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Tailored chemical complexity through evolution-inspired synthetic biology

Publikacje

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Autorzy: Michael Rust; Eric J. N. Helfrich; Michael F. Freeman; Pakjira Nanudorn; Christopher M. Field; Christian Rückert; Tomas Kündig; Michael J. Page; Victoria L. Webb; Jörn Kalinowski; Shinichi Sunagawa; Jörn Piel
Opublikowane w: Proceedings of the National Academy of Sciences of the United States of America, Numer 2, 2020, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.3929/ethz-b-000413997

Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

Autorzy: Dr. Franziska Hemmerling,Dr. Roy A. Meoded,Dr. Amy E. Fraley,Hannah A. Minas,Cora L. Dieterich,Dr. Michael Rust,Dr. Reiko Ueoka,Dr. Katja Jensen,Prof. Dr. Eric J. N. Helfrich,Cedric Bergande,Maurice Biedermann,Dr. Nancy Magnus,Prof. Dr. Birgit Piechulla, Prof. Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202116614

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids.

Autorzy: Atsushi Nakabachi; Jörn Piel; Igor Malenovský; Yuu Hirose
Opublikowane w: Genome Biology and Evolution, Numer 17596653, 2020, Strona(/y) 1975–1987, ISSN 1759-6653
Wydawca: Oxford University Press
DOI: 10.3929/ethz-b-000451415

In Vivo Production of Diverse beta-Amino Acid-Containing Proteins

Autorzy: Edgars Lakis; Sarolt Magyari; Jörn Piel
Opublikowane w: Angewandte Chemie. International Edition, 61 (29), Numer 14337851, 2022, Strona(/y) e202202695, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202202695

Toblerols, Cyclopropanol-Containing Modulators of Methylobacterial Antibiosis Generated by an Unusual Polyketide Synthase

Autorzy: Ueoka, Reiko Bortfeld-Miller, Miriam Morinaka, Brandon I. Vorholt, Julia A. Piel, Jörn
Opublikowane w: Angewandte Chemie (international Edition), 2017, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709056

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

Autorzy: Reiko Ueoka, Philipp Sondermann, Stefan Leopold-Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R. Thomas Williamson, Erick M. Carreira, Jörn Piel
Opublikowane w: Nature Chemistry, Numer 17554330, 2022, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-022-01020-0

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

Autorzy: Li Su, Laurence Hôtel, Cédric Paris, Clara Chepkirui, Alexander O Brachmann, Jörn Piel, Christophe Jacob, Bertrand Aigle, Kira J Weissman
Opublikowane w: Nature Communications, Numer 20411723, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-27955-z

Opening up the Single‐Cell Toolbox for Microbial Natural Products Research

Autorzy: Jackson K. B. Cahn; Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, Numer 14337851, 2021, Strona(/y) 18412-18428, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900532

Genome Mining of Oxidation Modules in trans ‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

Autorzy: Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, Numer 59/20, 2020, Strona(/y) 7761-7765, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916005

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

Autorzy: Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, Numer 57/36, 2018, Strona(/y) 11644-11648, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805363

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

Autorzy: Eric J. N. Helfrich, Christine M. Vogel, Reiko Ueoka, Martin Schäfer, Florian Ryffel, Daniel B. Müller, Silke Probst, Markus Kreuzer, Jörn Piel, Julia A. Vorholt
Opublikowane w: Nature Microbiology, Numer 3/8, 2018, Strona(/y) 909-919, ISSN 2058-5276
Wydawca: Nature Research
DOI: 10.1038/s41564-018-0200-0

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Autorzy: Brandon I. Morinaka, Edgars Lakis, Marjan Verest, Maximilian J. Helf, Thibault Scalvenzi, Anna L. Vagstad, James Sims, Shinichi Sunagawa, Muriel Gugger, Jörn Piel
Opublikowane w: Science, Numer 359/6377, 2018, Strona(/y) 779-782, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aao0157

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

Autorzy: Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, Numer 57/44, 2018, Strona(/y) 14519-14523, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201805673

Structural and Functional Studies of a Pyran Synthase Domain from a trans -Acyltransferase Assembly Line

Autorzy: Drew T. Wagner, Zhicheng Zhang, Roy A. Meoded, Alexis J. Cepeda, Jörn Piel, Adrian T. Keatinge-Clay
Opublikowane w: ACS Chemical Biology, Numer 13/4, 2018, Strona(/y) 975-983, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.8b00049

Automated structure prediction of trans-acyltransferase polyketide synthase products

Autorzy: Eric J. N. Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel
Opublikowane w: Nature Chemical Biology, Numer 15/8, 2019, Strona(/y) 813-821, ISSN 1552-4450
Wydawca: Nature Publishing Group
DOI: 10.1038/s41589-019-0313-7

Effect of tolytoxin on tunneling nanotube formation and function

Autorzy: Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger, Chiara Zurzolo
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-42161-6

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Autorzy: Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman, Jörn Piel
Opublikowane w: Nature Chemistry, Numer 11/10, 2019, Strona(/y) 931-939, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-019-0323-9

The hidden enzymology of bacterial natural product biosynthesis

Autorzy: Thomas A. Scott, Jörn Piel
Opublikowane w: Nature Reviews Chemistry, Numer 3/7, 2019, Strona(/y) 404-425, ISSN 2397-3358
Wydawca: Nature Research
DOI: 10.1038/s41570-019-0107-1

Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis

Autorzy: Amy E. Fraley, Cora L. Dieterich, Mathijs F. J. Mabesoone, Hannah A. Minas, Roy A Meoded, Franziska Hemmerling, Jörn Piel
Opublikowane w: Angewandte Chemie International Edition, Numer 14337851, 2022, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206385

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Autorzy: Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel & Marnix H. Medema
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-21163-x

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Autorzy: Franziska Hemmerling; Jörn Piel
Opublikowane w: Nature Reviews Drug Discovery, 21 (5), Numer 14741776, 2022, ISSN 1474-1776
Wydawca: Nature Publishing Group
DOI: 10.1038/s41573-022-00414-6

Prawa własności intelektualnej

USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES

Numer wniosku/publikacji: 20 18050225
Data: 2018-01-05

USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES

Numer wniosku/publikacji: 20 18050225
Data: 2018-01-05

USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES

Numer wniosku/publikacji: 20 18050225
Data: 2018-01-05

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