Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy

Project Information

METCLL

Grant agreement ID: 750345

DOI 10.3030/750345

Project terminated on 1 October 2020

EC signature date 20 March 2017

Start date 1 September 2018

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 264 668,40

EU contribution € 264 668,40

Coordinated by

INSTITUT CURIE
France

Publications

Peer reviewed articles (4)

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Author(s): Franco Izzo, Stanley C. Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil D. Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S. Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C. Schulman, Michelle Ki, Priscillia Lhoumaud, Jane A. Skok, Aaron D. Viny, Ross L. Levine, Ephraim Kenigsberg, Omar Abdel-Wahab, Dan A. Landau
Published in: Nature Genetics, Issue 52/4, 2020, Page(s) 378-387, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0595-4

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

Author(s): Federico Gaiti, Ronan Chaligne, Hongcang Gu, Ryan M. Brand, Steven Kothen-Hill, Rafael C. Schulman, Kirill Grigorev, Davide Risso, Kyu-Tae Kim, Alessandro Pastore, Kevin Y. Huang, Alicia Alonso, Caroline Sheridan, Nathaniel D. Omans, Evan Biederstedt, Kendell Clement, Lili Wang, Joshua A. Felsenfeld, Erica B. Bhavsar, Martin J. Aryee, John N. Allan, Richard Furman, Andreas Gnirke, Catherine J. Wu,
Published in: Nature, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1198-z

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

Author(s): Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Jiang, Rafael C. Schulman, Kyu-Tae Kim, Alicia Alonso, John N. Allan, Richard R. Furman, Andreas Gnirke, Catherine J. Wu, Ari M. Melnick, Alexander Meissner, Bradley E. Bernstein, Omar Abdel-Wahab, Dan A. Landau
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09645-5

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Author(s): Anna S. Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Justin Taylor, Robert M. Myers, Ghaith Abu-Zeinah, Ryan Brand, Nathaniel D. Omans, Alicia Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, Eoghan Harrington, Alessandro Pastore, Juan R. Cubillos-Ruiz, Wayne Tam, Ronald Hoffman, Raul Rabadan, Joseph M. Scandura, Omar Abdel-Wahab, Peter Smibert, Dan A. Landau
Published in: Nature, Issue 571/7765, 2019, Page(s) 355-360, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1367-0

Non-peer reviewed articles (1)

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Author(s): Anna S. Nam, Ronan Chaligne, Dan A. Landau
Published in: Nature Reviews Genetics, 2020, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-020-0265-5