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Towards an active bypass for neural reconnection

Deliverables

First four-bridge magnetic sensor

Design, fabrication and first characterization in EM shielded environment of a first version of a magnetic sensor formed by four LSMO based anisotropic magnetoresistance elements

Functional artificial neuron

Assembly of an artificial neuron: an electronic device that will generate an electrical signal equivalent to that of a neuron in magnitude and temporal scale. This will be used as testing workbench of the magnetic-field sensors.

Bypass prototype

Bypass prototype using the developed sensors and stimulating electrodes

First nanostructured electrode

Fabrication of a first version of nanowire-coated elements using template-assisted electrochemical deposition

First nanostructured electrode on neuron-accesible substrates

Fabrication of a nanowire-coated element on a substrate suitable for accesing a neural sample

Social network sites

We will create a Linked-In group, and Facebook and Twitter profiles. Using as starting point the already existing networks of MFD, we will be invite representatives from the healthcare industry to join it. We will identify, join and actively contribute to other existing social-network groups related to brain-machine interfaces, especially those applied to spinal cord injuries.

Four non-specialists lectures

We will give at least one scientific dissemination lecture per year

Organization of several events for dissemination

Every year, we will participate in several dissemination events as Open Days, Researcher’s Night, and local Science Weeks.

Website and project logo

A website will be open with the project logo, and will be continuously updated

Public report on biocompatibility in vitro 2

Second public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes.

Public report on biocompatibility in vitro 3

Third public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

Dissemination and Exploitation Plan

We will create a Dissemination and Exploitation Plan

Report on electrophysiological tests 2

Updated report on the performance of the fabricated magnetic-field sensors and nanostructured contacts in organotypic cultures.

Public report on the bypass elements performance in organotypic systems

A public report on the ability to interface signalling with high resolution in organotypic systems

Public report summarizing results of the biocompatibility in vitro

A public report on the biocompatibility in vitro of the fabricated nanomaterial-based devices

Public report on device development

Public report about the development and performance of the new neural interfaces

Report on the magnetic sensor and nanostructured electrode development

Reports on the status of the magnetic sensors and nanowire-coated electrodes development.

Public report on device development and performance

Public report about the development and performance of the new neural interfaces

Report on the bypass elements performance in vitro

Report on the performance of the nanostructured electrodes for sensing and triggering synaptic signals both in individual neurons and in organotypic spinal cord cultures. A second updated report will be produced in month 48.

Public report on the magnetic sensors and nanostructured electrodes development

A public report about the development status of both the magnetic sensors and the nanowire-coated electrodes

Public report on biocompatibility in vitro 1

First public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

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Publications

Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation

Author(s): Matteo Manzati, Teresa Sorbo, Michele Giugliano, Laura Ballerini
Published in: Molecular Brain, 13/1, 2020, Page(s) 78, ISSN 1756-6606
Publisher: BioMed Central
DOI: 10.1186/s13041-020-00619-z

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

Author(s): Ana Domínguez‐Bajo, Beatriz Loreto Rodilla, Ivo Calaresu, Ana Arché‐Núñez, Ankor González‐Mayorga, Denis Scaini, Lucas Pérez, Julio Camarero, Rodolfo Miranda, Elisa López‐Dolado, María Teresa González, Laura Ballerini, María Concepción Serrano
Published in: Advanced Biosystems, 4/9, 2020, Page(s) 2000117, ISSN 2366-7478
Publisher: Wiley Online Library
DOI: 10.1002/adbi.202000117

Hybrid Interfaces Made of Nanotubes and Backbone-Altered Dipeptides Tune Neuronal Network Architecture

Author(s): Bhimareddy Dinesh, Manuela Medelin, Denis Scaini, Federica Lareno Faccini, Federica Quici, Laura Ballerini, Alberto Bianco
Published in: ACS Chemical Neuroscience, 11/2, 2019, Page(s) 162-172, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.9b00522

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds

Author(s): Sadaf Usmani, Audrey Franceschi Biagioni, Manuela Medelin, Denis Scaini, Raffaele Casani, Emily R. Aurand, Daniel Padro, Ander Egimendia, Pedro Ramos Cabrer, Manuela Scarselli, Maurizio De Crescenzi, Maurizio Prato, Laura Ballerini
Published in: Proceedings of the National Academy of Sciences, 117/41, 2020, Page(s) 25212-25218, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2005708117

Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces

Author(s): Niccolò Paolo Pampaloni, Denis Scaini, Fabio Perissinotto, Susanna Bosi, Maurizio Prato, Laura Ballerini
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, 14/7, 2018, Page(s) 2521-2532, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2017.01.020

Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling

Author(s): Myriam Barrejón, Rossana Rauti, Laura Ballerini, Maurizio Prato
Published in: ACS Nano, 13/8, 2019, Page(s) 8879-8889, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b02429

Engineering Large Anisotropic Magnetoresistance in La 0.7 Sr 0.3 MnO 3 Films at Room Temperature

Author(s): Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence Méchin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero
Published in: Advanced Functional Materials, 27/26, 2017, Page(s) 1700664, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700664

Favorable Biological Responses of Neural Cells and Tissue Interacting with Graphene Oxide Microfibers

Author(s): Ankor González-Mayorga, Elisa López-Dolado, María C. Gutiérrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, María C. Serrano
Published in: ACS Omega, 2/11, 2017, Page(s) 8253-8263, ISSN 2470-1343
Publisher: ACS Omega
DOI: 10.1021/acsomega.7b01354

Nanostructures to Engineer 3D Neural-Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments

Author(s): Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini
Published in: Advanced Functional Materials, 28/12, 2018, Page(s) 1700550, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700550

Room temperature biaxial magnetic anisotropy in La 0.67 Sr 0.33 MnO 3 thin films on SrTiO 3 buffered MgO (001) substrates for spintronic applications

Author(s): Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin
Published in: Applied Physics Letters, 113/5, 2018, Page(s) 052403, ISSN 0003-6951
Publisher: American Institute of Physics
DOI: 10.1063/1.5020072

Transparent carbon nanotubes promote the outgrowth of enthorino‐dentate projections in lesioned organ slice cultures

Author(s): Niccolò P. Pampaloni, Ilaria Rago, Ivo Calaresu, Luca Cozzarini, Loredana Casalis, Andrea Goldoni, Laura Ballerini, Denis Scaini
Published in: Developmental Neurobiology, 80/9-10, 2020, Page(s) 316-331, ISSN 1932-8451
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dneu.22711

Diseño y desarrollo de biomateriales para la reparación de la médula espinal lesionada

Author(s): Domínguez-Bajo, Ana
Published in: Design and development of biomaterials for spinal cord injury repair, 2020
Publisher: DIGITAL.CSIC

Magnetic Sensors Based on AMR Effect in LSMO Thin Films

Author(s): Olivier Rousseau, Stéphane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence Méchin
Published in: Proceedings, 1/4, 2017, Page(s) 635, ISSN 2504-3900
Publisher: Proceedings of Eurosensors 2017
DOI: 10.3390/proceedings1040635

Low-frequency noise considerations for sensors based on manganites

Author(s): Guillet, Bruno; Flament, Stéphane; Liu, Shuang; Rousseau, Olivier; Aryan, Ammar; Lam Chok Sing, Marc; Méchin, Laurence; Routoure, Jean-Marc; enger, luiz,; Lebargy, Sylvain; Nascimento, Vanuza,; Wu, Sheng
Published in: https://hal-normandie-univ.archives-ouvertes.fr/hal-02336146, 1, 2019
Publisher: 25th International Conference on Noise and Fluctuations (ICNF 2019), 18 - 21 June 2019
DOI: 10.5075/epfl-iclab-icnf-269309