Towards an active bypass for neural reconnection

Información del proyecto

ByAxon

Identificador del acuerdo de subvención: 737116

DOI

10.3030/737116

Proyecto cerrado

Fecha de la firma de la CE 13 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Diciembre 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 752 057,50

Aportación de la UE

€ 3 752 057,50

Coordinado por

FUNDACION IMDEA NANOCIENCIA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (5)

First four-bridge magnetic sensor

Design, fabrication and first characterization in EM shielded environment of a first version of a magnetic sensor formed by four LSMO based anisotropic magnetoresistance elements

Functional artificial neuron

Assembly of an artificial neuron: an electronic device that will generate an electrical signal equivalent to that of a neuron in magnitude and temporal scale. This will be used as testing workbench of the magnetic-field sensors.

Bypass prototype

Bypass prototype using the developed sensors and stimulating electrodes

First nanostructured electrode

Fabrication of a first version of nanowire-coated elements using template-assisted electrochemical deposition

First nanostructured electrode on neuron-accesible substrates

Fabrication of a nanowire-coated element on a substrate suitable for accesing a neural sample

Websites, patent fillings, videos etc. (4)

Social network sites

We will create a Linked-In group, and Facebook and Twitter profiles. Using as starting point the already existing networks of MFD, we will be invite representatives from the healthcare industry to join it. We will identify, join and actively contribute to other existing social-network groups related to brain-machine interfaces, especially those applied to spinal cord injuries.

Four non-specialists lectures

We will give at least one scientific dissemination lecture per year

Organization of several events for dissemination

Every year, we will participate in several dissemination events as Open Days, Researcher’s Night, and local Science Weeks.

Website and project logo

A website will be open with the project logo, and will be continuously updated

Documents, reports (12)

Public report on biocompatibility in vitro 2

Second public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes.

Public report on biocompatibility in vitro 3

Third public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

Dissemination and Exploitation Plan

We will create a Dissemination and Exploitation Plan

Report on electrophysiological tests 2

Updated report on the performance of the fabricated magnetic-field sensors and nanostructured contacts in organotypic cultures.

Public report on the bypass elements performance in organotypic systems

A public report on the ability to interface signalling with high resolution in organotypic systems

Public report summarizing results of the biocompatibility in vitro

A public report on the biocompatibility in vitro of the fabricated nanomaterial-based devices

Public report on device development

Public report about the development and performance of the new neural interfaces

Report on the magnetic sensor and nanostructured electrode development

Reports on the status of the magnetic sensors and nanowire-coated electrodes development.

Public report on device development and performance

Public report about the development and performance of the new neural interfaces

Report on the bypass elements performance in vitro

Report on the performance of the nanostructured electrodes for sensing and triggering synaptic signals both in individual neurons and in organotypic spinal cord cultures. A second updated report will be produced in month 48.

Public report on the magnetic sensors and nanostructured electrodes development

A public report about the development status of both the magnetic sensors and the nanowire-coated electrodes

Public report on biocompatibility in vitro 1

First public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

Publicaciones

Peer reviewed articles (11)

Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation

Autores: Matteo Manzati, Teresa Sorbo, Michele Giugliano, Laura Ballerini
Publicado en: Molecular Brain, Edición 13/1, 2020, Página(s) 78, ISSN 1756-6606
Editor: BioMed Central
DOI: 10.1186/s13041-020-00619-z

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

Autores: Ana Domínguez‐Bajo, Beatriz Loreto Rodilla, Ivo Calaresu, Ana Arché‐Núñez, Ankor González‐Mayorga, Denis Scaini, Lucas Pérez, Julio Camarero, Rodolfo Miranda, Elisa López‐Dolado, María Teresa González, Laura Ballerini, María Concepción Serrano
Publicado en: Advanced Biosystems, Edición 4/9, 2020, Página(s) 2000117, ISSN 2366-7478
Editor: Wiley Online Library
DOI: 10.1002/adbi.202000117

Hybrid Interfaces Made of Nanotubes and Backbone-Altered Dipeptides Tune Neuronal Network Architecture

Autores: Bhimareddy Dinesh, Manuela Medelin, Denis Scaini, Federica Lareno Faccini, Federica Quici, Laura Ballerini, Alberto Bianco
Publicado en: ACS Chemical Neuroscience, Edición 11/2, 2019, Página(s) 162-172, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.9b00522

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds

Autores: Sadaf Usmani, Audrey Franceschi Biagioni, Manuela Medelin, Denis Scaini, Raffaele Casani, Emily R. Aurand, Daniel Padro, Ander Egimendia, Pedro Ramos Cabrer, Manuela Scarselli, Maurizio De Crescenzi, Maurizio Prato, Laura Ballerini
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/41, 2020, Página(s) 25212-25218, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2005708117

Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces

Autores: Niccolò Paolo Pampaloni, Denis Scaini, Fabio Perissinotto, Susanna Bosi, Maurizio Prato, Laura Ballerini
Publicado en: Nanomedicine: Nanotechnology, Biology and Medicine, Edición 14/7, 2018, Página(s) 2521-2532, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2017.01.020

Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling

Autores: Myriam Barrejón, Rossana Rauti, Laura Ballerini, Maurizio Prato
Publicado en: ACS Nano, Edición 13/8, 2019, Página(s) 8879-8889, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.9b02429

Engineering Large Anisotropic Magnetoresistance in La 0.7 Sr 0.3 MnO 3 Films at Room Temperature

Autores: Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence Méchin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero
Publicado en: Advanced Functional Materials, Edición 27/26, 2017, Página(s) 1700664, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700664

Favorable Biological Responses of Neural Cells and Tissue Interacting with Graphene Oxide Microfibers

Autores: Ankor González-Mayorga, Elisa López-Dolado, María C. Gutiérrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, María C. Serrano
Publicado en: ACS Omega, Edición 2/11, 2017, Página(s) 8253-8263, ISSN 2470-1343
Editor: ACS Omega
DOI: 10.1021/acsomega.7b01354

Nanostructures to Engineer 3D Neural-Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments

Autores: Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini
Publicado en: Advanced Functional Materials, Edición 28/12, 2018, Página(s) 1700550, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700550

Room temperature biaxial magnetic anisotropy in La 0.67 Sr 0.33 MnO 3 thin films on SrTiO 3 buffered MgO (001) substrates for spintronic applications

Autores: Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin
Publicado en: Applied Physics Letters, Edición 113/5, 2018, Página(s) 052403, ISSN 0003-6951
Editor: American Institute of Physics
DOI: 10.1063/1.5020072

Transparent carbon nanotubes promote the outgrowth of enthorino‐dentate projections in lesioned organ slice cultures

Autores: Niccolò P. Pampaloni, Ilaria Rago, Ivo Calaresu, Luca Cozzarini, Loredana Casalis, Andrea Goldoni, Laura Ballerini, Denis Scaini
Publicado en: Developmental Neurobiology, Edición 80/9-10, 2020, Página(s) 316-331, ISSN 1932-8451
Editor: John Wiley & Sons Inc.
DOI: 10.1002/dneu.22711

Thesis and dissertations (1)

Diseño y desarrollo de biomateriales para la reparación de la médula espinal lesionada

Autores: Domínguez-Bajo, Ana
Publicado en: Design and development of biomaterials for spinal cord injury repair, 2020
Editor: DIGITAL.CSIC

Non-peer reviewed articles (1)

Magnetic Sensors Based on AMR Effect in LSMO Thin Films

Autores: Olivier Rousseau, Stéphane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence Méchin
Publicado en: Proceedings, Edición 1/4, 2017, Página(s) 635, ISSN 2504-3900
Editor: Proceedings of Eurosensors 2017
DOI: 10.3390/proceedings1040635

Conference proceedings (1)

Low-frequency noise considerations for sensors based on manganites

Autores: Guillet, Bruno; Flament, Stéphane; Liu, Shuang; Rousseau, Olivier; Aryan, Ammar; Lam Chok Sing, Marc; Méchin, Laurence; Routoure, Jean-Marc; enger, luiz,; Lebargy, Sylvain; Nascimento, Vanuza,; Wu, Sheng
Publicado en: https://hal-normandie-univ.archives-ouvertes.fr/hal-02336146, Edición 1, 2019
Editor: 25th International Conference on Noise and Fluctuations (ICNF 2019), 18 - 21 June 2019
DOI: 10.5075/epfl-iclab-icnf-269309