The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Información del proyecto

EU-TRAIN

Identificador del acuerdo de subvención: 754995

DOI

10.3030/754995

Proyecto cerrado

Fecha de la firma de la CE 27 Noviembre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 641 546,00

Aportación de la UE

€ 6 641 546,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

EUTRAIN-ESOT statistics course on risk stratification
EU-TRAIN session in ESOT events

EU-TRAIN session in ESOT events (M28 and M54)

Websites, patent fillings, videos etc. (1)

Communication and Dissemination tools

Publicaciones

Peer reviewed articles (30)

Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization

Autores: Júlia Nakanishi Usuda, Desirée Rodrigues Plaça, Dennyson Leandro M. Fonseca, Alexandre H. C. Marques, Igor Salerno Filgueiras, Victor Gabriel Bastos Chaves, Anny Silva Adri, Amanda Torrentes-Carvalho, Mario Hiroyuki Hirata, Paula Paccielli Freire, Rusan Catar, Gustavo Cabral-Miranda, Lena F. Schimke, Guido Moll, Otavio Cabral-Marques
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Fron. Immunol.
DOI: 10.3389/fimmu.2023.1243516

Surfing the Big Data Wave: Omics Data Challenges in Transplantation

Autores: Ba, Rokhaya; Geffard, Estelle; Douillard, Venceslas; Simon, Françoise; Mesnard, Laurent; Vince, Nicolas ; Gourraud, Pierre-Antoine; Limou, Sophie
Publicado en: Transplantation, 2021, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000003992

Multiple sclerosis clinical decision support system based on projection to reference datasets

Autores: Chadia Ed-driouch , Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David-Axel Laplaud, Franck Mars, Cedric Dumas, Gilles Edan & Pierre-Antoine Gourraud
Publicado en: Annals of Clinical and Translational Neurology, Edición Volume 9, Edición 12, 2022, Página(s) 1863-1873, ISSN 2328-9503
Editor: -
DOI: 10.1002/acn3.51649

Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression

Autores: Danger R, Le Berre L, Cadoux M, Kerleau C, Papuchon E, Mai HL, Nguyen TV, Guérif P, Morelon E, Thaunat O, Legendre C, Anglicheau D, Lefaucheur C, Couzi L, Del Bello A, Kamar N, Le Quintrec M, Goutaudier V, Renaudin K, Giral M, Brouard S; DIVAT Consortium
Publicado en: Kidney International, Edición 2023 Jun;103(6):1167-1179, 2023, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.03.019

CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy

Autores: Marta Jarque, Edoardo Melilli, Elena Crespo, Anna Manonelles, Nuria Montero, Joan Torras, Josep M. Cruzado, Sergi Luque, Salvador Gil-Vernet, Josep M. Grinyó, Oriol Bestard
Publicado en: Transplantation, Edición 102, 2023, Página(s) e472-e480, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000002421

Addressing the Challenges and Barriers to the Integration of Machine Learning into Clinical Practice: An Innovative Method to Hybrid Human–Machine Intelligence

Autores: Chadia Ed-driouch, Franck Mars, Pierre-Antoine Gourraud, Cédric Dumas
Publicado en: Sensors, Edición Volume 22, Edición 21, 2022, Página(s) 8313, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22218313

A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

Autores: Daniel Yoo, Gillian Divard, Marc Raynaud, Aaron Cohen, Tom D. Mone, John Thomas Rosenthal, Andrew J. Bentall, Mark D. Stegall, Maarten Naesens, Huanxi Zhang, Changxi Wang, Juliette Gueguen, Nassim Kamar, Antoine Bouquegneau, Ibrahim Batal, Shana M. Coley, John S. Gill, Federico Oppenheimer, Erika De Sousa-Amorim, Dirk R. J. Kuypers, Antoine Durrbach, Daniel Seron, Marion Rabant, Jean-Paul Duong Va
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-44595-z

Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)

Autores: François R Girardin, Anna Nicolet, Oriol Bestard, Carmen Lefaucheur, Klemens Budde, Fabian Halleck, Sophie Brouard, Magali Giral, Pierre-Antoine Gourraud, Béatrice Horcholle, Jean Villard, Joachim Marti, Alexandre Loupy
Publicado en: Frontiers in Pharmacology, Edición 2023 April 27, 2023, Página(s) 14:1040584, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1040584

High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients

Autores: Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, José Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta, Irina B. Torres, Joana Sellarés, Manel Perelló, Hannah Kaminski, Lionel Couzi, Alexandre Loupy, Gaetano La Manna, Francesc Moreso, Paolo Crave
Publicado en: Kidney International, 2024, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.03.027

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling

Autores: Guido Moll, Christian Luecht, Michael Adu Gyamfi, Dennyson L. M. da Fonseca, Pinchao Wang, Hongfan Zhao, Zexian Gong, Lei Chen, Muhamad Imtiaz Ashraf, Harald Heidecke, Alexander Maximilian Hackel, Duska Dragun, Klemens Budde, Olaf Penack, Gabriela Riemekasten, Otávio Cabral-Marques, Janusz Witowski, Rusan Catar
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1289744

Distributing HLA database in histocompatibility: a shift in HLA data governance

Autores: Sirine Sayadi 1, 2 Venceslas Douillard 3, 4 Nicolas Vince 3, 4 Mario Südholt 1, 2 Pierre-Antoine Gourraud 4, 3 
Publicado en: Exploration of Immunology , 2022, ISSN 2768-6655
Editor: Exploration of Immunology 

Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study

Autores: Raynaud M, Al-Awadhi S, Juric I, Divard G, Lombardi Y, Basic-Jukic N, Aubert O, Dubourg L, Masson I, Mariat C, Prié D, Pernin V, Le Quintrec M, Larson TS, Stegall MD, Bikbov B, Ruggenenti P, Mesnard L, Ibrahim HN, Nielsen MB, Matas AJ, Nankivell BJ, Benjamens S, Pol RA, Bakker SJL, Jouven X, Legendre C, Kamar N, Smith BH, Wadei HM, Durrbach A, Vincenti F, Remuzzi G, Lefaucheur C, Bentall AJ, Loup
Publicado en: The BMJ, Edición 2023 May, 2023, Página(s) 381:e073654, ISSN 0959-8138
Editor: BMJ
DOI: 10.1136/bmj-2022-073654

An automated histological classification system for precision diagnostics of kidney allografts

Autores: Yoo D, Goutaudier V, Divard G, Gueguen J, Astor BC, Aubert O, Raynaud M, Demir Z, Hogan J, Weng P, Smith J, Garro R, Warady BA, Zahr RS, Sablik M, Twombley K, Couzi L, Berney T, Boyer O, Duong-Van-Huyen JP, Giral M, Alsadi A, Gourraud PA, Morelon E, Le Quintrec M, Brouard S, Legendre C, Anglicheau D, Villard J, Zhong W, Kamar N, Bestard O, Djamali A, Budde K, Haas M, Lefaucheur C, Rabant M, Loupy
Publicado en: Nature medicine, Edición 2023 May, 2023, Página(s) 29(5):1211-1220, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-023-02323-6

Comparison of artificial intelligence and human-based prediction and stratification of the risk of long-term kidney allograft failure.

Autores: Divard G, Raynaud M, Tatapudi VS, Abdalla B, Bailly E, Assayag M, Binois Y, Cohen R, Zhang H, Ulloa C, Linhares K, Tedesco HS, Legendre C, Jouven X, Montgomery RA, Lefaucheur C, Aubert O, Loupy A
Publicado en: Communications medicine, Edición 2022 Nov, 2022, Página(s) 2(1):150, ISSN 2730-664X
Editor: PubMed Central
DOI: 10.1038/s43856-022-00201-9

Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

Autores: Valentin Goutaudier, Richard Danger, Rusan Ali Catar, Maud Racapé, Aurélie Philippe, Michelle Elias, Marc Raynaud, Olivier Aubert, Didier Bouton, François Girardin, Éric Vicaut, Sarhan Yaiche, Jacques Demotes, Harald Heidecke, Jean-Luc Taupin, Christine Randoux-Lebrun, Mohamad Zaidan, Emmanuelle Papuchon, Hoa Le Mai, Thi-Van-Ha Nguyen, Francesc Moreso, Thierry Berney, Jean Villard, Christophe
Publicado en: Kidney International, 2024, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.07.027

Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients

Autores: Gillian Divard, Olivier Aubert, Charlotte Debiais-Deschamp, Marc Raynaud, Valentin Goutaudier, Marta Sablik, Caroline Sayeg, Christophe Legendre, Julie Obert, Dany Anglicheau, Carmen Lefaucheur, Alexandre Loupy
Publicado en: Clinical Journal of the American Society of Nephrology, 2024, ISSN 1555-9041
Editor: American Society of Nephrology
DOI: 10.2215/cjn.0000000000000411

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

Autores: Thayna Silva-Sousa, Júlia Nakanishi Usuda, Nada Al-Arawe, Francisca Frias, Irene Hinterseher, Rusan Catar, Christian Luecht, Katarina Riesner, Alexander Hackel, Lena F Schimke, Haroldo Dutra Dias, Igor Salerno Filgueiras, Helder I Nakaya, Niels Olsen Saraiva Camara, Stefan Fischer, Gabriela Riemekasten, Olle Ringdén, Olaf Penack, Tobias Winkler, Georg Duda, Dennyson Leandro M Fonseca, Otávio Ca
Publicado en: Stem Cells, 2024, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxae054

The Pseudokinase TRIB1 in Immune Cells and Associated Disorders

Autores: Richard Danger, Yodit Feseha and Sophie Brouard
Publicado en: Cancers, 2022, Página(s) 14(4), ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14041011

Pretransplant Donor-specific IFNγ ELISPOT as a Predictor of Graft Rejection

Autores: Nuria Montero, Samira Farouk, Ilaria Gandolfini, Elena Crespo, Marta Jarque, Maria Meneghini, Alba Torija, Umberto Maggiore, Paolo Cravedi, Oriol Bestard
Publicado en: Transplantation Direct, Edición 5/5, 2019, Página(s) e451, ISSN 2373-8731
Editor: Wolters Kluwer Health, Inc
DOI: 10.1097/txd.0000000000000886

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation

Autores: François Brinas, Richard Danger and Sophie Brouard
Publicado en: Cells, 2021, Página(s) 10(6), ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10061367

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

Autores: Esteban Cortes Garcia, Alessia Giarraputo, Maud Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, Marc Raynaud, Clément Couderau, Fariza Mezine, Jessie Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, Fabian Halleck, Magali Giral, Sophie Brouard, Richard Danger, Pierre-Antoine Gourraud, Marion Rabant, Lionel Couzi, Moglie Le Quintrec, Nassim Kamar, Emmanu
Publicado en: Transplant International, Edición 37, 2024, ISSN 1432-2277
Editor: Wiley
DOI: 10.3389/ti.2024.13043

Editorial: Emerging talents in alloimmunity and transplantation: 2022

Autores: Guido Moll, Wai H. Lim, Olaf Penack
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Front. Immunol.
DOI: 10.3389/fimmu.2024.1393026

An exome-wide study of renal operational tolerance

Autores: Massart A*, Danger R*, Olsen C*, Emond M J, Viklicky O, Jacquemin V, Soblet J, Croes D, Perazzolo C, Hruba P, Daneels D, Caljon B, Sever M S, Pascual J, Pirson I, Ghisdal L, Smits G, Giral M, Abramowicz D, Abramowicz M and Brouard S
Publicado en: Frontiers in Medicine, Edición 17 May 2023 Sec. Nephrology Volume 9 - 2022, 2023, ISSN 2296-858X
Editor: -
DOI: 10.3389/fmed.2022.976248

FaDA: A web application for regular laboratory data analyses

Autores: Danger R, Moiteaux Q, Feseha Y, Geffard E, Ramstein G, Brouard S
Publicado en: PLoS One, 2021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0261083

Secure distribution of Factor Analysis of Mixed Data (FAMD) and its application to personalized medicine of transplanted patients

Autores: S Sayadi, E Geffard, M Südholt, N Vince, PA Gourraud
Publicado en: Springer nature, 2021, ISSN 2509-4807
Editor: Springer
DOI: 10.1007/978-3-030-75100-5_44

Structural insights into the catalytic mechanism of granzyme B upon substrate and inhibitor binding

Autores: Tripathi N, Danger R, Chesneau M, Brouard S, Laurent AD
Publicado en: Journal of Molecular Graphics and Modelling, Edición 2022 Mar 22;114:108167, 2022, ISSN 1873-4243
Editor: ELSEVIER
DOI: 10.1016/j.jmgm.2022.108167

Prognostic Biomarkers in Kidney Transplantation: A Systematic Review and Critical Appraisal

Autores: Marc Raynaud, Solaf Al-Awadhi, Kevin Louis, Huanxi Zhang, Xiaojun Su, Valentin Goutaudier, Jiali Wang, Zeynep Demir, Yongcheng Wei, Agathe Truchot, Antoine Bouquegneau, Arnaud Del Bello, Élodie Bailly, Yannis Lombardi, Mehdi Maanaoui, Alessia Giarraputo, Sofia Naser, Gillian Divard, Olivier Aubert, Mohammad Hassan Murad, Changxi Wang, Longshan Liu, Oriol Bestard, Maarten Naesens, John J. Friedewa
Publicado en: Journal of the American Society of Nephrology, Edición 35, 2024, Página(s) 177-188, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.0000000000000260

Blood Gene Signature as a Biomarker for Subclinical Kidney Allograft Rejection: Where Are We?

Autores: Christophe Masset, Richard Danger, Nicolas Degauque, Jacques Dantal, Magali Giral, Sophie Brouard
Publicado en: Transplantation, 2024, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000005105

Editorial: Pharmacoeconomics in the era of health technology assessment and outcomes research to prioritize resource use, innovation and investmentwww.frontiersin.org

Autores: François R. Girardin1, Karen Cohen, Matthias Schwenkglenks, Isabelle Durand-Zaleski
Publicado en: Frontiers in Pharmacology, Edición 2023 May 16, 2023, Página(s) 14:1210002, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1210002

Relevance of the Banff Human Organ Transplant Consensus Gene Panel for Detecting Antibody and T-Cell–Mediated Rejection of Kidney Allografts

Autores: Alessia Giarraputo, Valentin Goutaudier, Blaise Robin, Annalisa Angelini, Marta Sablik, Olivier Aubert, Ivy A. Rosales, Rex N. Smith, Candice Roufosse, Benjamin Adam, Mark Haas, Robert B. Colvin, Carmen Lefaucheur, Michael Mengel, Dina Zielinski, Alexandre Loupy
Publicado en: Kidney International Reports, Edición 9, 2024, Página(s) 2290-2294, ISSN 2468-0249
Editor: Elsevier Inc.
DOI: 10.1016/j.ekir.2024.04.054