The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Risultati finali

EU-TRAIN session in ESOT events (M28 and M54)

Pubblicazioni

Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization

Autori: Júlia Nakanishi Usuda, Desirée Rodrigues Plaça, Dennyson Leandro M. Fonseca, Alexandre H. C. Marques, Igor Salerno Filgueiras, Victor Gabriel Bastos Chaves, Anny Silva Adri, Amanda Torrentes-Carvalho, Mario Hiroyuki Hirata, Paula Paccielli Freire, Rusan Catar, Gustavo Cabral-Miranda, Lena F. Schimke, Guido Moll, Otavio Cabral-Marques
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Fron. Immunol.
DOI: 10.3389/fimmu.2023.1243516

Surfing the Big Data Wave: Omics Data Challenges in Transplantation

Autori: Ba, Rokhaya; Geffard, Estelle; Douillard, Venceslas; Simon, Françoise; Mesnard, Laurent; Vince, Nicolas ; Gourraud, Pierre-Antoine; Limou, Sophie
Pubblicato in: Transplantation, 2021, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000003992

Multiple sclerosis clinical decision support system based on projection to reference datasets

Autori: Chadia Ed-driouch , Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David-Axel Laplaud, Franck Mars, Cedric Dumas, Gilles Edan & Pierre-Antoine Gourraud
Pubblicato in: Annals of Clinical and Translational Neurology, Numero Volume 9, Numero 12, 2022, Pagina/e 1863-1873, ISSN 2328-9503
Editore: -
DOI: 10.1002/acn3.51649

Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression

Autori: Danger R, Le Berre L, Cadoux M, Kerleau C, Papuchon E, Mai HL, Nguyen TV, Guérif P, Morelon E, Thaunat O, Legendre C, Anglicheau D, Lefaucheur C, Couzi L, Del Bello A, Kamar N, Le Quintrec M, Goutaudier V, Renaudin K, Giral M, Brouard S; DIVAT Consortium
Pubblicato in: Kidney International, Numero 2023 Jun;103(6):1167-1179, 2023, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.03.019

CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy

Autori: Marta Jarque, Edoardo Melilli, Elena Crespo, Anna Manonelles, Nuria Montero, Joan Torras, Josep M. Cruzado, Sergi Luque, Salvador Gil-Vernet, Josep M. Grinyó, Oriol Bestard
Pubblicato in: Transplantation, Numero 102, 2023, Pagina/e e472-e480, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000002421

Addressing the Challenges and Barriers to the Integration of Machine Learning into Clinical Practice: An Innovative Method to Hybrid Human–Machine Intelligence

Autori: Chadia Ed-driouch, Franck Mars, Pierre-Antoine Gourraud, Cédric Dumas
Pubblicato in: Sensors, Numero Volume 22, Numero 21, 2022, Pagina/e 8313, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22218313

A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

Autori: Daniel Yoo, Gillian Divard, Marc Raynaud, Aaron Cohen, Tom D. Mone, John Thomas Rosenthal, Andrew J. Bentall, Mark D. Stegall, Maarten Naesens, Huanxi Zhang, Changxi Wang, Juliette Gueguen, Nassim Kamar, Antoine Bouquegneau, Ibrahim Batal, Shana M. Coley, John S. Gill, Federico Oppenheimer, Erika De Sousa-Amorim, Dirk R. J. Kuypers, Antoine Durrbach, Daniel Seron, Marion Rabant, Jean-Paul Duong Va
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44595-z

Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)

Autori: François R Girardin, Anna Nicolet, Oriol Bestard, Carmen Lefaucheur, Klemens Budde, Fabian Halleck, Sophie Brouard, Magali Giral, Pierre-Antoine Gourraud, Béatrice Horcholle, Jean Villard, Joachim Marti, Alexandre Loupy
Pubblicato in: Frontiers in Pharmacology, Numero 2023 April 27, 2023, Pagina/e 14:1040584, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1040584

High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients

Autori: Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, José Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta, Irina B. Torres, Joana Sellarés, Manel Perelló, Hannah Kaminski, Lionel Couzi, Alexandre Loupy, Gaetano La Manna, Francesc Moreso, Paolo Crave
Pubblicato in: Kidney International, 2024, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.03.027

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling

Autori: Guido Moll, Christian Luecht, Michael Adu Gyamfi, Dennyson L. M. da Fonseca, Pinchao Wang, Hongfan Zhao, Zexian Gong, Lei Chen, Muhamad Imtiaz Ashraf, Harald Heidecke, Alexander Maximilian Hackel, Duska Dragun, Klemens Budde, Olaf Penack, Gabriela Riemekasten, Otávio Cabral-Marques, Janusz Witowski, Rusan Catar
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1289744

Distributing HLA database in histocompatibility: a shift in HLA data governance

Autori: Sirine Sayadi 1, 2 Venceslas Douillard 3, 4 Nicolas Vince 3, 4 Mario Südholt 1, 2 Pierre-Antoine Gourraud 4, 3
Pubblicato in: Exploration of Immunology , 2022, ISSN 2768-6655
Editore: Exploration of Immunology

Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study

Autori: Raynaud M, Al-Awadhi S, Juric I, Divard G, Lombardi Y, Basic-Jukic N, Aubert O, Dubourg L, Masson I, Mariat C, Prié D, Pernin V, Le Quintrec M, Larson TS, Stegall MD, Bikbov B, Ruggenenti P, Mesnard L, Ibrahim HN, Nielsen MB, Matas AJ, Nankivell BJ, Benjamens S, Pol RA, Bakker SJL, Jouven X, Legendre C, Kamar N, Smith BH, Wadei HM, Durrbach A, Vincenti F, Remuzzi G, Lefaucheur C, Bentall AJ, Loup
Pubblicato in: The BMJ, Numero 2023 May, 2023, Pagina/e 381:e073654, ISSN 0959-8138
Editore: BMJ
DOI: 10.1136/bmj-2022-073654

An automated histological classification system for precision diagnostics of kidney allografts

Autori: Yoo D, Goutaudier V, Divard G, Gueguen J, Astor BC, Aubert O, Raynaud M, Demir Z, Hogan J, Weng P, Smith J, Garro R, Warady BA, Zahr RS, Sablik M, Twombley K, Couzi L, Berney T, Boyer O, Duong-Van-Huyen JP, Giral M, Alsadi A, Gourraud PA, Morelon E, Le Quintrec M, Brouard S, Legendre C, Anglicheau D, Villard J, Zhong W, Kamar N, Bestard O, Djamali A, Budde K, Haas M, Lefaucheur C, Rabant M, Loupy
Pubblicato in: Nature medicine, Numero 2023 May, 2023, Pagina/e 29(5):1211-1220, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-023-02323-6

Comparison of artificial intelligence and human-based prediction and stratification of the risk of long-term kidney allograft failure.

Autori: Divard G, Raynaud M, Tatapudi VS, Abdalla B, Bailly E, Assayag M, Binois Y, Cohen R, Zhang H, Ulloa C, Linhares K, Tedesco HS, Legendre C, Jouven X, Montgomery RA, Lefaucheur C, Aubert O, Loupy A
Pubblicato in: Communications medicine, Numero 2022 Nov, 2022, Pagina/e 2(1):150, ISSN 2730-664X
Editore: PubMed Central
DOI: 10.1038/s43856-022-00201-9

Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

Autori: Valentin Goutaudier, Richard Danger, Rusan Ali Catar, Maud Racapé, Aurélie Philippe, Michelle Elias, Marc Raynaud, Olivier Aubert, Didier Bouton, François Girardin, Éric Vicaut, Sarhan Yaiche, Jacques Demotes, Harald Heidecke, Jean-Luc Taupin, Christine Randoux-Lebrun, Mohamad Zaidan, Emmanuelle Papuchon, Hoa Le Mai, Thi-Van-Ha Nguyen, Francesc Moreso, Thierry Berney, Jean Villard, Christophe
Pubblicato in: Kidney International, 2024, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.07.027

Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients

Autori: Gillian Divard, Olivier Aubert, Charlotte Debiais-Deschamp, Marc Raynaud, Valentin Goutaudier, Marta Sablik, Caroline Sayeg, Christophe Legendre, Julie Obert, Dany Anglicheau, Carmen Lefaucheur, Alexandre Loupy
Pubblicato in: Clinical Journal of the American Society of Nephrology, 2024, ISSN 1555-9041
Editore: American Society of Nephrology
DOI: 10.2215/cjn.0000000000000411

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

Autori: Thayna Silva-Sousa, Júlia Nakanishi Usuda, Nada Al-Arawe, Francisca Frias, Irene Hinterseher, Rusan Catar, Christian Luecht, Katarina Riesner, Alexander Hackel, Lena F Schimke, Haroldo Dutra Dias, Igor Salerno Filgueiras, Helder I Nakaya, Niels Olsen Saraiva Camara, Stefan Fischer, Gabriela Riemekasten, Olle Ringdén, Olaf Penack, Tobias Winkler, Georg Duda, Dennyson Leandro M Fonseca, Otávio Ca
Pubblicato in: Stem Cells, 2024, ISSN 1066-5099
Editore: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxae054

The Pseudokinase TRIB1 in Immune Cells and Associated Disorders

Autori: Richard Danger, Yodit Feseha and Sophie Brouard
Pubblicato in: Cancers, 2022, Pagina/e 14(4), ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14041011

Pretransplant Donor-specific IFNγ ELISPOT as a Predictor of Graft Rejection

Autori: Nuria Montero, Samira Farouk, Ilaria Gandolfini, Elena Crespo, Marta Jarque, Maria Meneghini, Alba Torija, Umberto Maggiore, Paolo Cravedi, Oriol Bestard
Pubblicato in: Transplantation Direct, Numero 5/5, 2019, Pagina/e e451, ISSN 2373-8731
Editore: Wolters Kluwer Health, Inc
DOI: 10.1097/txd.0000000000000886

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation

Autori: François Brinas, Richard Danger and Sophie Brouard
Pubblicato in: Cells, 2021, Pagina/e 10(6), ISSN 2073-4409
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10061367

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

Autori: Esteban Cortes Garcia, Alessia Giarraputo, Maud Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, Marc Raynaud, Clément Couderau, Fariza Mezine, Jessie Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, Fabian Halleck, Magali Giral, Sophie Brouard, Richard Danger, Pierre-Antoine Gourraud, Marion Rabant, Lionel Couzi, Moglie Le Quintrec, Nassim Kamar, Emmanu
Pubblicato in: Transplant International, Numero 37, 2024, ISSN 1432-2277
Editore: Wiley
DOI: 10.3389/ti.2024.13043

Editorial: Emerging talents in alloimmunity and transplantation: 2022

Autori: Guido Moll, Wai H. Lim, Olaf Penack
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Front. Immunol.
DOI: 10.3389/fimmu.2024.1393026

An exome-wide study of renal operational tolerance

Autori: Massart A*, Danger R*, Olsen C*, Emond M J, Viklicky O, Jacquemin V, Soblet J, Croes D, Perazzolo C, Hruba P, Daneels D, Caljon B, Sever M S, Pascual J, Pirson I, Ghisdal L, Smits G, Giral M, Abramowicz D, Abramowicz M and Brouard S
Pubblicato in: Frontiers in Medicine, Numero 17 May 2023 Sec. Nephrology Volume 9 - 2022, 2023, ISSN 2296-858X
Editore: -
DOI: 10.3389/fmed.2022.976248

FaDA: A web application for regular laboratory data analyses

Autori: Danger R, Moiteaux Q, Feseha Y, Geffard E, Ramstein G, Brouard S
Pubblicato in: PLoS One, 2021, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0261083

Secure distribution of Factor Analysis of Mixed Data (FAMD) and its application to personalized medicine of transplanted patients

Autori: S Sayadi, E Geffard, M Südholt, N Vince, PA Gourraud
Pubblicato in: Springer nature, 2021, ISSN 2509-4807
Editore: Springer
DOI: 10.1007/978-3-030-75100-5_44

Structural insights into the catalytic mechanism of granzyme B upon substrate and inhibitor binding

Autori: Tripathi N, Danger R, Chesneau M, Brouard S, Laurent AD
Pubblicato in: Journal of Molecular Graphics and Modelling, Numero 2022 Mar 22;114:108167, 2022, ISSN 1873-4243
Editore: ELSEVIER
DOI: 10.1016/j.jmgm.2022.108167

Prognostic Biomarkers in Kidney Transplantation: A Systematic Review and Critical Appraisal

Autori: Marc Raynaud, Solaf Al-Awadhi, Kevin Louis, Huanxi Zhang, Xiaojun Su, Valentin Goutaudier, Jiali Wang, Zeynep Demir, Yongcheng Wei, Agathe Truchot, Antoine Bouquegneau, Arnaud Del Bello, Élodie Bailly, Yannis Lombardi, Mehdi Maanaoui, Alessia Giarraputo, Sofia Naser, Gillian Divard, Olivier Aubert, Mohammad Hassan Murad, Changxi Wang, Longshan Liu, Oriol Bestard, Maarten Naesens, John J. Friedewa
Pubblicato in: Journal of the American Society of Nephrology, Numero 35, 2024, Pagina/e 177-188, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.0000000000000260

Blood Gene Signature as a Biomarker for Subclinical Kidney Allograft Rejection: Where Are We?

Autori: Christophe Masset, Richard Danger, Nicolas Degauque, Jacques Dantal, Magali Giral, Sophie Brouard
Pubblicato in: Transplantation, 2024, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000005105

Editorial: Pharmacoeconomics in the era of health technology assessment and outcomes research to prioritize resource use, innovation and investmentwww.frontiersin.org

Autori: François R. Girardin1, Karen Cohen, Matthias Schwenkglenks, Isabelle Durand-Zaleski
Pubblicato in: Frontiers in Pharmacology, Numero 2023 May 16, 2023, Pagina/e 14:1210002, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1210002

Relevance of the Banff Human Organ Transplant Consensus Gene Panel for Detecting Antibody and T-Cell–Mediated Rejection of Kidney Allografts

Autori: Alessia Giarraputo, Valentin Goutaudier, Blaise Robin, Annalisa Angelini, Marta Sablik, Olivier Aubert, Ivy A. Rosales, Rex N. Smith, Candice Roufosse, Benjamin Adam, Mark Haas, Robert B. Colvin, Carmen Lefaucheur, Michael Mengel, Dina Zielinski, Alexandre Loupy
Pubblicato in: Kidney International Reports, Numero 9, 2024, Pagina/e 2290-2294, ISSN 2468-0249
Editore: Elsevier Inc.
DOI: 10.1016/j.ekir.2024.04.054

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