Towards Early Molecular Diagnostics of Schizophrenia

Información del proyecto

SZ_TEST

Identificador del acuerdo de subvención: 734791

DOI

10.3030/734791

Proyecto cerrado

Fecha de la firma de la CE 5 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 30 Junio 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 990 000,00

Aportación de la UE

€ 990 000,00

Coordinado por

PROTOBIOS OU
Estonia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

Dissemination and communication plan

Dissemination and communication plan, responsible partner: PB, M5

SZ_TEST events

Project events taking place in months 12 24 36 66

Websites, patent fillings, videos etc. (1)

Promotional materials including a dedicated website

Promotional materials including a dedicated website, responsible partner: PB, M6

Publicaciones

Peer reviewed articles (27)

The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.

Autores: Srinivasan V, Korhonen L, Lindholm D.
Publicado en: Front Cell Neurosci., 2020, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.554548

Sphingolipids as Modulators of SARS-CoV-2 Infection.

Autores: Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D.
Publicado en: Front Cell Dev, 2021, ISSN 2296-634X
Editor: Frontiers Media S.A
DOI: 10.3389/fcell.2021.689854

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Autores: Tamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Shubina, Anastassia; Kiir, Carl Sander; Sirp, Alex; Timmusk, Tõnis; Palgi, Mari
Publicado en: Disease Models & Mechanisms, 2020, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.042747

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

Autores: Alex Sirp, Kristian Leite, Jürgen Tuvikene, Kaja Nurm, Mari Sepp & Tõnis Timmusk
Publicado en: Scientific Reports, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-75437-3

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice.

Autores: Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D
Publicado en: Front Mol Neurosci., 2021, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.588230

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

Autores: Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K
Publicado en: Commun Biol., 2022, ISSN 2399-3642
Editor: Nature Portfolio
DOI: 10.1038/s42003-022-03122-4

Functional Annotation of Custom Transcriptomes.

Autores: Hamid, F., Alasoo, K., Vilo, J., Makeyev, E
Publicado en: Methods in Molecular Biology, 2022, ISSN 1064-3745
Editor: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2521-7_9

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Autores: Jürgen Tuvikene Eli-Eelika Esvald Annika Rähni Kaie Uustalu Anna Zhuravskaya Annela Avarlaid Eugene V Makeyev Tõnis Timmusk
Publicado en: eLife, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.65161

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

Autores: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev & Corinne Houart
Publicado en: Nature Communications, Edición 12, 2021, Página(s) 1918, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22098-z

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Autores: Karen Yap; Tek Hong Chung;Eugene V. Makeyev;
Publicado en: Molecular Cell, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.10.009

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia

Autores: Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp and Tõnis Timmusk
Publicado en: Journal of Biological Chemistry, Edición 297, 2021, Página(s) 101381, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101381

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.

Autores: Pupina N, Avarlaid A, Sadam H, Pihlak A, Jaago M, Tuvikene J, Rähni A, Planken A, Planken M, Kalso E, Tienari PJ, Nieminen JK, Seppänen MRJ, Vaheri A, Lindholm D, Sinisalo J, Pussinen P, Timmusk T, Palm K.
Publicado en: EBioMedicine, 2022, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103835

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Autores: Yaroslav A. Kainov, Eugene V. Makeyev
Publicado en: Nature Communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-14204-z

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Autores: Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
Publicado en: The Journal of Neuroscience, Edición 37/43, 2017, Página(s) 10516-10527, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1151-17.2017

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Autores: Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 121, 2018, Página(s) 287-296, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2018.07.248

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Autores: Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Publicado en: Frontiers in Cell and Developmental Biology, Edición 5, 2017, ISSN 2296-634X
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00048

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients

Autores: Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Publicado en: Frontiers in Molecular Neuroscience, Edición 11, 2018, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00008

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Autores: Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Publicado en: EBioMedicine, Edición 29, 2018, Página(s) 47-59, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.043

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Autores: Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Publicado en: Expert Review of Proteomics, Edición 14/6, 2017, Página(s) 545-559, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

Autores: Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S.C. Tan, Hong Sheng Ong, Eugene V. Makeyev
Publicado en: Molecular Cell, Edición 72/3, 2018, Página(s) 525-540.e13, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2018.08.041

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

Autores: Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
Publicado en: The Journal of Neuroscience, 2020, Página(s) 0367-19, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.0367-19.2019

Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.

Autores: Nurm K, Sepp M, Castany-Pladevall C, Creus-Muncunill J, Tuvikene J, Sirp A, Vihma H, Blake DJ, Perez-Navarro E, Timmusk T
Publicado en: eNeuro, 2021, ISSN 2373-2822
Editor: Society for Neuroscience
DOI: 10.1523/eneuro.0197-21.2021

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

Autores: Sadam H, Pihlak A, Jaago M, Pupina N, Rähni A, Toots M, Vaheri A, Nieminen JK, Siuko M, Tienari PJ, Palm K.
Publicado en: EBioMedicine, 2021, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103211

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Autores: Rähni A, Jaago M, Sadam H, Pupina N, Pihlak A, Tuvikene J, Annuk M, Mägi A, Timmusk T, Ghaemmaghami AM, Palm K.
Publicado en: Commun Med, 2022, ISSN 2730-664X
Editor: Springer
DOI: 10.1038/s43856-022-00114-7

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Autores: Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K.
Publicado en: SciRep, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-20849-6

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Autores: Karen Yap; Tek Hong Chung; Eugene V. Makeyev;
Publicado en: STAR Protocols, 2022, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2022.101139

Tuba8 drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

Autores: Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S. Tuba
Publicado en: Dev Cell, Edición 15345807, 2020, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.01.036

Other (1)

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design

Autores: Kaia Palm; Mariliis Jaago; Annika Rähnni, Nadezhda Pupina; Arno Pihlak; Helle Sadam; Annela Avarlaid; Anu Planken; Planken; Liina Haring; Eero Vasar; Miljana Bacevic; Eija Kalso; Pirkko J. Pussinen; Pentti J. Tienari;Antti Vaheri; Dan Lindholm; Tõnis Timmusk; Amir M. Ghaemmaghami;ni;
Publicado en: 2020
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.18.20105189