Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification

Información del proyecto

MESI-STRAT

Identificador del acuerdo de subvención: 754688

DOI

10.3030/754688

Proyecto cerrado

Fecha de la firma de la CE 21 Noviembre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Septiembre 2023

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 949 963,75

Aportación de la UE

€ 5 949 963,75

Coordinado por

UNIVERSITAET INNSBRUCK
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

MESI-STRAT website with continuous updates

MESI-STRAT website

Documents, reports (1)

WOO trial: Report on status of posting results

WOO trial Report on status of posting results

Publicaciones

Peer reviewed articles (33)

The therapeutic potential of targeting tryptophan catabolism in cancer

Autores: Christiane A. Opitz, Luis F. Somarribas Patterson, Soumya R. Mohapatra, Dyah L. Dewi, Ahmed Sadik, Michael Platten, Saskia Trump
Publicado en: British Journal of Cancer, Edición 122/1, 2020, Página(s) 30-44, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-019-0664-6

The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

Autores: Christiane A. Opitz, Pauline Holfelder, Mirja Tamara Prentzell, Saskia Trump
Publicado en: Biochemical Pharmacology, Edición 216, October 2023, 2023, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2023.115798

Breaking the Interface: Efficient Extraction of Magnetic Beads from Nanoliter Droplets for Automated Sequential Immunoassays

Autores: Lukas Metzler; Ulrike Rehbein; Jan-Niklas Schönberg; Thomas Brandstetter; Kathrin Thedieck; Jürgen Rühe
Publicado en: Analytical Chemistry, Edición 92, 15, 2020, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.0c00187

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

Autores: Mathias Bockwoldt, Dorothée Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug, Mathias Ziegler, Ines Heiland
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/32, 2019, Página(s) 15957-15966, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1902346116

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

Autores: Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Michael Platten, Ines Heiland, Christiane A. Opitz
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.590532

T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor 1 antibody penetration and improves PD-L1 blocking at the tumor site

Autores: Pierre-Florent Petit, Raphaële Bombart, Pierre-Hubert Desimple, Stefan Naulaert, Laurie Thouvenel, Jean-François Collet, Benoit Van den Eynde, Jingjing Zhu
Publicado en: Cancer Immunology Research, Edición Vol. 10, no. 6, 2022, 2022, Página(s) 713 - 727, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0801

Finding new edges: systems approaches to MTOR signaling

Autores: Alexander Martin Heberle, Ulrike Rehbein, Maria Rodríguez Peiris, Kathrin Thedieck
Publicado en: Biochemical Society Transactions, Edición 49/1, 2021, Página(s) 41-54, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20190730

Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25

Autores: Mathias Ziegler, Magnus Monné, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, and Ferdinando Palmieri
Publicado en: Biomolecules, Edición 11(6), 880, 2021, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom11060880

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Autores: Ahmed Sadik, Luis F. Somarribas Patterson, Selcen Öztürk, Soumya R. Mohapatra, Verena Panitz, Philipp F. Secker, Pauline Pfänder, Stefanie Loth, Heba Salem, Mirja Tamara Prentzell, Bianca Berdel, Murat Iskar, Erik Faessler, Friederike Reuter, Isabelle Kirst, Verena Kalter, Kathrin I. Foerster, Evelyn Jäger, Carina Ramallo Guevara, Mansour Sobeh, Thomas Hielscher, Gernot Poschet, Annekathrin Re
Publicado en: Cell, Edición 182/5, 2020, Página(s) 1252-1270.e34, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.07.038

Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.

Autores: Benoît Van den Eynde
Publicado en: Cancer immunology research, Vol. 9, no.8, p. 854 (2021), 2021, Página(s) 854, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0432

Natural isotope correction improves analysis of protein modification dynamics

Autores: Jörn Dietze,Alienke van Pijkeren, Anna-Sophia Egger, Mathias Ziegler, Marcel Kwiatkowski, and Ines Heiland
Publicado en: Analytical and Bioanalytical Chemistry, Edición 413, 2021, Página(s) 7333-7340, ISSN 1618-2650
Editor: Springer
DOI: 10.1007/s00216-021-03732-7

Systemic tryptophan homeostasis

Autores: Simon Klaessens, Vincent Stroobant, Etienne De Plaen, Benoit J. Van den Eynde
Publicado en: Frontiers in Molecular Biosciences, Edición Vol 9 - 2022, 2022, ISSN 2296-889X
Editor: Frontiers Media
DOI: 10.3389/fmolb.2022.897929

The TSC complex-mTORC1 axis: from lysosomes to stress granules and back

Autores: Ulrike Rehbein, Mirja Tamara Prentzell, Marti Cadena Sandoval, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz and Kathrin Thedieck
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9 (2021), 2021, ISSN 2296-634X
Editor: Frontiers Media
DOI: 10.3389/fcell.2021.751892

Comparative Assessment of Quantification Methods for Tumor Tissue Phosphoproteomics

Autores: Yang Zhang, Benjamin Dreyer, Natalia Govorukhina, Alexander M Heberle, Saša Končarević, Christoph Krisp, Christiane A Opitz, Pauline Pfänder, Rainer Bischoff, Hartmut Schlüter, Marcel Kwiatkowski, Kathrin Thedieck, Peter L Horvatovich
Publicado en: Analytical Chemistry, Edición Aug 9;94(31), 2022, Página(s) 10893-10906, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.2c01036

Proteome Coverage after Simultaneous Proteo-Metabolome Liquid–Liquid Extraction

Autores: Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze, Elisabeth Zimmermann, Tobias Kipura, Julia Grander, André Gollowitzer, Andreas Koeberle, Rainer Bischoff, Kathrin Thedieck, and Marcel Kwiatkowski
Publicado en: Journal of proteome research, Edición 2023, 22, 2023, Página(s) 951 - 966, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.2c00758

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Autores: Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA
Publicado en: Theranostics, Edición 11(19), 2021, Página(s) 9217-9233, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.60679

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Autores: Simon Klaessens, Vincent Stroobant,Delia Hoffmann, Mads Gyrd-Hansen,Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, and Benoit J. Van den Eynde
Publicado en: PNAS, Edición 118 (23), 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2022447118

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Autores: Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José Miguel Ramos Pittol, Oliver Kepp, Gerald Hoefler, Albrecht Schmidt, Peter P. Rainer, Daniel Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin The
Publicado en: Circulation, Edición Vol. 145 No. 25, 2022, Página(s) 1853 - 1866, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059863

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Autores: Marti Cadena Sandoval, Alexander Martin Heberle, Ulrike Rehbein, Cecilia Barile, José Miguel Ramos Pittol, Kathrin Thedieck
Publicado en: Frontiers in Aging, Edición Volume 2 - 2021, 2021, ISSN 2673-6217
Editor: Frontiers Media SA
DOI: 10.3389/fragi.2021.761333

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Autores: Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A Opitz, Benoit J Van den Eynde, Jingjing Zhu
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 11 (6), 2023, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2023-006728

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Autores: Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Publicado en: Cell, Edición 184/3, 2021, Página(s) 655-674.e27, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.12.024

Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS

Autores: Alienke van Pijkeren; Jörn Dietze; Alejandro Sánchez Brotons; Anna-Sophia Egger; Tim Lijster; Andrei Barcaru; Madlen Hotze; Philipp Kobler; Frank J. Dekker; Peter Horvatovich; Barbro N. Melgert; Mathias Ziegler; Kathrin Thedieck; Ines Heiland; Rainer Bischoff; Marcel Kwiatkowski
Publicado en: Analytical Chemistry, Edición Vol. 93, Iss. 38, 2021, Página(s) 12872 - 12880, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c01359

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

Autores: Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane A Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck
Publicado en: Life Science Alliance, Edición 2/2, 2019, Página(s) e201800257, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.201800257

Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices

Autores: Mahdi Shafiee Kamalabad, Alexander Martin Heberle, Kathrin Thedieck, Marco Grzegorczyk
Publicado en: Bioinformatics, Edición 35/12, 2018, Página(s) 2108-2117, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/bty917

Tomatidine, a novel antiviral compound towards dengue virus

Autores: Mayra Diosa-Toro, Berit Troost, Denise van de Pol, Alexander Martin Heberle, Silvio Urcuqui-Inchima, Kathrin Thedieck, Jolanda M. Smit
Publicado en: Antiviral Research, Edición 161, 2019, Página(s) 90-99, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2018.11.011

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Autores: Michael Platten, Ellen A. A. Nollen, Ute F. Röhrig, Francesca Fallarino, Christiane A. Opitz
Publicado en: Nature Reviews Drug Discovery, Edición 18/5, 2019, Página(s) 379-401, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/s41573-019-0016-5

The SZT2 interactome unravels new functions of the KICSTOR complex

Autores: Cecilia Cattelani, Dominik Lesiak, Gudrun Liebscher, Isabel I. Singer, Taras Stasyk, Moritz H. Wallnöfer, Alexander M. Heberle, Corrado Corti, Michael W. Hess, Kristian Pfaller, Marcel Kwiatkowski, Peter P. Pramstaller, Andrew A. Hicks, Kathrin Thedieck, Thomas Müller, Lukas A. Huber, and Mariana Eca Guimaraes de Araujo
Publicado en: Cells, Edición 10 (10) 2021, 2021, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells10102711

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

Autores: Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina G
Publicado en: Nature Communications, Edición 13 (2022), 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30374-9

Podocytes maintain high basal levels of autophagy independent of mtor signaling.

Autores: Tillmann Bork; Kosuke Yamahara; Kosuke Yamahara; Shuya Liu; Olivia Lenoir; Ketan Patel; Ketan Patel; Kathrin Thedieck; Kathrin Thedieck; Bjoern Hartleben; Tobias B. Huber; Christoph Schell; Pierre-Louis Tharaux; Wei Liang; Wei Liang; Philipp Lee; Zhejia Tian
Publicado en: Autophagy, Edición Vol. 16, No.11, 2019, Página(s) 1932-1948, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2019.1705007

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy

Autores: Zimmer, Philipp; Schmidt, Martina E.; Prentzell, Mirja Tamara; Berdel, Bianca; Wiskemann, Joachim; Kellner, Karl Heinz; Debus, Jürgen; Ulrich, Cornelia; Opitz, Christiane A.; Steindorf, Karen
Publicado en: Frontiers in Oncology, 2019, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00962

Multi-scale modeling of drug binding kinetics to predict drug efficacy

Autores: Fabirzio Clarelli, Jingyi Liang, Antal Martinecz, Ines Heiland, Pia Abel zur Wiesch
Publicado en: Cellular and Molecular Life Sciences, Edición 77, 2020, Página(s) 381-394, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-019-03376-y

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Autores: Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Publicado en: Cell Stress, Edición Vol. 6, No. 8, 2022, Página(s) 72 - 75, ISSN 2523-0204
Editor: Shared Science Publishers OG
DOI: 10.15698/cst2022.08.270

Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics

Autores: Raik Otto; Katharina M. Detjen; Pamela Riemer; Melanie Fattohi; Carsten Grötzinger; Guido Rindi; Bertram Wiedenmann; Christine Sers; Ulf Leser
Publicado en: Volume 15(3), 2023, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030936

Other (1)

Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain translation and AHR-dependent autophagy

Autores: Pauline Pfänder; Lucas Hensen; Patricia Razquin Navas; Marie Solvay; Mirja Tamara Prentzell; Ahmed Sadik; Alexander M. Heberle; Sophie Seifert; Leon Regin; Tobias Bausbacher; Anna-Sophia Egger; Madlen Hotze; Tobias Kipura; Bianca Berdel; Ivana Karabogdan; Luis F. Somarribas Patterson; Michele Reil; Deepak Sayeeram; Vera Peters; Jose Ramos Pittol; Ineke van ’t Land-Kuper; Teresa Börding; Saskia
Publicado en: BioRxiv, 2023
Editor: Cold Spring Harbour Laboratory
DOI: 10.1101/2023.01.16.523931

Non-peer reviewed articles (1)

Adaptive Digital Tissue Deconvolution

Autores: Franziska Görtler; Malte Mensching-Buhr; Ørjan Skaar; Stefan Schrod; Tim Beißbarth; Anagha Joshi; Helena U. Zacharias; Sushma Nagaraja Grellscheid; Michael Altenbuchinger
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.08.527583

Derechos de propiedad intelectual

Patent (3)

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AND RESPECTIVE METABOLITES AS BIOMARKERS FOR CANCER

Número de solicitud/publicación: 20 20085647
Fecha: 2020-12-10
Solicitante(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

INTERLEUKIN-4-INDUCED GENE 1 (IL4I1) AS A BIOMARKER AND USES THEREOF

Número de solicitud/publicación: 20 20060259
Fecha: 2020-04-09
Solicitante(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

AHR SIGNATURE MARKER SET

Número de solicitud/publicación: 19 166374
Fecha: 2019-03-29
Solicitante(s): DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG