Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy

Publicaciones

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Autores: Franco Izzo, Stanley C. Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil D. Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S. Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C. Schulman, Michelle Ki, Priscillia Lhoumaud, Jane A. Skok, Aaron D. Viny, Ross L. Levine, Ephraim Kenigsberg, Omar Abdel-Wahab, Dan A. Landau
Publicado en: Nature Genetics, Edición 52/4, 2020, Página(s) 378-387, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-020-0595-4

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

Autores: Federico Gaiti, Ronan Chaligne, Hongcang Gu, Ryan M. Brand, Steven Kothen-Hill, Rafael C. Schulman, Kirill Grigorev, Davide Risso, Kyu-Tae Kim, Alessandro Pastore, Kevin Y. Huang, Alicia Alonso, Caroline Sheridan, Nathaniel D. Omans, Evan Biederstedt, Kendell Clement, Lili Wang, Joshua A. Felsenfeld, Erica B. Bhavsar, Martin J. Aryee, John N. Allan, Richard Furman, Andreas Gnirke, Catherine J. Wu,
Publicado en: Nature, 2019, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1198-z

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

Autores: Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Jiang, Rafael C. Schulman, Kyu-Tae Kim, Alicia Alonso, John N. Allan, Richard R. Furman, Andreas Gnirke, Catherine J. Wu, Ari M. Melnick, Alexander Meissner, Bradley E. Bernstein, Omar Abdel-Wahab, Dan A. Landau
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09645-5

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Autores: Anna S. Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Justin Taylor, Robert M. Myers, Ghaith Abu-Zeinah, Ryan Brand, Nathaniel D. Omans, Alicia Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, Eoghan Harrington, Alessandro Pastore, Juan R. Cubillos-Ruiz, Wayne Tam, Ronald Hoffman, Raul Rabadan, Joseph M. Scandura, Omar Abdel-Wahab, Peter Smibert, Dan A. Landau
Publicado en: Nature, Edición 571/7765, 2019, Página(s) 355-360, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1367-0

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Autores: Anna S. Nam, Ronan Chaligne, Dan A. Landau
Publicado en: Nature Reviews Genetics, 2020, ISSN 1471-0056
Editor: Nature Publishing Group
DOI: 10.1038/s41576-020-0265-5

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