Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification

Project Information

MESI-STRAT

Grant agreement ID: 754688

DOI

10.3030/754688

Project closed

EC signature date 21 November 2017

Start date 1 January 2018

End date 30 September 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 949 963,75

EU contribution

€ 5 949 963,75

Coordinated by

UNIVERSITAET INNSBRUCK
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

MESI-STRAT website with continuous updates

MESI-STRAT website

Documents, reports (1)

WOO trial: Report on status of posting results

WOO trial Report on status of posting results

Publications

Peer reviewed articles (33)

The therapeutic potential of targeting tryptophan catabolism in cancer

Author(s): Christiane A. Opitz, Luis F. Somarribas Patterson, Soumya R. Mohapatra, Dyah L. Dewi, Ahmed Sadik, Michael Platten, Saskia Trump
Published in: British Journal of Cancer, Issue 122/1, 2020, Page(s) 30-44, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-019-0664-6

The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

Author(s): Christiane A. Opitz, Pauline Holfelder, Mirja Tamara Prentzell, Saskia Trump
Published in: Biochemical Pharmacology, Issue 216, October 2023, 2023, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2023.115798

Breaking the Interface: Efficient Extraction of Magnetic Beads from Nanoliter Droplets for Automated Sequential Immunoassays

Author(s): Lukas Metzler; Ulrike Rehbein; Jan-Niklas Schönberg; Thomas Brandstetter; Kathrin Thedieck; Jürgen Rühe
Published in: Analytical Chemistry, Issue 92, 15, 2020, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c00187

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

Author(s): Mathias Bockwoldt, Dorothée Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug, Mathias Ziegler, Ines Heiland
Published in: Proceedings of the National Academy of Sciences, Issue 116/32, 2019, Page(s) 15957-15966, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1902346116

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

Author(s): Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Michael Platten, Ines Heiland, Christiane A. Opitz
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.590532

T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor 1 antibody penetration and improves PD-L1 blocking at the tumor site

Author(s): Pierre-Florent Petit, Raphaële Bombart, Pierre-Hubert Desimple, Stefan Naulaert, Laurie Thouvenel, Jean-François Collet, Benoit Van den Eynde, Jingjing Zhu
Published in: Cancer Immunology Research, Issue Vol. 10, no. 6, 2022, 2022, Page(s) 713 - 727, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0801

Finding new edges: systems approaches to MTOR signaling

Author(s): Alexander Martin Heberle, Ulrike Rehbein, Maria Rodríguez Peiris, Kathrin Thedieck
Published in: Biochemical Society Transactions, Issue 49/1, 2021, Page(s) 41-54, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20190730

Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25

Author(s): Mathias Ziegler, Magnus Monné, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, and Ferdinando Palmieri
Published in: Biomolecules, Issue 11(6), 880, 2021, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11060880

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Author(s): Ahmed Sadik, Luis F. Somarribas Patterson, Selcen Öztürk, Soumya R. Mohapatra, Verena Panitz, Philipp F. Secker, Pauline Pfänder, Stefanie Loth, Heba Salem, Mirja Tamara Prentzell, Bianca Berdel, Murat Iskar, Erik Faessler, Friederike Reuter, Isabelle Kirst, Verena Kalter, Kathrin I. Foerster, Evelyn Jäger, Carina Ramallo Guevara, Mansour Sobeh, Thomas Hielscher, Gernot Poschet, Annekathrin Re
Published in: Cell, Issue 182/5, 2020, Page(s) 1252-1270.e34, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.07.038

Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.

Author(s): Benoît Van den Eynde
Published in: Cancer immunology research, Vol. 9, no.8, p. 854 (2021), 2021, Page(s) 854, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0432

Natural isotope correction improves analysis of protein modification dynamics

Author(s): Jörn Dietze,Alienke van Pijkeren, Anna-Sophia Egger, Mathias Ziegler, Marcel Kwiatkowski, and Ines Heiland
Published in: Analytical and Bioanalytical Chemistry, Issue 413, 2021, Page(s) 7333-7340, ISSN 1618-2650
Publisher: Springer
DOI: 10.1007/s00216-021-03732-7

Systemic tryptophan homeostasis

Author(s): Simon Klaessens, Vincent Stroobant, Etienne De Plaen, Benoit J. Van den Eynde
Published in: Frontiers in Molecular Biosciences, Issue Vol 9 - 2022, 2022, ISSN 2296-889X
Publisher: Frontiers Media
DOI: 10.3389/fmolb.2022.897929

The TSC complex-mTORC1 axis: from lysosomes to stress granules and back

Author(s): Ulrike Rehbein, Mirja Tamara Prentzell, Marti Cadena Sandoval, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz and Kathrin Thedieck
Published in: Frontiers in Cell and Developmental Biology, Issue 9 (2021), 2021, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2021.751892

Comparative Assessment of Quantification Methods for Tumor Tissue Phosphoproteomics

Author(s): Yang Zhang, Benjamin Dreyer, Natalia Govorukhina, Alexander M Heberle, Saša Končarević, Christoph Krisp, Christiane A Opitz, Pauline Pfänder, Rainer Bischoff, Hartmut Schlüter, Marcel Kwiatkowski, Kathrin Thedieck, Peter L Horvatovich
Published in: Analytical Chemistry, Issue Aug 9;94(31), 2022, Page(s) 10893-10906, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.2c01036

Proteome Coverage after Simultaneous Proteo-Metabolome Liquid–Liquid Extraction

Author(s): Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze, Elisabeth Zimmermann, Tobias Kipura, Julia Grander, André Gollowitzer, Andreas Koeberle, Rainer Bischoff, Kathrin Thedieck, and Marcel Kwiatkowski
Published in: Journal of proteome research, Issue 2023, 22, 2023, Page(s) 951 - 966, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.2c00758

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Author(s): Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA
Published in: Theranostics, Issue 11(19), 2021, Page(s) 9217-9233, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.60679

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Author(s): Simon Klaessens, Vincent Stroobant,Delia Hoffmann, Mads Gyrd-Hansen,Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, and Benoit J. Van den Eynde
Published in: PNAS, Issue 118 (23), 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2022447118

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Author(s): Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José Miguel Ramos Pittol, Oliver Kepp, Gerald Hoefler, Albrecht Schmidt, Peter P. Rainer, Daniel Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin The
Published in: Circulation, Issue Vol. 145 No. 25, 2022, Page(s) 1853 - 1866, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059863

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Author(s): Marti Cadena Sandoval, Alexander Martin Heberle, Ulrike Rehbein, Cecilia Barile, José Miguel Ramos Pittol, Kathrin Thedieck
Published in: Frontiers in Aging, Issue Volume 2 - 2021, 2021, ISSN 2673-6217
Publisher: Frontiers Media SA
DOI: 10.3389/fragi.2021.761333

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Author(s): Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A Opitz, Benoit J Van den Eynde, Jingjing Zhu
Published in: Journal for ImmunoTherapy of Cancer, Issue 11 (6), 2023, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2023-006728

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Author(s): Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Published in: Cell, Issue 184/3, 2021, Page(s) 655-674.e27, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.12.024

Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS

Author(s): Alienke van Pijkeren; Jörn Dietze; Alejandro Sánchez Brotons; Anna-Sophia Egger; Tim Lijster; Andrei Barcaru; Madlen Hotze; Philipp Kobler; Frank J. Dekker; Peter Horvatovich; Barbro N. Melgert; Mathias Ziegler; Kathrin Thedieck; Ines Heiland; Rainer Bischoff; Marcel Kwiatkowski
Published in: Analytical Chemistry, Issue Vol. 93, Iss. 38, 2021, Page(s) 12872 - 12880, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c01359

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

Author(s): Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane A Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck
Published in: Life Science Alliance, Issue 2/2, 2019, Page(s) e201800257, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.201800257

Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices

Author(s): Mahdi Shafiee Kamalabad, Alexander Martin Heberle, Kathrin Thedieck, Marco Grzegorczyk
Published in: Bioinformatics, Issue 35/12, 2018, Page(s) 2108-2117, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/bty917

Tomatidine, a novel antiviral compound towards dengue virus

Author(s): Mayra Diosa-Toro, Berit Troost, Denise van de Pol, Alexander Martin Heberle, Silvio Urcuqui-Inchima, Kathrin Thedieck, Jolanda M. Smit
Published in: Antiviral Research, Issue 161, 2019, Page(s) 90-99, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2018.11.011

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Author(s): Michael Platten, Ellen A. A. Nollen, Ute F. Röhrig, Francesca Fallarino, Christiane A. Opitz
Published in: Nature Reviews Drug Discovery, Issue 18/5, 2019, Page(s) 379-401, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-019-0016-5

The SZT2 interactome unravels new functions of the KICSTOR complex

Author(s): Cecilia Cattelani, Dominik Lesiak, Gudrun Liebscher, Isabel I. Singer, Taras Stasyk, Moritz H. Wallnöfer, Alexander M. Heberle, Corrado Corti, Michael W. Hess, Kristian Pfaller, Marcel Kwiatkowski, Peter P. Pramstaller, Andrew A. Hicks, Kathrin Thedieck, Thomas Müller, Lukas A. Huber, and Mariana Eca Guimaraes de Araujo
Published in: Cells, Issue 10 (10) 2021, 2021, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells10102711

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

Author(s): Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina G
Published in: Nature Communications, Issue 13 (2022), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30374-9

Podocytes maintain high basal levels of autophagy independent of mtor signaling.

Author(s): Tillmann Bork; Kosuke Yamahara; Kosuke Yamahara; Shuya Liu; Olivia Lenoir; Ketan Patel; Ketan Patel; Kathrin Thedieck; Kathrin Thedieck; Bjoern Hartleben; Tobias B. Huber; Christoph Schell; Pierre-Louis Tharaux; Wei Liang; Wei Liang; Philipp Lee; Zhejia Tian
Published in: Autophagy, Issue Vol. 16, No.11, 2019, Page(s) 1932-1948, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2019.1705007

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy

Author(s): Zimmer, Philipp; Schmidt, Martina E.; Prentzell, Mirja Tamara; Berdel, Bianca; Wiskemann, Joachim; Kellner, Karl Heinz; Debus, Jürgen; Ulrich, Cornelia; Opitz, Christiane A.; Steindorf, Karen
Published in: Frontiers in Oncology, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00962

Multi-scale modeling of drug binding kinetics to predict drug efficacy

Author(s): Fabirzio Clarelli, Jingyi Liang, Antal Martinecz, Ines Heiland, Pia Abel zur Wiesch
Published in: Cellular and Molecular Life Sciences, Issue 77, 2020, Page(s) 381-394, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-019-03376-y

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Author(s): Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Published in: Cell Stress, Issue Vol. 6, No. 8, 2022, Page(s) 72 - 75, ISSN 2523-0204
Publisher: Shared Science Publishers OG
DOI: 10.15698/cst2022.08.270

Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics

Author(s): Raik Otto; Katharina M. Detjen; Pamela Riemer; Melanie Fattohi; Carsten Grötzinger; Guido Rindi; Bertram Wiedenmann; Christine Sers; Ulf Leser
Published in: Volume 15(3), 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030936

Other (1)

Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain translation and AHR-dependent autophagy

Author(s): Pauline Pfänder; Lucas Hensen; Patricia Razquin Navas; Marie Solvay; Mirja Tamara Prentzell; Ahmed Sadik; Alexander M. Heberle; Sophie Seifert; Leon Regin; Tobias Bausbacher; Anna-Sophia Egger; Madlen Hotze; Tobias Kipura; Bianca Berdel; Ivana Karabogdan; Luis F. Somarribas Patterson; Michele Reil; Deepak Sayeeram; Vera Peters; Jose Ramos Pittol; Ineke van ’t Land-Kuper; Teresa Börding; Saskia
Published in: BioRxiv, 2023
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/2023.01.16.523931

Non-peer reviewed articles (1)

Adaptive Digital Tissue Deconvolution

Author(s): Franziska Görtler; Malte Mensching-Buhr; Ørjan Skaar; Stefan Schrod; Tim Beißbarth; Anagha Joshi; Helena U. Zacharias; Sushma Nagaraja Grellscheid; Michael Altenbuchinger
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.08.527583

Intellectual Property Rights

Patent (3)

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AND RESPECTIVE METABOLITES AS BIOMARKERS FOR CANCER

Application/Publication number: 20 20085647
Date: 2020-12-10
Applicant(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AS A BIOMARKER AND USES THEREOF

Application/Publication number: 20 20060259
Date: 2020-04-09
Applicant(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

AHR SIGNATURE MARKER SET

Application/Publication number: 19 166374
Date: 2019-03-29
Applicant(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG