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Tailored chemical complexity through evolution-inspired synthetic biology

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A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Author(s): Michael Rust; Eric J. N. Helfrich; Michael F. Freeman; Pakjira Nanudorn; Christopher M. Field; Christian Rückert; Tomas Kündig; Michael J. Page; Victoria L. Webb; Jörn Kalinowski; Shinichi Sunagawa; Jörn Piel
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 2, 2020, ISSN 0027-8424
DOI: 10.3929/ethz-b-000413997

Genome Mining of Oxidation Modules in trans ‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

Author(s): Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel
Published in: Angewandte Chemie International Edition, Issue 59/20, 2020, Page(s) 7761-7765, ISSN 1433-7851
DOI: 10.1002/anie.201916005

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

Author(s): Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel
Published in: Angewandte Chemie International Edition, Issue 57/36, 2018, Page(s) 11644-11648, ISSN 1433-7851
DOI: 10.1002/anie.201805363

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

Author(s): Eric J. N. Helfrich, Christine M. Vogel, Reiko Ueoka, Martin Schäfer, Florian Ryffel, Daniel B. Müller, Silke Probst, Markus Kreuzer, Jörn Piel, Julia A. Vorholt
Published in: Nature Microbiology, Issue 3/8, 2018, Page(s) 909-919, ISSN 2058-5276
DOI: 10.1038/s41564-018-0200-0

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Author(s): Brandon I. Morinaka, Edgars Lakis, Marjan Verest, Maximilian J. Helf, Thibault Scalvenzi, Anna L. Vagstad, James Sims, Shinichi Sunagawa, Muriel Gugger, Jörn Piel
Published in: Science, Issue 359/6377, 2018, Page(s) 779-782, ISSN 0036-8075
DOI: 10.1126/science.aao0157

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

Author(s): Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel
Published in: Angewandte Chemie International Edition, Issue 57/44, 2018, Page(s) 14519-14523, ISSN 1433-7851
DOI: 10.1002/anie.201805673

Structural and Functional Studies of a Pyran Synthase Domain from a trans -Acyltransferase Assembly Line

Author(s): Drew T. Wagner, Zhicheng Zhang, Roy A. Meoded, Alexis J. Cepeda, Jörn Piel, Adrian T. Keatinge-Clay
Published in: ACS Chemical Biology, Issue 13/4, 2018, Page(s) 975-983, ISSN 1554-8929
DOI: 10.1021/acschembio.8b00049

Opening up the Single-Cell Toolbox for Microbial Natural Products Research

Author(s): Jörn Piel, Jackson Cahn
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
DOI: 10.1002/anie.201900532

Automated structure prediction of trans-acyltransferase polyketide synthase products

Author(s): Eric J. N. Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel
Published in: Nature Chemical Biology, Issue 15/8, 2019, Page(s) 813-821, ISSN 1552-4450
DOI: 10.1038/s41589-019-0313-7

Effect of tolytoxin on tunneling nanotube formation and function

Author(s): Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger, Chiara Zurzolo
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-42161-6

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Author(s): Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman, Jörn Piel
Published in: Nature Chemistry, Issue 11/10, 2019, Page(s) 931-939, ISSN 1755-4330
DOI: 10.1038/s41557-019-0323-9

The hidden enzymology of bacterial natural product biosynthesis

Author(s): Thomas A. Scott, Jörn Piel
Published in: Nature Reviews Chemistry, Issue 3/7, 2019, Page(s) 404-425, ISSN 2397-3358
DOI: 10.1038/s41570-019-0107-1