Towards Early Molecular Diagnostics of Schizophrenia

Informations projet

SZ_TEST

N° de convention de subvention: 734791

DOI

10.3030/734791

Projet clôturé

Date de signature de la CE 5 Decembre 2016

Date de début 1 Janvier 2017

Date de fin 30 Juin 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 990 000,00

Contribution de l’UE

€ 990 000,00

Coordonné par

PROTOBIOS OU
Estonia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (2)

Dissemination and communication plan

Dissemination and communication plan, responsible partner: PB, M5

SZ_TEST events

Project events taking place in months 12 24 36 66

Websites, patent fillings, videos etc. (1)

Promotional materials including a dedicated website

Promotional materials including a dedicated website, responsible partner: PB, M6

Publications

Peer reviewed articles (27)

The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.

Auteurs: Srinivasan V, Korhonen L, Lindholm D.
Publié dans: Front Cell Neurosci., 2020, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.554548

Sphingolipids as Modulators of SARS-CoV-2 Infection.

Auteurs: Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D.
Publié dans: Front Cell Dev, 2021, ISSN 2296-634X
Éditeur: Frontiers Media S.A
DOI: 10.3389/fcell.2021.689854

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Auteurs: Tamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Shubina, Anastassia; Kiir, Carl Sander; Sirp, Alex; Timmusk, Tõnis; Palgi, Mari
Publié dans: Disease Models & Mechanisms, 2020, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.042747

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

Auteurs: Alex Sirp, Kristian Leite, Jürgen Tuvikene, Kaja Nurm, Mari Sepp & Tõnis Timmusk
Publié dans: Scientific Reports, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-75437-3

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice.

Auteurs: Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D
Publié dans: Front Mol Neurosci., 2021, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.588230

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

Auteurs: Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K
Publié dans: Commun Biol., 2022, ISSN 2399-3642
Éditeur: Nature Portfolio
DOI: 10.1038/s42003-022-03122-4

Functional Annotation of Custom Transcriptomes.

Auteurs: Hamid, F., Alasoo, K., Vilo, J., Makeyev, E
Publié dans: Methods in Molecular Biology, 2022, ISSN 1064-3745
Éditeur: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2521-7_9

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Auteurs: Jürgen Tuvikene Eli-Eelika Esvald Annika Rähni Kaie Uustalu Anna Zhuravskaya Annela Avarlaid Eugene V Makeyev Tõnis Timmusk
Publié dans: eLife, 2021, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.65161

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

Auteurs: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev & Corinne Houart
Publié dans: Nature Communications, Numéro 12, 2021, Page(s) 1918, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-22098-z

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Auteurs: Karen Yap; Tek Hong Chung;Eugene V. Makeyev;
Publié dans: Molecular Cell, 2022, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2021.10.009

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia

Auteurs: Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp and Tõnis Timmusk
Publié dans: Journal of Biological Chemistry, Numéro 297, 2021, Page(s) 101381, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101381

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.

Auteurs: Pupina N, Avarlaid A, Sadam H, Pihlak A, Jaago M, Tuvikene J, Rähni A, Planken A, Planken M, Kalso E, Tienari PJ, Nieminen JK, Seppänen MRJ, Vaheri A, Lindholm D, Sinisalo J, Pussinen P, Timmusk T, Palm K.
Publié dans: EBioMedicine, 2022, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103835

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Auteurs: Yaroslav A. Kainov, Eugene V. Makeyev
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-14204-z

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Auteurs: Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
Publié dans: The Journal of Neuroscience, Numéro 37/43, 2017, Page(s) 10516-10527, ISSN 0270-6474
Éditeur: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1151-17.2017

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Auteurs: Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Publié dans: Journal of Molecular and Cellular Cardiology, Numéro 121, 2018, Page(s) 287-296, ISSN 0022-2828
Éditeur: Academic Press
DOI: 10.1016/j.yjmcc.2018.07.248

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Auteurs: Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 5, 2017, ISSN 2296-634X
Éditeur: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00048

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients

Auteurs: Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Publié dans: Frontiers in Molecular Neuroscience, Numéro 11, 2018, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00008

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Auteurs: Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Publié dans: EBioMedicine, Numéro 29, 2018, Page(s) 47-59, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.043

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Auteurs: Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Publié dans: Expert Review of Proteomics, Numéro 14/6, 2017, Page(s) 545-559, ISSN 1478-9450
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

Auteurs: Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S.C. Tan, Hong Sheng Ong, Eugene V. Makeyev
Publié dans: Molecular Cell, Numéro 72/3, 2018, Page(s) 525-540.e13, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2018.08.041

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

Auteurs: Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
Publié dans: The Journal of Neuroscience, 2020, Page(s) 0367-19, ISSN 0270-6474
Éditeur: Society for Neuroscience
DOI: 10.1523/jneurosci.0367-19.2019

Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.

Auteurs: Nurm K, Sepp M, Castany-Pladevall C, Creus-Muncunill J, Tuvikene J, Sirp A, Vihma H, Blake DJ, Perez-Navarro E, Timmusk T
Publié dans: eNeuro, 2021, ISSN 2373-2822
Éditeur: Society for Neuroscience
DOI: 10.1523/eneuro.0197-21.2021

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

Auteurs: Sadam H, Pihlak A, Jaago M, Pupina N, Rähni A, Toots M, Vaheri A, Nieminen JK, Siuko M, Tienari PJ, Palm K.
Publié dans: EBioMedicine, 2021, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103211

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Auteurs: Rähni A, Jaago M, Sadam H, Pupina N, Pihlak A, Tuvikene J, Annuk M, Mägi A, Timmusk T, Ghaemmaghami AM, Palm K.
Publié dans: Commun Med, 2022, ISSN 2730-664X
Éditeur: Springer
DOI: 10.1038/s43856-022-00114-7

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Auteurs: Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K.
Publié dans: SciRep, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-20849-6

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Auteurs: Karen Yap; Tek Hong Chung; Eugene V. Makeyev;
Publié dans: STAR Protocols, 2022, ISSN 2666-1667
Éditeur: Elsevier
DOI: 10.1016/j.xpro.2022.101139

Tuba8 drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

Auteurs: Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S. Tuba
Publié dans: Dev Cell, Numéro 15345807, 2020, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2020.01.036

Other (1)

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design

Auteurs: Kaia Palm; Mariliis Jaago; Annika Rähnni, Nadezhda Pupina; Arno Pihlak; Helle Sadam; Annela Avarlaid; Anu Planken; Planken; Liina Haring; Eero Vasar; Miljana Bacevic; Eija Kalso; Pirkko J. Pussinen; Pentti J. Tienari;Antti Vaheri; Dan Lindholm; Tõnis Timmusk; Amir M. Ghaemmaghami;ni;
Publié dans: 2020
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.18.20105189