Towards Early Molecular Diagnostics of Schizophrenia

Rezultaty

Dissemination and communication plan

Dissemination and communication plan, responsible partner: PB, M5

SZ_TEST events

Project events taking place in months 12 24 36 66

Promotional materials including a dedicated website

Promotional materials including a dedicated website, responsible partner: PB, M6

Publikacje

The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.

Autorzy: Srinivasan V, Korhonen L, Lindholm D.
Opublikowane w: Front Cell Neurosci., 2020, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.554548

Sphingolipids as Modulators of SARS-CoV-2 Infection.

Autorzy: Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D.
Opublikowane w: Front Cell Dev, 2021, ISSN 2296-634X
Wydawca: Frontiers Media S.A
DOI: 10.3389/fcell.2021.689854

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Autorzy: Tamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Shubina, Anastassia; Kiir, Carl Sander; Sirp, Alex; Timmusk, Tõnis; Palgi, Mari
Opublikowane w: Disease Models & Mechanisms, 2020, ISSN 1754-8403
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dmm.042747

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

Autorzy: Alex Sirp, Kristian Leite, Jürgen Tuvikene, Kaja Nurm, Mari Sepp & Tõnis Timmusk
Opublikowane w: Scientific Reports, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-75437-3

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice.

Autorzy: Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D
Opublikowane w: Front Mol Neurosci., 2021, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.588230

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

Autorzy: Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K
Opublikowane w: Commun Biol., 2022, ISSN 2399-3642
Wydawca: Nature Portfolio
DOI: 10.1038/s42003-022-03122-4

Functional Annotation of Custom Transcriptomes.

Autorzy: Hamid, F., Alasoo, K., Vilo, J., Makeyev, E
Opublikowane w: Methods in Molecular Biology, 2022, ISSN 1064-3745
Wydawca: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2521-7_9

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Autorzy: Jürgen Tuvikene Eli-Eelika Esvald Annika Rähni Kaie Uustalu Anna Zhuravskaya Annela Avarlaid Eugene V Makeyev Tõnis Timmusk
Opublikowane w: eLife, 2021, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.65161

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

Autorzy: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev & Corinne Houart
Opublikowane w: Nature Communications, Numer 12, 2021, Strona(/y) 1918, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-22098-z

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Autorzy: Karen Yap; Tek Hong Chung;Eugene V. Makeyev;
Opublikowane w: Molecular Cell, 2022, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2021.10.009

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia

Autorzy: Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp and Tõnis Timmusk
Opublikowane w: Journal of Biological Chemistry, Numer 297, 2021, Strona(/y) 101381, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101381

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.

Autorzy: Pupina N, Avarlaid A, Sadam H, Pihlak A, Jaago M, Tuvikene J, Rähni A, Planken A, Planken M, Kalso E, Tienari PJ, Nieminen JK, Seppänen MRJ, Vaheri A, Lindholm D, Sinisalo J, Pussinen P, Timmusk T, Palm K.
Opublikowane w: EBioMedicine, Numer 23523964, 2022, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103835

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Autorzy: Yaroslav A. Kainov, Eugene V. Makeyev
Opublikowane w: Nature Communications, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-14204-z

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Autorzy: Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
Opublikowane w: The Journal of Neuroscience, Numer 37/43, 2017, Strona(/y) 10516-10527, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1151-17.2017

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Autorzy: Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Opublikowane w: Journal of Molecular and Cellular Cardiology, Numer 121, 2018, Strona(/y) 287-296, ISSN 0022-2828
Wydawca: Academic Press
DOI: 10.1016/j.yjmcc.2018.07.248

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Autorzy: Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 5, 2017, ISSN 2296-634X
Wydawca: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00048

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients

Autorzy: Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Opublikowane w: Frontiers in Molecular Neuroscience, Numer 11, 2018, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00008

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Autorzy: Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Opublikowane w: EBioMedicine, Numer 29, 2018, Strona(/y) 47-59, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.043

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Autorzy: Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Opublikowane w: Expert Review of Proteomics, Numer 14/6, 2017, Strona(/y) 545-559, ISSN 1478-9450
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

Autorzy: Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S.C. Tan, Hong Sheng Ong, Eugene V. Makeyev
Opublikowane w: Molecular Cell, Numer 72/3, 2018, Strona(/y) 525-540.e13, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2018.08.041

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

Autorzy: Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
Opublikowane w: The Journal of Neuroscience, 2020, Strona(/y) 0367-19, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/jneurosci.0367-19.2019

Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.

Autorzy: Nurm K, Sepp M, Castany-Pladevall C, Creus-Muncunill J, Tuvikene J, Sirp A, Vihma H, Blake DJ, Perez-Navarro E, Timmusk T
Opublikowane w: eNeuro, 2021, ISSN 2373-2822
Wydawca: Society for Neuroscience
DOI: 10.1523/eneuro.0197-21.2021

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

Autorzy: Sadam H, Pihlak A, Jaago M, Pupina N, Rähni A, Toots M, Vaheri A, Nieminen JK, Siuko M, Tienari PJ, Palm K.
Opublikowane w: EBioMedicine, 2021, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103211

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Autorzy: Rähni A, Jaago M, Sadam H, Pupina N, Pihlak A, Tuvikene J, Annuk M, Mägi A, Timmusk T, Ghaemmaghami AM, Palm K.
Opublikowane w: Commun Med, 2022, ISSN 2730-664X
Wydawca: Springer
DOI: 10.1038/s43856-022-00114-7

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Autorzy: Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K.
Opublikowane w: SciRep, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-20849-6

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Autorzy: Karen Yap; Tek Hong Chung; Eugene V. Makeyev;
Opublikowane w: STAR Protocols, 2022, ISSN 2666-1667
Wydawca: Elsevier
DOI: 10.1016/j.xpro.2022.101139

Tuba8 drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

Autorzy: Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S. Tuba
Opublikowane w: Dev Cell, Numer 15345807, 2020, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2020.01.036

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design

Autorzy: Kaia Palm; Mariliis Jaago; Annika Rähnni, Nadezhda Pupina; Arno Pihlak; Helle Sadam; Annela Avarlaid; Anu Planken; Planken; Liina Haring; Eero Vasar; Miljana Bacevic; Eija Kalso; Pirkko J. Pussinen; Pentti J. Tienari;Antti Vaheri; Dan Lindholm; Tõnis Timmusk; Amir M. Ghaemmaghami;ni;
Opublikowane w: 2020
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.18.20105189

Rezultaty

Publikacje

Udostępnij tę stronę

Pobierz