Tailored chemical complexity through evolution-inspired synthetic biology

Publicaciones

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Autores: Michael Rust; Eric J. N. Helfrich; Michael F. Freeman; Pakjira Nanudorn; Christopher M. Field; Christian Rückert; Tomas Kündig; Michael J. Page; Victoria L. Webb; Jörn Kalinowski; Shinichi Sunagawa; Jörn Piel
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, Edición 2, 2020, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.3929/ethz-b-000413997

Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

Autores: Dr. Franziska Hemmerling,Dr. Roy A. Meoded,Dr. Amy E. Fraley,Hannah A. Minas,Cora L. Dieterich,Dr. Michael Rust,Dr. Reiko Ueoka,Dr. Katja Jensen,Prof. Dr. Eric J. N. Helfrich,Cedric Bergande,Maurice Biedermann,Dr. Nancy Magnus,Prof. Dr. Birgit Piechulla, Prof. Jörn Piel
Publicado en: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202116614

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids.

Autores: Atsushi Nakabachi; Jörn Piel; Igor Malenovský; Yuu Hirose
Publicado en: Genome Biology and Evolution, Edición 17596653, 2020, Página(s) 1975–1987, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.3929/ethz-b-000451415

In Vivo Production of Diverse beta-Amino Acid-Containing Proteins

Autores: Edgars Lakis; Sarolt Magyari; Jörn Piel
Publicado en: Angewandte Chemie. International Edition, 61 (29), Edición 14337851, 2022, Página(s) e202202695, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202202695

Toblerols, Cyclopropanol-Containing Modulators of Methylobacterial Antibiosis Generated by an Unusual Polyketide Synthase

Autores: Ueoka, Reiko Bortfeld-Miller, Miriam Morinaka, Brandon I. Vorholt, Julia A. Piel, Jörn
Publicado en: Angewandte Chemie (international Edition), 2017, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709056

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

Autores: Reiko Ueoka, Philipp Sondermann, Stefan Leopold-Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R. Thomas Williamson, Erick M. Carreira, Jörn Piel
Publicado en: Nature Chemistry, Edición 17554330, 2022, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-022-01020-0

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

Autores: Li Su, Laurence Hôtel, Cédric Paris, Clara Chepkirui, Alexander O Brachmann, Jörn Piel, Christophe Jacob, Bertrand Aigle, Kira J Weissman
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-27955-z

Opening up the Single‐Cell Toolbox for Microbial Natural Products Research

Autores: Jackson K. B. Cahn; Jörn Piel
Publicado en: Angewandte Chemie International Edition, Edición 14337851, 2021, Página(s) 18412-18428, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900532

Genome Mining of Oxidation Modules in trans ‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

Autores: Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel
Publicado en: Angewandte Chemie International Edition, Edición 59/20, 2020, Página(s) 7761-7765, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916005

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

Autores: Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel
Publicado en: Angewandte Chemie International Edition, Edición 57/36, 2018, Página(s) 11644-11648, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805363

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

Autores: Eric J. N. Helfrich, Christine M. Vogel, Reiko Ueoka, Martin Schäfer, Florian Ryffel, Daniel B. Müller, Silke Probst, Markus Kreuzer, Jörn Piel, Julia A. Vorholt
Publicado en: Nature Microbiology, Edición 3/8, 2018, Página(s) 909-919, ISSN 2058-5276
Editor: Nature Research
DOI: 10.1038/s41564-018-0200-0

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Autores: Brandon I. Morinaka, Edgars Lakis, Marjan Verest, Maximilian J. Helf, Thibault Scalvenzi, Anna L. Vagstad, James Sims, Shinichi Sunagawa, Muriel Gugger, Jörn Piel
Publicado en: Science, Edición 359/6377, 2018, Página(s) 779-782, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aao0157

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

Autores: Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel
Publicado en: Angewandte Chemie International Edition, Edición 57/44, 2018, Página(s) 14519-14523, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805673

Structural and Functional Studies of a Pyran Synthase Domain from a trans -Acyltransferase Assembly Line

Autores: Drew T. Wagner, Zhicheng Zhang, Roy A. Meoded, Alexis J. Cepeda, Jörn Piel, Adrian T. Keatinge-Clay
Publicado en: ACS Chemical Biology, Edición 13/4, 2018, Página(s) 975-983, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.8b00049

Automated structure prediction of trans-acyltransferase polyketide synthase products

Autores: Eric J. N. Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel
Publicado en: Nature Chemical Biology, Edición 15/8, 2019, Página(s) 813-821, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-019-0313-7

Effect of tolytoxin on tunneling nanotube formation and function

Autores: Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger, Chiara Zurzolo
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-42161-6

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Autores: Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman, Jörn Piel
Publicado en: Nature Chemistry, Edición 11/10, 2019, Página(s) 931-939, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-019-0323-9

The hidden enzymology of bacterial natural product biosynthesis

Autores: Thomas A. Scott, Jörn Piel
Publicado en: Nature Reviews Chemistry, Edición 3/7, 2019, Página(s) 404-425, ISSN 2397-3358
Editor: Nature Research
DOI: 10.1038/s41570-019-0107-1

Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis

Autores: Amy E. Fraley, Cora L. Dieterich, Mathijs F. J. Mabesoone, Hannah A. Minas, Roy A Meoded, Franziska Hemmerling, Jörn Piel
Publicado en: Angewandte Chemie International Edition, Edición 14337851, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206385

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Autores: Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel & Marnix H. Medema
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-21163-x

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Autores: Franziska Hemmerling; Jörn Piel
Publicado en: Nature Reviews Drug Discovery, 21 (5), Edición 14741776, 2022, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/s41573-022-00414-6

Derechos de propiedad intelectual

USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES

Número de solicitud/publicación: 20 18050225
Fecha: 2018-01-05

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