Dynamic control of assembly, directonnality and chirality in hydrogen bond networks.

Informazioni relative al progetto

DYNASSEMBLY

ID dell’accordo di sovvenzione: 745476

DOI

10.3030/745476

Progetto concluso il 9 Ottobre 2018

Data della firma CE 9 Ottobre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 31 Dicembre 2019

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 183 454,80

Contributo UE

€ 183 454,80

Coordinato da

UNIVERSITY OF BRISTOL
United Kingdom

Periodic Reporting for period 1 - DYNASSEMBLY (Dynamic control of assembly, directonnality and chirality in hydrogen bond networks.)

Periodo di rendicontazione: 2018-01-01 al 2019-12-31

Sintesi del contesto e degli obiettivi generali del progetto

By combining biology's information storage and replication strategies, namely specific hydrogen-bonding between nucleobases, with the potential for hydrogen-bond reorganisation in supramolecular systems, we propose to develop a new, artificial but bio-inspired mechanism for the transfer of information. We aimed to build molecular assemblies which spontaneously associate and fold in solution, forming intramolecular polarized hydrogen-bond networks. By addition of simple chemical additives forming competitive intermolecular hydrogen bonds with the foldamer, the directionality of these networks will be modified, transforming a conformational mixture to a well-defined unidirectional network. Molecular events such as reversible switching, chemical sensing, and long-distance information communication will be studied in 3D hydrogen bond networks, with to the overall objective of making highly functionalised, well-defined responsive macromolecular arrays ‘bottom-up’. Structures that give a non-spectroscopic 'readout' of the interaction with the additive will be built, which for example exhibit 'off-on' fluorescence or 'off-on' catalytic activity. The application of these foldamers in the construction of photochemically switchable molecular devices will be investigated. The work will contribute to the development of new nano-scale functionality that could impact on the way that medical devices or other interactive modules function at a molecular level.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

The project started by building molecules that can interact and communicate in solution, with the aim of sending messages in the form of light-initiated acidity changes. Initial synthetic know-how was obtained that will facilitate future development of the area, and will ultimately be disseminated once downstream projects making use of the technology reach maturity.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

New structures were built that will underpin future developments, but the short timescale of the project meant that advances were limited. Future impacts will become evident when these results are used to underpin further developments.

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