Towards an active bypass for neural reconnection

Projektinformationen

ByAxon

ID Finanzhilfevereinbarung: 737116

DOI

10.3030/737116

Projekt abgeschlossen

EK-Unterschriftsdatum 13 Dezember 2016

Startdatum 1 Januar 2017

Enddatum 31 Dezember 2020

Finanziert unter

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Gesamtkosten

€ 3 752 057,50

EU-Beitrag

€ 3 752 057,50

Koordiniert durch

FUNDACION IMDEA NANOCIENCIA
Spain

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Demonstrators, pilots, prototypes (5)

First four-bridge magnetic sensor

Design, fabrication and first characterization in EM shielded environment of a first version of a magnetic sensor formed by four LSMO based anisotropic magnetoresistance elements

Functional artificial neuron

Assembly of an artificial neuron: an electronic device that will generate an electrical signal equivalent to that of a neuron in magnitude and temporal scale. This will be used as testing workbench of the magnetic-field sensors.

Bypass prototype

Bypass prototype using the developed sensors and stimulating electrodes

First nanostructured electrode

Fabrication of a first version of nanowire-coated elements using template-assisted electrochemical deposition

First nanostructured electrode on neuron-accesible substrates

Fabrication of a nanowire-coated element on a substrate suitable for accesing a neural sample

Websites, patent fillings, videos etc. (4)

Social network sites

We will create a Linked-In group, and Facebook and Twitter profiles. Using as starting point the already existing networks of MFD, we will be invite representatives from the healthcare industry to join it. We will identify, join and actively contribute to other existing social-network groups related to brain-machine interfaces, especially those applied to spinal cord injuries.

Four non-specialists lectures

We will give at least one scientific dissemination lecture per year

Organization of several events for dissemination

Every year, we will participate in several dissemination events as Open Days, Researcher’s Night, and local Science Weeks.

Website and project logo

A website will be open with the project logo, and will be continuously updated

Documents, reports (12)

Public report on biocompatibility in vitro 2

Second public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes.

Public report on biocompatibility in vitro 3

Third public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

Dissemination and Exploitation Plan

We will create a Dissemination and Exploitation Plan

Report on electrophysiological tests 2

Updated report on the performance of the fabricated magnetic-field sensors and nanostructured contacts in organotypic cultures.

Public report on the bypass elements performance in organotypic systems

A public report on the ability to interface signalling with high resolution in organotypic systems

Public report summarizing results of the biocompatibility in vitro

A public report on the biocompatibility in vitro of the fabricated nanomaterial-based devices

Public report on device development

Public report about the development and performance of the new neural interfaces

Report on the magnetic sensor and nanostructured electrode development

Reports on the status of the magnetic sensors and nanowire-coated electrodes development.

Public report on device development and performance

Public report about the development and performance of the new neural interfaces

Report on the bypass elements performance in vitro

Report on the performance of the nanostructured electrodes for sensing and triggering synaptic signals both in individual neurons and in organotypic spinal cord cultures. A second updated report will be produced in month 48.

Public report on the magnetic sensors and nanostructured electrodes development

A public report about the development status of both the magnetic sensors and the nanowire-coated electrodes

Public report on biocompatibility in vitro 1

First public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes

Veröffentlichungen

Peer reviewed articles (11)

Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation

Autoren: Matteo Manzati, Teresa Sorbo, Michele Giugliano, Laura Ballerini
Veröffentlicht in: Molecular Brain, Ausgabe 13/1, 2020, Seite(n) 78, ISSN 1756-6606
Herausgeber: BioMed Central
DOI: 10.1186/s13041-020-00619-z

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

Autoren: Ana Domínguez‐Bajo, Beatriz Loreto Rodilla, Ivo Calaresu, Ana Arché‐Núñez, Ankor González‐Mayorga, Denis Scaini, Lucas Pérez, Julio Camarero, Rodolfo Miranda, Elisa López‐Dolado, María Teresa González, Laura Ballerini, María Concepción Serrano
Veröffentlicht in: Advanced Biosystems, Ausgabe 4/9, 2020, Seite(n) 2000117, ISSN 2366-7478
Herausgeber: Wiley Online Library
DOI: 10.1002/adbi.202000117

Hybrid Interfaces Made of Nanotubes and Backbone-Altered Dipeptides Tune Neuronal Network Architecture

Autoren: Bhimareddy Dinesh, Manuela Medelin, Denis Scaini, Federica Lareno Faccini, Federica Quici, Laura Ballerini, Alberto Bianco
Veröffentlicht in: ACS Chemical Neuroscience, Ausgabe 11/2, 2019, Seite(n) 162-172, ISSN 1948-7193
Herausgeber: American Chemical Society
DOI: 10.1021/acschemneuro.9b00522

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds

Autoren: Sadaf Usmani, Audrey Franceschi Biagioni, Manuela Medelin, Denis Scaini, Raffaele Casani, Emily R. Aurand, Daniel Padro, Ander Egimendia, Pedro Ramos Cabrer, Manuela Scarselli, Maurizio De Crescenzi, Maurizio Prato, Laura Ballerini
Veröffentlicht in: Proceedings of the National Academy of Sciences, Ausgabe 117/41, 2020, Seite(n) 25212-25218, ISSN 0027-8424
Herausgeber: National Academy of Sciences
DOI: 10.1073/pnas.2005708117

Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces

Autoren: Niccolò Paolo Pampaloni, Denis Scaini, Fabio Perissinotto, Susanna Bosi, Maurizio Prato, Laura Ballerini
Veröffentlicht in: Nanomedicine: Nanotechnology, Biology and Medicine, Ausgabe 14/7, 2018, Seite(n) 2521-2532, ISSN 1549-9634
Herausgeber: Elsevier BV
DOI: 10.1016/j.nano.2017.01.020

Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling

Autoren: Myriam Barrejón, Rossana Rauti, Laura Ballerini, Maurizio Prato
Veröffentlicht in: ACS Nano, Ausgabe 13/8, 2019, Seite(n) 8879-8889, ISSN 1936-0851
Herausgeber: American Chemical Society
DOI: 10.1021/acsnano.9b02429

Engineering Large Anisotropic Magnetoresistance in La 0.7 Sr 0.3 MnO 3 Films at Room Temperature

Autoren: Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence Méchin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero
Veröffentlicht in: Advanced Functional Materials, Ausgabe 27/26, 2017, Seite(n) 1700664, ISSN 1616-301X
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700664

Favorable Biological Responses of Neural Cells and Tissue Interacting with Graphene Oxide Microfibers

Autoren: Ankor González-Mayorga, Elisa López-Dolado, María C. Gutiérrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, María C. Serrano
Veröffentlicht in: ACS Omega, Ausgabe 2/11, 2017, Seite(n) 8253-8263, ISSN 2470-1343
Herausgeber: ACS Omega
DOI: 10.1021/acsomega.7b01354

Nanostructures to Engineer 3D Neural-Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments

Autoren: Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini
Veröffentlicht in: Advanced Functional Materials, Ausgabe 28/12, 2018, Seite(n) 1700550, ISSN 1616-301X
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201700550

Room temperature biaxial magnetic anisotropy in La 0.67 Sr 0.33 MnO 3 thin films on SrTiO 3 buffered MgO (001) substrates for spintronic applications

Autoren: Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin
Veröffentlicht in: Applied Physics Letters, Ausgabe 113/5, 2018, Seite(n) 052403, ISSN 0003-6951
Herausgeber: American Institute of Physics
DOI: 10.1063/1.5020072

Transparent carbon nanotubes promote the outgrowth of enthorino‐dentate projections in lesioned organ slice cultures

Autoren: Niccolò P. Pampaloni, Ilaria Rago, Ivo Calaresu, Luca Cozzarini, Loredana Casalis, Andrea Goldoni, Laura Ballerini, Denis Scaini
Veröffentlicht in: Developmental Neurobiology, Ausgabe 80/9-10, 2020, Seite(n) 316-331, ISSN 1932-8451
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/dneu.22711

Thesis and dissertations (1)

Diseño y desarrollo de biomateriales para la reparación de la médula espinal lesionada

Autoren: Domínguez-Bajo, Ana
Veröffentlicht in: Design and development of biomaterials for spinal cord injury repair, 2020
Herausgeber: DIGITAL.CSIC

Non-peer reviewed articles (1)

Magnetic Sensors Based on AMR Effect in LSMO Thin Films

Autoren: Olivier Rousseau, Stéphane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence Méchin
Veröffentlicht in: Proceedings, Ausgabe 1/4, 2017, Seite(n) 635, ISSN 2504-3900
Herausgeber: Proceedings of Eurosensors 2017
DOI: 10.3390/proceedings1040635

Conference proceedings (1)

Low-frequency noise considerations for sensors based on manganites

Autoren: Guillet, Bruno; Flament, Stéphane; Liu, Shuang; Rousseau, Olivier; Aryan, Ammar; Lam Chok Sing, Marc; Méchin, Laurence; Routoure, Jean-Marc; enger, luiz,; Lebargy, Sylvain; Nascimento, Vanuza,; Wu, Sheng
Veröffentlicht in: https://hal-normandie-univ.archives-ouvertes.fr/hal-02336146, Ausgabe 1, 2019
Herausgeber: 25th International Conference on Noise and Fluctuations (ICNF 2019), 18 - 21 June 2019
DOI: 10.5075/epfl-iclab-icnf-269309