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Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Obiettivo

Recent evidence demonstrates that cancer is overtaking cardiovascular disease as the number one cause of mortality in Europe. This is largely due to the lack of preventative measures for common (e.g. breast) or highly fatal (e.g. ovarian) human cancers. Most cancers are multifactorial in origin. The core hypothesis of this research programme is that the extremely high risk of BRCA1/2 germline mutation carriers to develop breast and ovarian cancer is a net consequence of cell-autonomous (direct effect of BRCA mutation in cells at risk) and cell non-autonomous (produced in distant organs and affecting organs at risk) factors which both trigger epigenetic, cancer-initiating effects.
The project’s aims are centered around the principles of systems medicine and built on a large cohort of BRCA mutation carriers and controls who will be offered newly established cancer screening programmes. We will uncover how ‘cell non-autonomous’ factors work, provide detail on the epigenetic changes in at-risk tissues and investigate whether these changes are mechanistically linked to cancer, study whether we can neutralise this process and measure success in the organs at risk, and ideally in easy to access samples such as blood, buccal and cervical cells.
In my Department for Women’s Cancer we have assembled a powerful interdisciplinary team including computational biologists, functionalists, immunologists and clinician scientists linked to leading patient advocacy groups which is extremely well placed to lead this pioneering project to develop the fundamental understanding of cancer development in women with BRCA mutations. To reset the epigenome, re-establishing normal cell identity and consequently reducing cancer risk without the need for surgery and being able to monitor the efficacy using multicellular epigenetic outcome predictors will be a major scientific and medical breakthrough and possibly applicable to other chronic diseases.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

ERC-2016-ADG

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Meccanismo di finanziamento

ERC-ADG - Advanced Grant

Coordinatore

UNIVERSITAET INNSBRUCK
Contribution nette de l'UE
€ 1 115 793,00
Indirizzo
Innrain 52
6020 Innsbruck
Austria

Mostra sulla mappa
Regione
Westösterreich Tirol Innsbruck
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Altri finanziamenti
€ 0,00

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Ultimo aggiornamento: 21 Settembre 2023

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Permalink: https://cordis.europa.eu/project/id/742432/it

European Union, 2023