piero Portincasa
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2021, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13410

Fit mothers for a healthy future

Autorzy: Jelena Stevanović-Silva,Jorge Beleza,Pedro Coxito,Rui Carlos Costa,António Ascensão,José Magalhães
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2022, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13596

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Autorzy: Arnau Panisello-Roselló, Eva Verde, Alexandre Lopez, Marta Flores, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, Georgina Hotter, Teresa Carbonell, René Adam, Joan Roselló-Catafau
Opublikowane w: Internation Journal of Molecular Sciences, Numer 14220067, 2018, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020348

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

Autorzy: Agnieszka Karkucinska-Wieckowska,Ines C. M. Simoes,Piotr Kalinowski,Magdalena Lebiedzinska-Arciszewska,Krzysztof Zieniewicz,Piotr Milkiewicz,Magdalena Górska-Ponikowska,Paolo Pinton,Afshan N. Malik,Marcin Krawczyk,Paulo J. Oliveira,Mariusz R. Wieckowski
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2022, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13622

Loss of postprandial insulin clearance control by Insulin-Degrading Enzyme drives dysmetabolism traits

Autorzy: Diego O. Borges,Rita S. Patarrão,Rogério T. Ribeiro,Rita Machado de Oliveira,Nádia Duarte,Getachew Debas Belew,Madalena Martins,Rita Andrade,João Costa,Isabel Correia,José Manuel Boavida,Rui Duarte,Luís Gardete-Correia,José Luís Medina,João F. Raposo,John G. Jones,Carlos Penha-Gonçalves,M. Paula Macedo
Opublikowane w: Metabolism - Clinical and Experimental, Numer 00260495, 2021, ISSN 0026-0495
Wydawca: Elsevier BV
DOI: 10.1016/j.metabol.2021.154735

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Autorzy: Inês C. M. Simões, Ricardo Amorim, José Teixeira,Agnieszka Karkucinska-Wieckowska,Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes, and Mariusz R. Wieckowski
Opublikowane w: International Journal of Molecular Sciences, Numer 14220067, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136848

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis

Autorzy: Sara Guerra,Gabriele Mocciaro,Amalia Gastaldelli
Opublikowane w: European Journal of Clinical Investigation, Numer 52(3), 2022, ISSN 0014-2972
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/eci.13695

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Autorzy: Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinto, Yaiza Potesa, Mariusz R. Wieckowsk
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 09254439, 2020, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2020.165834

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

Autorzy: Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann-Christine König, Tiago Barros Silva, Fernanda Borges, Stefanie M Hauck, Bernhard Michalke, Percy Knolle, Hans Zischka
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 2296634X, 2021, ISSN 2296-634X
Wydawca: Frontiers Media SA
DOI: 10.3389/fcell.2021.725474

Mitochondria in non-alcoholic fatty liver disease

Autorzy: Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Opublikowane w: The International Journal of Biochemistry & Cell Biology, Numer 95, 2018, Strona(/y) 93-99, ISSN 1357-2725
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2017.12.019

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Autorzy: Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Opublikowane w: Hepatology Communications, Numer 2/9, 2018, Strona(/y) 1080-1094, ISSN 2471-254X
Wydawca: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Autorzy: Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Opublikowane w: Biochemical Pharmacology, Numer 160, 2019, Strona(/y) 34-45, ISSN 0006-2952
Wydawca: Elsevier BV
DOI: 10.1016/j.bcp.2018.11.020

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Autorzy: Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Opublikowane w: Frontiers in Physiology, Numer 10, 2019, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00593

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Autorzy: Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Opublikowane w: Cells, Numer 8/10, 2019, Strona(/y) 1222, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells8101222

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Autorzy: Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Opublikowane w: Nutrients, Numer 11/12, 2019, Strona(/y) 2871, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11122871

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Autorzy: Ricardo Amorim, Inês C. M. Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereira, Theresa Thiel, Andrea Normann, Catarina Morais, Amália S. Jurado, Mariusz R. Wieckowski, José Teixeira and Paulo J. Oliveira
Opublikowane w: Nutrients, Numer 20726643, 2021, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051723

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Autorzy: Gaia Pedriali,Giampaolo Morciano,Simone Patergnani,Paolo Cimaglia,Cristina Morelli,Elisa Mikus,Roberto Ferrari,Vincenzo Gasbarro,Carlotta Giorgi,Mariusz R. Wieckowski and Paolo Pinton
Opublikowane w: International Journal of Molecular Sciences, Numer 14220067, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144899

Measuring and estimating insulin resistance in clinical and research settings

Autorzy: Amalia Gastaldelli
Opublikowane w: Obesity - A research journal, Numer 19307381, 2022, ISSN 1930-7381
Wydawca: Wiley-Blackwell
DOI: 10.1002/oby.23503

Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration.

Autorzy: Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Opublikowane w: Liver International, Numer 14783231, 2022, ISSN 1478-3231
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/liv.15406

Big Data and Machine Learning to tackle Diabetes Managemen.

Autorzy: Pina AF, Meneses MJ, Sousa-Lima I, Henriques R, Raposo JF, Macedo MP.
Opublikowane w: European Journal of Clinical Investigation, Numer 13652362, 2022, ISSN 1365-2362
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/eci.13890

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Autorzy: Shanmugam H, Molina Molina E, Di Palo DM, Faienza M, Di Ciaula A, Garruti G, Wang D, Portincasa P.
Opublikowane w: Journal of Gastrointestinal and Liver Diseases, Numer 18418724, 2020, Strona(/y) 99-110, ISSN 1841-8724
Wydawca: Editura Medicala
DOI: 10.15403/jgld-544

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Autorzy: Vanda Marques, Marta B. Afonso, Nina Bierig, Filipa Duarte-Ramos, Álvaro Santos-Laso, Raul Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Rita Luís, Adília Costa, Mariana V. Machado, Cristina Alonso, Enara Arretxe, José M. Alustiza, Marcin Krawczyk, Frank Lammert, Dina G. Tiniakos, Bertram Flehmig, Helena Cortez-Pinto, Jesus M. Banales, Rui E. Castro1, Andrea Normann and Cec
Opublikowane w: Frontiers in Medicine, 2021, ISSN 2296-858X
Wydawca: Frontiers Media SA
DOI: 10.3389/fmed.2021.683250

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Autorzy: Paulo J. Oliveira
Opublikowane w: European Heart Journal, Numer 15229645, 2021, ISSN 1522-9645
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehab399

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Autorzy: Anabela Marisa Azul,Martin Winter,Daniel Silva,Liljana Georgievska,Paulo J. Oliveira
Opublikowane w: European Journal of Clinical Investigation, Numer 52(3), 2022, ISSN 0014-2972
Wydawca: John Wiley & Sons
DOI: 10.1111/eci.13749

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Autorzy: Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Opublikowane w: Mitochondria and Longevity, 2018, Strona(/y) 209-344
Wydawca: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

Prawa własności intelektualnej

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 17 809369
Data: 2017-10-16
Wnioskodawca/wnioskodawcy: CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 17 835943
Data: 2017-12-29
Wnioskodawca/wnioskodawcy: CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 17 809369
Data: 2017-10-16
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DO PORTO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 17 835943
Data: 2017-12-29
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DO PORTO

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