Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy

Informazioni relative al progetto

METCLL

ID dell’accordo di sovvenzione: 750345

DOI 10.3030/750345

Progetto concluso il 1 Ottobre 2020

Data della firma CE 20 Marzo 2017

Data di avvio 1 Settembre 2018

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 264 668,40

Contributo UE € 264 668,40

Coordinato da

INSTITUT CURIE
France

Pubblicazioni

Peer reviewed articles (4)

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Autori: Franco Izzo, Stanley C. Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil D. Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S. Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C. Schulman, Michelle Ki, Priscillia Lhoumaud, Jane A. Skok, Aaron D. Viny, Ross L. Levine, Ephraim Kenigsberg, Omar Abdel-Wahab, Dan A. Landau
Pubblicato in: Nature Genetics, Numero 52/4, 2020, Pagina/e 378-387, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-020-0595-4

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

Autori: Federico Gaiti, Ronan Chaligne, Hongcang Gu, Ryan M. Brand, Steven Kothen-Hill, Rafael C. Schulman, Kirill Grigorev, Davide Risso, Kyu-Tae Kim, Alessandro Pastore, Kevin Y. Huang, Alicia Alonso, Caroline Sheridan, Nathaniel D. Omans, Evan Biederstedt, Kendell Clement, Lili Wang, Joshua A. Felsenfeld, Erica B. Bhavsar, Martin J. Aryee, John N. Allan, Richard Furman, Andreas Gnirke, Catherine J. Wu,
Pubblicato in: Nature, 2019, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1198-z

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

Autori: Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Jiang, Rafael C. Schulman, Kyu-Tae Kim, Alicia Alonso, John N. Allan, Richard R. Furman, Andreas Gnirke, Catherine J. Wu, Ari M. Melnick, Alexander Meissner, Bradley E. Bernstein, Omar Abdel-Wahab, Dan A. Landau
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09645-5

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Autori: Anna S. Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Justin Taylor, Robert M. Myers, Ghaith Abu-Zeinah, Ryan Brand, Nathaniel D. Omans, Alicia Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, Eoghan Harrington, Alessandro Pastore, Juan R. Cubillos-Ruiz, Wayne Tam, Ronald Hoffman, Raul Rabadan, Joseph M. Scandura, Omar Abdel-Wahab, Peter Smibert, Dan A. Landau
Pubblicato in: Nature, Numero 571/7765, 2019, Pagina/e 355-360, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1367-0

Non-peer reviewed articles (1)

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Autori: Anna S. Nam, Ronan Chaligne, Dan A. Landau
Pubblicato in: Nature Reviews Genetics, 2020, ISSN 1471-0056
Editore: Nature Publishing Group
DOI: 10.1038/s41576-020-0265-5