Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification

Informazioni relative al progetto

MESI-STRAT

ID dell’accordo di sovvenzione: 754688

DOI

10.3030/754688

Progetto chiuso

Data della firma CE 21 Novembre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 30 Settembre 2023

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 949 963,75

Contributo UE

€ 5 949 963,75

Coordinato da

UNIVERSITAET INNSBRUCK
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

MESI-STRAT website with continuous updates

MESI-STRAT website

Documents, reports (1)

WOO trial: Report on status of posting results

WOO trial Report on status of posting results

Pubblicazioni

Peer reviewed articles (33)

The therapeutic potential of targeting tryptophan catabolism in cancer

Autori: Christiane A. Opitz, Luis F. Somarribas Patterson, Soumya R. Mohapatra, Dyah L. Dewi, Ahmed Sadik, Michael Platten, Saskia Trump
Pubblicato in: British Journal of Cancer, Numero 122/1, 2020, Pagina/e 30-44, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-019-0664-6

The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

Autori: Christiane A. Opitz, Pauline Holfelder, Mirja Tamara Prentzell, Saskia Trump
Pubblicato in: Biochemical Pharmacology, Numero 216, October 2023, 2023, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2023.115798

Breaking the Interface: Efficient Extraction of Magnetic Beads from Nanoliter Droplets for Automated Sequential Immunoassays

Autori: Lukas Metzler; Ulrike Rehbein; Jan-Niklas Schönberg; Thomas Brandstetter; Kathrin Thedieck; Jürgen Rühe
Pubblicato in: Analytical Chemistry, Numero 92, 15, 2020, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c00187

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

Autori: Mathias Bockwoldt, Dorothée Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug, Mathias Ziegler, Ines Heiland
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/32, 2019, Pagina/e 15957-15966, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1902346116

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

Autori: Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Michael Platten, Ines Heiland, Christiane A. Opitz
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.590532

T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor 1 antibody penetration and improves PD-L1 blocking at the tumor site

Autori: Pierre-Florent Petit, Raphaële Bombart, Pierre-Hubert Desimple, Stefan Naulaert, Laurie Thouvenel, Jean-François Collet, Benoit Van den Eynde, Jingjing Zhu
Pubblicato in: Cancer Immunology Research, Numero Vol. 10, no. 6, 2022, 2022, Pagina/e 713 - 727, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0801

Finding new edges: systems approaches to MTOR signaling

Autori: Alexander Martin Heberle, Ulrike Rehbein, Maria Rodríguez Peiris, Kathrin Thedieck
Pubblicato in: Biochemical Society Transactions, Numero 49/1, 2021, Pagina/e 41-54, ISSN 0300-5127
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20190730

Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25

Autori: Mathias Ziegler, Magnus Monné, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, and Ferdinando Palmieri
Pubblicato in: Biomolecules, Numero 11(6), 880, 2021, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom11060880

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Autori: Ahmed Sadik, Luis F. Somarribas Patterson, Selcen Öztürk, Soumya R. Mohapatra, Verena Panitz, Philipp F. Secker, Pauline Pfänder, Stefanie Loth, Heba Salem, Mirja Tamara Prentzell, Bianca Berdel, Murat Iskar, Erik Faessler, Friederike Reuter, Isabelle Kirst, Verena Kalter, Kathrin I. Foerster, Evelyn Jäger, Carina Ramallo Guevara, Mansour Sobeh, Thomas Hielscher, Gernot Poschet, Annekathrin Re
Pubblicato in: Cell, Numero 182/5, 2020, Pagina/e 1252-1270.e34, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.07.038

Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.

Autori: Benoît Van den Eynde
Pubblicato in: Cancer immunology research, Vol. 9, no.8, p. 854 (2021), 2021, Pagina/e 854, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0432

Natural isotope correction improves analysis of protein modification dynamics

Autori: Jörn Dietze,Alienke van Pijkeren, Anna-Sophia Egger, Mathias Ziegler, Marcel Kwiatkowski, and Ines Heiland
Pubblicato in: Analytical and Bioanalytical Chemistry, Numero 413, 2021, Pagina/e 7333-7340, ISSN 1618-2650
Editore: Springer
DOI: 10.1007/s00216-021-03732-7

Systemic tryptophan homeostasis

Autori: Simon Klaessens, Vincent Stroobant, Etienne De Plaen, Benoit J. Van den Eynde
Pubblicato in: Frontiers in Molecular Biosciences, Numero Vol 9 - 2022, 2022, ISSN 2296-889X
Editore: Frontiers Media
DOI: 10.3389/fmolb.2022.897929

The TSC complex-mTORC1 axis: from lysosomes to stress granules and back

Autori: Ulrike Rehbein, Mirja Tamara Prentzell, Marti Cadena Sandoval, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz and Kathrin Thedieck
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9 (2021), 2021, ISSN 2296-634X
Editore: Frontiers Media
DOI: 10.3389/fcell.2021.751892

Comparative Assessment of Quantification Methods for Tumor Tissue Phosphoproteomics

Autori: Yang Zhang, Benjamin Dreyer, Natalia Govorukhina, Alexander M Heberle, Saša Končarević, Christoph Krisp, Christiane A Opitz, Pauline Pfänder, Rainer Bischoff, Hartmut Schlüter, Marcel Kwiatkowski, Kathrin Thedieck, Peter L Horvatovich
Pubblicato in: Analytical Chemistry, Numero Aug 9;94(31), 2022, Pagina/e 10893-10906, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.2c01036

Proteome Coverage after Simultaneous Proteo-Metabolome Liquid–Liquid Extraction

Autori: Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze, Elisabeth Zimmermann, Tobias Kipura, Julia Grander, André Gollowitzer, Andreas Koeberle, Rainer Bischoff, Kathrin Thedieck, and Marcel Kwiatkowski
Pubblicato in: Journal of proteome research, Numero 2023, 22, 2023, Pagina/e 951 - 966, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.2c00758

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Autori: Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA
Pubblicato in: Theranostics, Numero 11(19), 2021, Pagina/e 9217-9233, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.60679

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Autori: Simon Klaessens, Vincent Stroobant,Delia Hoffmann, Mads Gyrd-Hansen,Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, and Benoit J. Van den Eynde
Pubblicato in: PNAS, Numero 118 (23), 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2022447118

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Autori: Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José Miguel Ramos Pittol, Oliver Kepp, Gerald Hoefler, Albrecht Schmidt, Peter P. Rainer, Daniel Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin The
Pubblicato in: Circulation, Numero Vol. 145 No. 25, 2022, Pagina/e 1853 - 1866, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059863

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Autori: Marti Cadena Sandoval, Alexander Martin Heberle, Ulrike Rehbein, Cecilia Barile, José Miguel Ramos Pittol, Kathrin Thedieck
Pubblicato in: Frontiers in Aging, Numero Volume 2 - 2021, 2021, ISSN 2673-6217
Editore: Frontiers Media SA
DOI: 10.3389/fragi.2021.761333

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Autori: Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A Opitz, Benoit J Van den Eynde, Jingjing Zhu
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 11 (6), 2023, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2023-006728

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Autori: Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Pubblicato in: Cell, Numero 184/3, 2021, Pagina/e 655-674.e27, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.12.024

Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS

Autori: Alienke van Pijkeren; Jörn Dietze; Alejandro Sánchez Brotons; Anna-Sophia Egger; Tim Lijster; Andrei Barcaru; Madlen Hotze; Philipp Kobler; Frank J. Dekker; Peter Horvatovich; Barbro N. Melgert; Mathias Ziegler; Kathrin Thedieck; Ines Heiland; Rainer Bischoff; Marcel Kwiatkowski
Pubblicato in: Analytical Chemistry, Numero Vol. 93, Iss. 38, 2021, Pagina/e 12872 - 12880, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.1c01359

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

Autori: Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane A Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck
Pubblicato in: Life Science Alliance, Numero 2/2, 2019, Pagina/e e201800257, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.201800257

Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices

Autori: Mahdi Shafiee Kamalabad, Alexander Martin Heberle, Kathrin Thedieck, Marco Grzegorczyk
Pubblicato in: Bioinformatics, Numero 35/12, 2018, Pagina/e 2108-2117, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/bty917

Tomatidine, a novel antiviral compound towards dengue virus

Autori: Mayra Diosa-Toro, Berit Troost, Denise van de Pol, Alexander Martin Heberle, Silvio Urcuqui-Inchima, Kathrin Thedieck, Jolanda M. Smit
Pubblicato in: Antiviral Research, Numero 161, 2019, Pagina/e 90-99, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2018.11.011

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Autori: Michael Platten, Ellen A. A. Nollen, Ute F. Röhrig, Francesca Fallarino, Christiane A. Opitz
Pubblicato in: Nature Reviews Drug Discovery, Numero 18/5, 2019, Pagina/e 379-401, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-019-0016-5

The SZT2 interactome unravels new functions of the KICSTOR complex

Autori: Cecilia Cattelani, Dominik Lesiak, Gudrun Liebscher, Isabel I. Singer, Taras Stasyk, Moritz H. Wallnöfer, Alexander M. Heberle, Corrado Corti, Michael W. Hess, Kristian Pfaller, Marcel Kwiatkowski, Peter P. Pramstaller, Andrew A. Hicks, Kathrin Thedieck, Thomas Müller, Lukas A. Huber, and Mariana Eca Guimaraes de Araujo
Pubblicato in: Cells, Numero 10 (10) 2021, 2021, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells10102711

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

Autori: Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina G
Pubblicato in: Nature Communications, Numero 13 (2022), 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30374-9

Podocytes maintain high basal levels of autophagy independent of mtor signaling.

Autori: Tillmann Bork; Kosuke Yamahara; Kosuke Yamahara; Shuya Liu; Olivia Lenoir; Ketan Patel; Ketan Patel; Kathrin Thedieck; Kathrin Thedieck; Bjoern Hartleben; Tobias B. Huber; Christoph Schell; Pierre-Louis Tharaux; Wei Liang; Wei Liang; Philipp Lee; Zhejia Tian
Pubblicato in: Autophagy, Numero Vol. 16, No.11, 2019, Pagina/e 1932-1948, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2019.1705007

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy

Autori: Zimmer, Philipp; Schmidt, Martina E.; Prentzell, Mirja Tamara; Berdel, Bianca; Wiskemann, Joachim; Kellner, Karl Heinz; Debus, Jürgen; Ulrich, Cornelia; Opitz, Christiane A.; Steindorf, Karen
Pubblicato in: Frontiers in Oncology, 2019, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00962

Multi-scale modeling of drug binding kinetics to predict drug efficacy

Autori: Fabirzio Clarelli, Jingyi Liang, Antal Martinecz, Ines Heiland, Pia Abel zur Wiesch
Pubblicato in: Cellular and Molecular Life Sciences, Numero 77, 2020, Pagina/e 381-394, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-019-03376-y

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Autori: Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Pubblicato in: Cell Stress, Numero Vol. 6, No. 8, 2022, Pagina/e 72 - 75, ISSN 2523-0204
Editore: Shared Science Publishers OG
DOI: 10.15698/cst2022.08.270

Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics

Autori: Raik Otto; Katharina M. Detjen; Pamela Riemer; Melanie Fattohi; Carsten Grötzinger; Guido Rindi; Bertram Wiedenmann; Christine Sers; Ulf Leser
Pubblicato in: Volume 15(3), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030936

Other (1)

Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain translation and AHR-dependent autophagy

Autori: Pauline Pfänder; Lucas Hensen; Patricia Razquin Navas; Marie Solvay; Mirja Tamara Prentzell; Ahmed Sadik; Alexander M. Heberle; Sophie Seifert; Leon Regin; Tobias Bausbacher; Anna-Sophia Egger; Madlen Hotze; Tobias Kipura; Bianca Berdel; Ivana Karabogdan; Luis F. Somarribas Patterson; Michele Reil; Deepak Sayeeram; Vera Peters; Jose Ramos Pittol; Ineke van ’t Land-Kuper; Teresa Börding; Saskia
Pubblicato in: BioRxiv, 2023
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/2023.01.16.523931

Non-peer reviewed articles (1)

Adaptive Digital Tissue Deconvolution

Autori: Franziska Görtler; Malte Mensching-Buhr; Ørjan Skaar; Stefan Schrod; Tim Beißbarth; Anagha Joshi; Helena U. Zacharias; Sushma Nagaraja Grellscheid; Michael Altenbuchinger
Pubblicato in: bioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.08.527583

Diritti di proprietà intellettuale

Patent (3)

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AND RESPECTIVE METABOLITES AS BIOMARKERS FOR CANCER

Numero candidatura/pubblicazione: 20 20085647
Data: 2020-12-10
Candidato/i: DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AS A BIOMARKER AND USES THEREOF

Numero candidatura/pubblicazione: 20 20060259
Data: 2020-04-09
Candidato/i: DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

AHR SIGNATURE MARKER SET

Numero candidatura/pubblicazione: 19 166374
Data: 2019-03-29
Candidato/i: DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG