Tailored chemical complexity through evolution-inspired synthetic biology

Informazioni relative al progetto

SynPlex

ID dell’accordo di sovvenzione: 742739

DOI

10.3030/742739

Progetto chiuso

Data della firma CE 19 Maggio 2017

Data di avvio 1 Agosto 2017

Data di completamento 31 Luglio 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 495 755,00

Contributo UE

€ 2 495 755,00

Coordinato da

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Autori: Michael Rust; Eric J. N. Helfrich; Michael F. Freeman; Pakjira Nanudorn; Christopher M. Field; Christian Rückert; Tomas Kündig; Michael J. Page; Victoria L. Webb; Jörn Kalinowski; Shinichi Sunagawa; Jörn Piel
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, Numero 2, 2020, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.3929/ethz-b-000413997

Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

Autori: Dr. Franziska Hemmerling,Dr. Roy A. Meoded,Dr. Amy E. Fraley,Hannah A. Minas,Cora L. Dieterich,Dr. Michael Rust,Dr. Reiko Ueoka,Dr. Katja Jensen,Prof. Dr. Eric J. N. Helfrich,Cedric Bergande,Maurice Biedermann,Dr. Nancy Magnus,Prof. Dr. Birgit Piechulla, Prof. Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202116614

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids.

Autori: Atsushi Nakabachi; Jörn Piel; Igor Malenovský; Yuu Hirose
Pubblicato in: Genome Biology and Evolution, Numero 1, 2020, Pagina/e 1975–1987, ISSN 1759-6653
Editore: Oxford University Press
DOI: 10.3929/ethz-b-000451415

In Vivo Production of Diverse beta-Amino Acid-Containing Proteins

Autori: Edgars Lakis; Sarolt Magyari; Jörn Piel
Pubblicato in: Angewandte Chemie. International Edition, 61 (29), Numero 3, 2022, Pagina/e e202202695, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202202695

Toblerols, Cyclopropanol-Containing Modulators of Methylobacterial Antibiosis Generated by an Unusual Polyketide Synthase

Autori: Ueoka, Reiko Bortfeld-Miller, Miriam Morinaka, Brandon I. Vorholt, Julia A. Piel, Jörn
Pubblicato in: Angewandte Chemie (international Edition), 2017, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709056

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

Autori: Reiko Ueoka, Philipp Sondermann, Stefan Leopold-Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R. Thomas Williamson, Erick M. Carreira, Jörn Piel
Pubblicato in: Nature Chemistry, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-01020-0

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

Autori: Li Su, Laurence Hôtel, Cédric Paris, Clara Chepkirui, Alexander O Brachmann, Jörn Piel, Christophe Jacob, Bertrand Aigle, Kira J Weissman
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-27955-z

Opening up the Single‐Cell Toolbox for Microbial Natural Products Research

Autori: Jackson K. B. Cahn; Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, Numero 4, 2021, Pagina/e 18412-18428, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900532

Genome Mining of Oxidation Modules in trans ‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

Autori: Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, Numero 59/20, 2020, Pagina/e 7761-7765, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916005

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

Autori: Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, Numero 57/36, 2018, Pagina/e 11644-11648, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805363

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

Autori: Eric J. N. Helfrich, Christine M. Vogel, Reiko Ueoka, Martin Schäfer, Florian Ryffel, Daniel B. Müller, Silke Probst, Markus Kreuzer, Jörn Piel, Julia A. Vorholt
Pubblicato in: Nature Microbiology, Numero 3/8, 2018, Pagina/e 909-919, ISSN 2058-5276
Editore: Nature Research
DOI: 10.1038/s41564-018-0200-0

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Autori: Brandon I. Morinaka, Edgars Lakis, Marjan Verest, Maximilian J. Helf, Thibault Scalvenzi, Anna L. Vagstad, James Sims, Shinichi Sunagawa, Muriel Gugger, Jörn Piel
Pubblicato in: Science, Numero 359/6377, 2018, Pagina/e 779-782, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aao0157

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

Autori: Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, Numero 57/44, 2018, Pagina/e 14519-14523, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805673

Structural and Functional Studies of a Pyran Synthase Domain from a trans -Acyltransferase Assembly Line

Autori: Drew T. Wagner, Zhicheng Zhang, Roy A. Meoded, Alexis J. Cepeda, Jörn Piel, Adrian T. Keatinge-Clay
Pubblicato in: ACS Chemical Biology, Numero 13/4, 2018, Pagina/e 975-983, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b00049

Automated structure prediction of trans-acyltransferase polyketide synthase products

Autori: Eric J. N. Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel
Pubblicato in: Nature Chemical Biology, Numero 15/8, 2019, Pagina/e 813-821, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-019-0313-7

Effect of tolytoxin on tunneling nanotube formation and function

Autori: Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger, Chiara Zurzolo
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-42161-6

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Autori: Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman, Jörn Piel
Pubblicato in: Nature Chemistry, Numero 11/10, 2019, Pagina/e 931-939, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-019-0323-9

The hidden enzymology of bacterial natural product biosynthesis

Autori: Thomas A. Scott, Jörn Piel
Pubblicato in: Nature Reviews Chemistry, Numero 3/7, 2019, Pagina/e 404-425, ISSN 2397-3358
Editore: Nature Research
DOI: 10.1038/s41570-019-0107-1

Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis

Autori: Amy E. Fraley, Cora L. Dieterich, Mathijs F. J. Mabesoone, Hannah A. Minas, Roy A Meoded, Franziska Hemmerling, Jörn Piel
Pubblicato in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206385

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Autori: Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel & Marnix H. Medema
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21163-x

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Autori: Franziska Hemmerling; Jörn Piel
Pubblicato in: Nature Reviews Drug Discovery, 21 (5), Numero 2, 2022, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-022-00414-6

Diritti di proprietà intellettuale

Patent (1)

USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES

Numero candidatura/pubblicazione: 20 18050225
Data: 2018-01-05
Candidato/i: EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH