Development of New therapies against cholangiopathies.

Project Information

New Chol

Grant agreement ID: 741707

DOI 10.3030/741707

Project closed

EC signature date 29 November 2017

Start date 1 December 2017

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 111,00

EU contribution € 2 499 111,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

Publications

Peer reviewed articles (17)

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency

Author(s): Charis-Patricia Segeritz, Sheikh Tamir Rashid, Miguel Cardoso de Brito, Maria Paola Serra, Adriana Ordonez, Carola Maria Morell, Joseph E. Kaserman, Pedro Madrigal, Nicholas R.F. Hannan, Laurent Gatto, Lu Tan, Andrew A. Wilson, Kathryn Lilley, Stefan J. Marciniak, Bibek Gooptu, David A. Lomas, Ludovic Vallier
Published in: Journal of Hepatology, Issue 69/4, 2018, Page(s) 851-860, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.028

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Author(s): Natasha Hui Jin Ng, Joanita Binte Jasmen, Chang Siang Lim, Hwee Hui Lau, Vidhya Gomathi Krishnan, Juned Kadiwala, Rohit N. Kulkarni, Helge Ræder, Ludovic Vallier, Shawn Hoon, Adrian Kee Keong Teo
Published in: iScience, Issue 16, 2019, Page(s) 192-205, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2019.05.032

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

Author(s): Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Published in: Genome Biology, Issue 20/1, 2019, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-019-1644-0

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue

Author(s): Olivia C. Tysoe, Alexander W. Justin, Teresa Brevini, Si Emma Chen, Krishnaa T. Mahbubani, Anna K. Frank, Hajer Zedira, Espen Melum, Kourosh Saeb-Parsy, Athina E. Markaki, Ludovic Vallier, Fotios Sampaziotis
Published in: Nature Protocols, Issue 14/6, 2019, Page(s) 1884-1925, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0168-0

Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell–Derived Intestinal Epithelial Organoids

Author(s): Judith Kraiczy, Alexander D.B. Ross, Jessica L. Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 7/2, 2019, Page(s) 285-288, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2018.10.008

Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics

Author(s): Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Published in: Stem Cell Reports, Issue 12/1, 2019, Page(s) 165-179, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.11.020

Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications

Author(s): Loukia Yiangou, Alexander D.B. Ross, Kim Jee Goh, Ludovic Vallier
Published in: Cell Stem Cell, Issue 22/4, 2018, Page(s) 485-499, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.03.016

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells‐derived hepatic stem cells

Author(s): Angélique Fourrier, Frédéric Delbos, Séverine Menoret, Camille Collet, Linh Trinh Thi Thuy, Anne Myara, François Petit, Laia Tolosa, Sophie Laplanche, María José Gómez‐Lechón, Philippe Labrune, Ignacio Anegon, Ludovic Vallier, Delphine Garnier, Tuan Huy Nguyen
Published in: Xenotransplantation, 2019, ISSN 0908-665X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/xen.12544

Advances in the generation of bioengineered bile ducts

Author(s): Alexander W. Justin, Kourosh Saeb-Parsy, Athina E. Markaki, Ludovic Vallier, Fotios Sampaziotis
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1864/4, 2018, Page(s) 1532-1538, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2017.10.034

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

Author(s): Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C. Hubner, Igor Ruiz de los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G. Stunnenberg, Sasha Mendjan, Ludovic Vallier
Published in: Nature, Issue 555/7695, 2018, Page(s) 256-259, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature25784

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Author(s): Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14457-z

A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei

Author(s): Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C. Skarnes, Maria M. Mota, Oliver Billker
Published in: Stem Cell Reports, Issue 14/6, 2020, Page(s) 1123-1134, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.04.010

GDF15 mediates the effects of metformin on body weight and energy balance

Author(s): Anthony P. Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A. Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A. Goldspink, Emily L. Miedzybrodzka, Adam R. Konopka, Raul Ruiz Esponda, Jeffrey T.-J. Huang, Y. C. Loraine Tung, Sergio Rodriguez-Cuenca, Rute A. Tomaz, Heather P. Harding, Audrey Melvin, Giles S. H. Yeo, David Preiss, Antonio Vidal-Puig, Lud
Published in: Nature, Issue 578/7795, 2020, Page(s) 444-448, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1911-y

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Author(s): Waradon Sungnak, Ni Huang, Christophe Bécavin, Marijn Berg, Rachel Queen, Monika Litvinukova, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Fotios Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, Josephine L. Barnes
Published in: Nature Medicine, Issue 26/5, 2020, Page(s) 681-687, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-0868-6

Regional differences in human biliary tissues and corresponding in vitro derived organoids

Author(s): Casey A Rimland, Samantha G Tilson, Carola M Morell, Rute A Tomaz, Wei-Yu Lu, Simone E Adams, Nikitas Georgakopoulos, Francisco Otaizo-Carrasquero, Timothy G Myers, John R Ferdinand, Richard L Gieseck, Fotios Sampaziotis, Olivia C Tysoe, Brandon Wesley, Daniele Muraro, Gabriel C Oniscu, Nicholas RF Hannan, Stuart J Forbes, Kourosh Saeb-Parsy, Thomas A Wynn, Ludovic Vallier
Published in: Hepatology, 2020, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31252

Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation

Author(s): Giovanni Canu, Emmanouil Athanasiadis, Rodrigo A. Grandy, Jose Garcia-Bernardo, Paulina M. Strzelecka, Ludovic Vallier, Daniel Ortmann, Ana Cvejic
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/s13059-020-02058-4

Cell cycle regulators control mesoderm specification in human pluripotent stem cells

Author(s): Loukia Yiangou, Rodrigo A. Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier
Published in: Journal of Biological Chemistry, Issue 294/47, 2019, Page(s) 17903-17914, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008251

Non-peer reviewed articles (1)

Modeling Disease with Human Inducible Pluripotent Stem Cells

Author(s): Rodrigo Grandy, Rute A. Tomaz, Ludovic Vallier
Published in: Annual Review of Pathology: Mechanisms of Disease, Issue 14/1, 2019, Page(s) 449-468, ISSN 1553-4006
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathol-020117-043634

Book chapters (1)

Use of Biliary Organoids in Cholestasis Research

Author(s): Fotios Sampaziotis, Olivia Tysoe, Teresa Brevini, Ludovic Vallier
Published in: Experimental Cholestasis Research, Issue 1981, 2019, Page(s) 373-382, ISBN 978-1-4939-9419-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-9420-5_25