Dynamic control of assembly, directonnality and chirality in hydrogen bond networks.

Projektinformationen

DYNASSEMBLY

ID Finanzhilfevereinbarung: 745476

DOI

10.3030/745476

Das Projekt endete am 9 Oktober 2018

EK-Unterschriftsdatum 9 Oktober 2017

Startdatum 1 Januar 2018

Enddatum 31 Dezember 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 183 454,80

EU-Beitrag

€ 183 454,80

Koordiniert durch

UNIVERSITY OF BRISTOL
United Kingdom

Periodic Reporting for period 1 - DYNASSEMBLY (Dynamic control of assembly, directonnality and chirality in hydrogen bond networks.)

Berichtszeitraum: 2018-01-01 bis 2019-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

By combining biology's information storage and replication strategies, namely specific hydrogen-bonding between nucleobases, with the potential for hydrogen-bond reorganisation in supramolecular systems, we propose to develop a new, artificial but bio-inspired mechanism for the transfer of information. We aimed to build molecular assemblies which spontaneously associate and fold in solution, forming intramolecular polarized hydrogen-bond networks. By addition of simple chemical additives forming competitive intermolecular hydrogen bonds with the foldamer, the directionality of these networks will be modified, transforming a conformational mixture to a well-defined unidirectional network. Molecular events such as reversible switching, chemical sensing, and long-distance information communication will be studied in 3D hydrogen bond networks, with to the overall objective of making highly functionalised, well-defined responsive macromolecular arrays ‘bottom-up’. Structures that give a non-spectroscopic 'readout' of the interaction with the additive will be built, which for example exhibit 'off-on' fluorescence or 'off-on' catalytic activity. The application of these foldamers in the construction of photochemically switchable molecular devices will be investigated. The work will contribute to the development of new nano-scale functionality that could impact on the way that medical devices or other interactive modules function at a molecular level.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The project started by building molecules that can interact and communicate in solution, with the aim of sending messages in the form of light-initiated acidity changes. Initial synthetic know-how was obtained that will facilitate future development of the area, and will ultimately be disseminated once downstream projects making use of the technology reach maturity.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

New structures were built that will underpin future developments, but the short timescale of the project meant that advances were limited. Future impacts will become evident when these results are used to underpin further developments.

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